Class of enzymes
In enzymology , a choline dehydrogenase (EC 1.1.99.1 ) is an enzyme that catalyzes the chemical reaction
choline + acceptor
⇌ ⇌ -->
{\displaystyle \rightleftharpoons }
betaine aldehyde + reduced acceptor
Thus, the two substrates of this enzyme are choline and acceptor , whereas its two products are betaine aldehyde and reduced acceptor .
This enzyme belongs to the family of oxidoreductases , specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is choline:acceptor 1-oxidoreductase . Other names in common use include choline oxidase , choline-cytochrome c reductase , choline:(acceptor) oxidoreductase , and choline:(acceptor) 1-oxidoreductase . This enzyme participates in glycine, serine and threonine metabolism . It employs one cofactor , PQQ .
References
Minoru Ameyama; Emiko Shinagawa; Kazunobu Matsushita; Koichi Takimoto; Koji Nakashima; Osao Adachi (1985). "Mammalian choline dehydrogenase is a quinoprotein" . Agric. Biol. Chem . 49 (12): 3623–3626. doi :10.1271/bbb1961.49.3623 .
Ebisuzaki K, Williams JN (1955). "Preparation and partial purification of soluble choline dehydrogenase from liver mitochondria" . Biochem. J . 60 (4): 644–6. doi :10.1042/bj0600644 . PMC 1216163 . PMID 13249959 .
Gadda G, McAllister-Wilkins EE (2003). "Cloning, Expression, and Purification of Choline Dehydrogenase from the Moderate Halophile Halomonas elongata" . Appl. Environ. Microbiol . 69 (4): 2126–32. doi :10.1128/AEM.69.4.2126-2132.2003 . PMC 154813 . PMID 12676692 .
Takabe T; Tanaka, Y; Aoki, K; Hibino, T; Jikuya, H; Takano, J; Takabe, T; Takabe, T (2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica" . J. Biol. Chem . 278 (7): 4932–42. doi :10.1074/jbc.M210970200 . PMID 12466265 .
Activity Regulation Classification Kinetics Types