Pralidoxima
| Pralidoxima | |
|---|---|
 | |
| Formula kimikoa | C7H9N2O⁺ |
| SMILES kanonikoa | [NH+=O&zoom=2.0&annotate=none 2D eredua] |
| SMILES isomerikoa | C[N+]1=CC=CC=C1/C=N/O |
| MolView | [NH+=O 3D eredua] |
| Mota | organic cation (en)  eta monocation (en) |
| Masa molekularra | 137,071488 Da |
| Erabilera | |
| Elkarrekintza | Azetilkolinesterasa |
| Hartzeko bidea | intravenous infusion and defusion (en) , intramuscular injection (en) eta larruazalpeko |
| Rola | cholinesterase reactivator (en) eta Antidoto |
| Identifikatzaileak | |
| InChlKey | JBKPUQTUERUYQE-UHFFFAOYSA-O |
| CAS zenbakia | 6735-59-7 |
| ChemSpider | 5193737 |
| PubChem | 135398747, 4884 eta 135484646 |
| Reaxys | 1526531 |
| Gmelin | 8354 |
| ChEMBL | CHEMBL1420 |
| EC zenbakia | 229-787-0 |
| ECHA | 100.027.080 |
| MeSH | C028797 |
| RxNorm | 1546365 eta 34345 |
| Human Metabolome Database | HMDB0014871 |
| UNII | P7MU9UTP52 eta YV274KB8PY |
| NDF-RT | N0000147985 |
| KEGG | C07400 |
Pradiloxima konposatu organiko aromatiko heteroziklikoa da, C7H9N2O+ formula duena oximen klasekoa. Kloruro edo ioduro gisa egoten da. Solido zuria da[1].
Sintesia
Pralidoxima sintetizatzeko piridin-2-karboxaldeidoa hidroxilaminarekin tratatuz prestatzen da. Lortutako piridin-2-aldoxima metil ioduroarekin alkilatzen da, pralidoxima ioduro gisa emanez[2].
Erabilera
Organofosfatoek eragindako intoxikazioak tratatzeko usatzen da atropinarekin eta diazepamarekin batera emanda. Nerbio-agenteen bidezko pozoitzeak ere tratatzeko balia daiteke[3].
Sarina bezalako organofosfatoak azetilkolinesterasa entzimaren gune aktiboaren hidroxiloari lotzen zaizkio, eta, horrela, entzimaren jarduera blokeatzen da. Pralidoximak blokeo hori gertatzea eragozten du.
Erreferentziak
- ↑ (Ingelesez) PubChem. «Pralidoxime» pubchem.ncbi.nlm.nih.gov (kontsulta data: 2025-10-26).
- ↑ Alkyl pyridinium salt, 2-carboxaldehyde oximes and process of preparation. .
- ↑ (Ingelesez) Jokanovic, Milan; Prostran, Milica. «Pyridinium Oximes as Cholinesterase Reactivators. Structure-Activity Relationship and Efficacy in the Treatment of Poisoning with Organophosphorus Compounds» Current Medicinal Chemistry 16 (17): 2177–2188. doi:. (kontsulta data: 2025-10-26).
| Autoritate kontrola |
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Datuak: Q2735334
Multimedia: Pralidoxime / Q2735334
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