As a freshman in 2019, Hopper notched two tackles with 0.5 tackles going for loss.[5] As a sophomore, he recorded 13 tackles with one going for a loss, and half a sack.[6] In the Gators season finale of the 2021 season, Hopper had nine tackles and a forced fumble as he helped the Gators beat Florida State and become bowl eligible.[7] He finished the season with 62 tackles with eight going for a loss, 2.5 sacks, two pass deflections and a forced fumble.[8] After the conclusion of the 2021 season, Hopper entered the transfer portal.[9][10]
Missouri
Hopper transferred to Missouri to continue his college career.[11][12] Hopper started the 2022 season off to a hot start, as in week one he racked up six tackles, a sack, and his first career interception, as he helped the Tigers beat Louisiana Tech.[13] In week five, Hopper notched seven tackles and a forced fumble in a 26–22 loss to #1 Georgia.[14] Hopper finished the 2022 season with 77 tackles with 13.5 being for a loss, 2.5 sacks, four pass deflections, an interception, and a forced fumble.[15] For his performance, Hopper was named second team All-SEC by the Associated Press.[16] Hopper was named preseason second-team all-SEC ahead of the 2023 season.[17] Hopper was also named a preseason third-team All-American by Athlon Sports.[18] Hopper was also named to the Butkus Award watch list, which is awarded to the nation's best linebacker.[19]
The Green Bay Packers selected Hopper with 91st overall pick in the 2024 NFL draft, after having previously acquired it in a trade with the Buffalo Bills.[22] On May 14, he signed his contract with the Packers.[23]