Mir-17 microRNA precursor family

mir-17 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-17
Identifiers
Symbolmir-17
RfamRF00051
miRBaseMI0000071
miRBase familyMIPF0000001
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families.[1] These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA.[2][3]

The paralogous miRNA gene clusters that give rise to miR-17 family microRNAs (miR-17~92, miR-106a~363, and miR-106b~25) have been implicated in a wide variety of malignancies and are sometimes referred to as oncomirs.[4] The oncogenic potential of these non-protein encoding genes was first identified in mouse viral tumorigenesis screens.[5][6][7] In humans, the activating mutations of miR-17~92 have been identified in non-Hodgkin's lymphoma, whereas the miRNA constituents of the clusters are overexpressed in a multiple cancer types.[8][9][10] High level expression of miR-17 family members induces cell proliferation, whereas deletion of the miR-17~92 cluster, in mice, is lethal and causes lung and lymphoid cell developmental defects.[11] In addition, in the nasopharyngeal carcinoma cell line, miR-20a and miR-20b has been shown to target the 3’ UTR of vascular endothelial growth factor (VEGF) and repress the expression of VEGF, which is an important angiogenic factor.[12][13] miR-20a detection in human faeces could be a non-invasive screening marker for colorectal cancer.[14]

References

  1. ^ Tanzer A, Stadler PF (2004). "Molecular evolution of a microRNA cluster". J Mol Biol. 339 (2): 327–35. CiteSeerX 10.1.1.194.1598. doi:10.1016/j.jmb.2004.03.065. PMID 15136036.
  2. ^ Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science. 294 (5543): 853–858. Bibcode:2001Sci...294..853L. doi:10.1126/science.1064921. hdl:11858/00-001M-0000-0012-F65F-2. PMID 11679670. S2CID 18101169.
  3. ^ Ambros V (2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
  4. ^ Hammond, SM. (Nov 2006). "RNAi, microRNAs, and human disease". Cancer Chemother Pharmacol. 58 (Suppl 1): s63–8. doi:10.1007/s00280-006-0318-2. PMID 17093929. S2CID 682108.
  5. ^ Hwang HC, Martins CP, Bronkhorst Y, Randel E, Berns A, Fero ML, Clurman BE (2002). "Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis". Proc Natl Acad Sci U S A. 99 (17): 11293–8. doi:10.1073/pnas.162356099. PMC 123250. PMID 12151601.
  6. ^ Wang CL, Wang BB, Bartha G, Li L, Channa N, Klinger M, Killeen N, Wabl M (2006). "Activation of an oncogenic microRNA cistron by provirus integration". Proc Natl Acad Sci U S A. 103 (49): 18680–4. Bibcode:2006PNAS..10318680W. doi:10.1073/pnas.0609030103. PMC 1693722. PMID 17121985.
  7. ^ Landais S, Landry S, Legault P, Rassart E (2007). "Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia". Cancer Res. 67 (12): 5699–707. doi:10.1158/0008-5472.CAN-06-4478. PMID 17575136.
  8. ^ Ota A, Tagawa H, Karnan S, Tsuzuki S, Karpas A, Kira S, Yoshida Y, Seto M (2004). "Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma". Cancer Res. 64 (9): 3087–95. doi:10.1158/0008-5472.CAN-03-3773. PMID 15126345.
  9. ^ Rinaldi A, Poretti G, Kwee I, Zucca E, Catapano CV, Tibiletti MG, Bertoni F (2007). "Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphoma". Leuk Lymphoma. 48 (2): 410–2. doi:10.1080/10428190601059738. PMID 17325905. S2CID 2941415.
  10. ^ Mendell JT (2008). "miRiad roles for the miR-17-92 cluster in development and disease". Cell. 133 (2): 217–22. doi:10.1016/j.cell.2008.04.001. PMC 2732113. PMID 18423194.
  11. ^ Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, et al. (2008). "Targeted deletion reveals essential and overlapping functions of the miR-17~92 family of miRNA clusters". Cell. 132 (5): 875–86. doi:10.1016/j.cell.2008.02.019. PMC 2323338. PMID 18329372.
  12. ^ Hua Z, Lv Q, Ye W, Wong CK, Cai G, Gu D, Ji Y, Zhao C, Wang J, Yang BB, Zhang Y (Dec 27, 2006). "MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia". PLOS ONE. 1 (1): e116. Bibcode:2006PLoSO...1..116H. doi:10.1371/journal.pone.0000116. PMC 1762435. PMID 17205120.
  13. ^ Ye W, Lv Q, Wong CK, Hu S, Fu C, Hua Z, Cai G, Li G, Yang BB, Zhang Y (Mar 5, 2008). "The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation". PLOS ONE. 3 (3): e1719. Bibcode:2008PLoSO...3.1719Y. doi:10.1371/journal.pone.0001719. PMC 2248708. PMID 18320040.
  14. ^ Yau, TO; Wu, CW; Tang, CM; Chen, Y; Fang, J; Dong, Y; Liang, Q; Ng, SS; Chan, FK; Sung, JJ; Yu, J (12 January 2016). "MicroRNA-20a in human faeces as a non-invasive biomarker for colorectal cancer". Oncotarget. 7 (2): 1559–68. doi:10.18632/oncotarget.6403. PMC 4811480. PMID 26621842.

