Pankreatitis akutu

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Pankreatitis akutu
Deskribapena
Motapankreatitisa
eritasuna
Espezialitateadigestio aparatuaren medikuntza
Identifikatzaileak
GNS-10-MKK85 eta K85.9
GNS-9-MK577.0
DiseasesDB9539
MedlinePlus000287
eMedicine000287
Disease Ontology IDDOID:2913

Pankreatitis akutua[1] pankreako hantura-prozesu akutua da, entzima pankreatikoen aktibazio desegokiaren ondorioz sortua, lesio tisularrarekin eta inflamatorio lokalarekin, eta urruneko beste ehun edo sistema organiko batzuen hantura eta konpromiso aldakorra.

Fisiopatologia

Pankreatitis akutuan pankrearen hantura gertatzen da, pankreako entzimen intragdular aktibazioaren sekundarioa. Mikrokirkulazioan alterazioak gertatzen dira: basokonstrikzioa, estasi kapilarra, oxigeno-asetasuna gutxitzea eta iskemia progresiboa. Anomalia horiek iragazkortasun baskularra areagotzen dute eta guruinaren edematizazioa eragiten dute, eta, gainera, peritoneoan proteina ugari dituen fluido intrabaskularraren estrabasazioa eragin dezake. Pankreatitis akutuan, hanturazko erantzun sistemikoaren sindromea (SRIS) ohikoa da, eta, ziurrenik, pankreako entzimek eta entzima zitokinek eragiten dute; entzima horiek aktibatuta daude, eta handitutako pankreatik zirkulaziora askatuta daude. Pankrea-kalte larria duten paziente batzuek konplikazio sistemiko larriak izaten dituzte, hala nola sukarra, arnas distress akutuaren sindromea (SDRA), pleura-isuriak, giltzurrun-gutxiegitasuna, shocka, miokardio-depresioa eta konplikazio metabolikoak (hipokaltzemia, hiperlipidemia, hipergluzemia, hipogluzemia). Pankreatitis akutu batean, hesteetako iskemiaren ondorioz ziurrenik, hesteetako hesia hautsi eta hesteetatik bakterioak translokatzea ahalbidetu daiteke, eta horrek infekzio lokala eta sistemikoa eragin dezake.

Erreferentziak

  1. ↑ Euskalterm: [Hiztegi terminologikoa] [2005]

Kanpo estekak


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