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UGT1A9
Identifiers
Aliases	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I, UGT1A9S, UDP glucuronosyltransferase family 1 member A9
External IDs	OMIM: 606434; MGI: 3580642; HomoloGene: 133281; GeneCards: UGT1A9; OMA:UGT1A9 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,726 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; renal cortex; ; human kidney; ; mucosa of transverse colon; ; rectum; ; urinary bladder; ; olfactory zone of nasal mucosa; ; duodenum; ; body of stomach; ; islet of Langerhans;
	Top expressed in
	renal cortex; ; nephron; ; proximal tubule; ; renal medulla; ; human kidney; ; hair; ; renal pelvis; ; metanephros; ; lateral recess; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; enzyme inhibitor activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; glucuronosyltransferase activity; protein heterodimerization activity; enzyme binding; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	retinoic acid metabolic process; negative regulation of cellular glucuronidation; cellular glucuronidation; flavonoid glucuronidation; xenobiotic glucuronidation; flavone metabolic process; xenobiotic metabolic process; negative regulation of glucuronosyltransferase activity; negative regulation of fatty acid metabolic process; regulation of lipid metabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	54600
	394430
	ENSG00000241119
	ENSMUSG00000090165
	O60656
	n/a
	NM_021027
	NM_201641
	NP_066307
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.^[5]^[6]^[7]^[8]

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".

Inhibitors

BI-3231, an inhibitor of HSD17B13, was also found to inhibit UGT1A9.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000241119 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090165 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, Burchell B (September 1991). "Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family". The Biochemical Journal. 278 (Pt 2): 465–469. doi:10.1042/bj2780465. PMC 1151367. PMID 1910331.
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, et al. (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–269. doi:10.1097/00008571-199708000-00001. PMID 9295054.
^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, et al. (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". The Journal of Biological Chemistry. 267 (5): 3257–3261. doi:10.1016/S0021-9258(19)50724-4. PMID 1339448.
^ ^a ^b "Entrez Gene: UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9".
^ Thamm S, Willwacher MK, Aspnes GE, Bretschneider T, Brown NF, Buschbom-Helmke S, et al. (February 2023). "Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science". Journal of Medicinal Chemistry. 66 (4): 2832–2850. doi:10.1021/acs.jmedchem.2c01884. PMC 9969402. PMID 36727857.

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