Class of enzymes
Unspecific peroxygenase (EC 1.11.2.1 , aromatic peroxygenase , mushroom peroxygenase , haloperoxidase-peroxygenase , Agrocybe aegerita peroxidase ) is an enzyme with systematic name substrate:hydrogen peroxide oxidoreductase (RH-hydroxylating or -epoxidising) .[ 1] [ 2] [ 3] [ 4] [ 5] [ 6] [ 7] [ 8] [ 9] catalyses the following chemical reaction
RH + H2 O2
⇌
{\displaystyle \rightleftharpoons }
2 O Unspecific peroxygenase is a heme -thiolate protein comparable to Cytochrome P450 in the ability to catalyze a variety of P450 reactions (hence "unspecific"), but forms a unique, solely fungal, protein family of extracellular enzymes.
References
^ Ullrich R, Nüske J, Scheibner K, Spantzel J, Hofrichter M (August 2004). "Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes" . Applied and Environmental Microbiology . 70 (8): 4575– 81. Bibcode :2004ApEnM..70.4575U . doi :10.1128/AEM.70.8.4575-4581.2004 . PMC 492325 PMID 15294788 . ^ Ullrich R, Hofrichter M (November 2005). "The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene" . FEBS Letters . 579 (27): 6247– 50. Bibcode :2005FEBSL.579.6247U . doi :10.1016/j.febslet.2005.10.014 PMID 16253244 . ^ Anh DH, Ullrich R, Benndorf D, Svatos A, Muck A, Hofrichter M (September 2007). "The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation" . Applied and Environmental Microbiology . 73 (17): 5477– 85. Bibcode :2007ApEnM..73.5477A . doi :10.1128/AEM.00026-07 . PMC 2042081 PMID 17601809 . ^ Ullrich R, Dolge C, Kluge M, Hofrichter M (December 2008). "Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita" . FEBS Letters . 582 (29): 4100– 6. Bibcode :2008FEBSL.582.4100U . doi :10.1016/j.febslet.2008.11.006 PMID 19022254 . S2CID 28889201 . ^ Aranda E, Kinne M, Kluge M, Ullrich R, Hofrichter M (April 2009). "Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases". Applied Microbiology and Biotechnology . 82 (6): 1057– 66. doi :10.1007/s00253-008-1778-6 . PMID 19039585 . S2CID 28195958 . ^ Kinne M, Poraj-Kobielska M, Aranda E, Ullrich R, Hammel KE, Scheibner K, Hofrichter M (June 2009). "Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with a fungal peroxygenase" Bioorganic & Medicinal Chemistry Letters . 19 (11): 3085– 7. doi :10.1016/j.bmcl.2009.04.015 . PMID 19394224 . [dead link ^ Kluge M, Ullrich R, Dolge C, Scheibner K, Hofrichter M (January 2009). "Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation" . Applied Microbiology and Biotechnology . 81 (6): 1071– 6. doi :10.1007/s00253-008-1704-y . PMID 18815784 . S2CID 28759836 . ^ Kinne M, Poraj-Kobielska M, Ralph SA, Ullrich R, Hofrichter M, Hammel KE (October 2009). "Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase" . The Journal of Biological Chemistry . 284 (43): 29343– 9. doi :10.1074/jbc.M109.040857 PMC 2785565 PMID 19713216 . ^ Pecyna MJ, Ullrich R, Bittner B, Clemens A, Scheibner K, Schubert R, Hofrichter M (October 2009). "Molecular characterization of aromatic peroxygenase from Agrocybe aegerita" . Applied Microbiology and Biotechnology . 84 (5): 885– 97. doi :10.1007/s00253-009-2000-1 . PMID 19434406 . S2CID 13141260 .
External links
Activity Regulation Classification Kinetics Types
