In enzymology, a N-acylmannosamine 1-dehydrogenase (EC 1.1.1.233) is an enzyme that catalyzes the chemical reaction

N-acyl-D-mannosamine + NAD⁺ ${\displaystyle \rightleftharpoons }$ N-acyl-D-mannosaminolactone + NADH + H⁺

Thus, the two substrates of this enzyme are N-acyl-D-mannosamine and NAD⁺, whereas its 3 products are N-acyl-D-mannosaminolactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is N-acyl-D-mannosamine:NAD⁺ 1-oxidoreductase. Other names in common use include N-acylmannosamine dehydrogenase, N-acetyl-D-mannosamine dehydrogenase, N-acyl-D-mannosamine dehydrogenase, and N-acylmannosamine dehydrogenase.

• Horiuchi T, Kurokawa T (September 1988). "Purification and properties of N-acyl-D-mannosamine dehydrogenase from Flavobacterium sp. 141-8". J. Biochem. 104 (3). Tokyo: 466–71. PMID 3240988.