UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase

UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase
Identifiers
EC no.2.4.1.285
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase (EC 2.4.1.285, neoK (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:ribostamycin N-acetylglucosaminyltransferase.[1] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-alpha-D-glucosamine + ribostamycin UDP + 2'''-acetyl-6'''-hydroxyneomycin C

Involved in biosynthesis of the aminoglycoside antibiotic neomycin.

References

  1. ^ Yokoyama K, Yamamoto Y, Kudo F, Eguchi T (April 2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9 (6): 865–9. doi:10.1002/cbic.200700717. PMID 18311744.