Further reading


  1. ^ Dews M, Fox JL, Hultine S, Sundaram P, Wang W, Liu YY, Furth E, Enders GH, El-Deiry W, Schelter JM, Cleary MA, Thomas-Tikhonenko A (2010). "The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors". Cancer Res. 70 (20): 8233–46. doi:10.1158/0008-5472.CAN-10-2412. PMC 3007123. PMID 20940405.
  2. ^ Xiang J, Wu J (2010). "Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis". Curr Genomics. 11 (2): 129–35. doi:10.2174/138920210790886853. PMC 2874222. PMID 20885820.
  3. ^ Wang Z, Liu M, Zhu H, Zhang W, He S, Hu C, Quan L, Bai J, Xu N (2010). "Suppression of p21 by c-Myc through members of miR-17 family at the post-transcriptional level". Int J Oncol. 37 (5): 1315–21. doi:10.3892/ijo_00000783. PMID 20878079.
  4. ^ Hong L, Lai M, Chen M, Xie C, Liao R, Kang YJ, Xiao C, Hu WY, Han J, Sun P (2010). "The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence". Cancer Res. 70 (21): 8547–57. doi:10.1158/0008-5472.CAN-10-1938. PMC 2970743. PMID 20851997.
  5. ^ Osada H, Takahashi T (2010). "Review Article: let-7 and miR-17-92: Small-sized major players in lung cancer development". Cancer Sci. 102 (1): 9–17. doi:10.1111/j.1349-7006.2010.01707.x. PMID 20735434. S2CID 21262482.
  6. ^ Cox MB, Cairns MJ, Gandhi KS, Carroll AP, Moscovis S, Stewart GJ, Broadley S, Scott RJ, Booth DR, Lechner-Scott J, ANZgene Multiple Sclerosis Genetics Consortium (2010). Jacobson S (ed.). "MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood". PLOS ONE. 5 (8): e12132. Bibcode:2010PLoSO...512132C. doi:10.1371/journal.pone.0012132. PMC 2920328. PMID 20711463.
  7. ^ Yu J, Ohuchida K, Mizumoto K, Fujita H, Nakata K, Tanaka M (2010). "MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis and involved in cancer cell proliferation and invasion". Cancer Biol Ther. 10 (8): 748–757. doi:10.4161/cbt.10.8.13083. PMID 20703102. S2CID 12028238.
  8. ^ Zhuo de X, Niu XH, Chen YC, Xin DQ, Guo YL, Mao ZB (2010). "Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts". J Biol Chem. 285 (41): 31491–501. doi:10.1074/jbc.M109.068387. PMC 2951223. PMID 20656682.
  9. ^ Kuhnert F, Kuo CJ (2010). "miR-17-92 angiogenesis micromanagement". Blood. 115 (23): 4631–3. doi:10.1182/blood-2010-03-276428. PMID 20538815.
  10. ^ Li H, Bian C, Liao L, Li J, Zhao RC (2010). "miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1". Breast Cancer Res Treat. 126 (3): 565–575. doi:10.1007/s10549-010-0954-4. PMID 20505989. S2CID 24272629.
  11. ^ Budde H, Schmitt S, Fitzner D, Opitz L, Salinas-Riester G, Simons M (2010). "Control of oligodendroglial cell number by the miR-17-92 cluster". Development. 137 (13): 2127–32. doi:10.1242/dev.050633. PMID 20504959.
  12. ^ Grillari J, Hackl M, Grillari-Voglauer R (2010). "miR-17-92 cluster: ups and downs in cancer and aging". Biogerontology. 11 (4): 501–6. doi:10.1007/s10522-010-9272-9. PMC 2899009. PMID 20437201.
  13. ^ Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML (2010). "The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression". Cancer Res. 70 (9): 3833–42. doi:10.1158/0008-5472.CAN-09-3268. PMC 2862107. PMID 20406979.
  14. ^ Ernst A, Campos B, Meier J, Devens F, Liesenberg F, Wolter M, Reifenberger G, Herold-Mende C, Lichter P, Radlwimmer B (2010). "De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures". Oncogene. 29 (23): 3411–22. doi:10.1038/onc.2010.83. PMID 20305691.
  15. ^ He S, Yang S, Deng G, Liu M, Zhu H, Zhang W, Yan S, Quan L, Bai J, Xu N (2010). "Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor". Cell Mol Life Sci. 67 (12): 2069–76. doi:10.1007/s00018-010-0340-8. PMC 11115945. PMID 20300951. S2CID 31290845.
  16. ^ Olive V, Jiang I, He L (2010). "mir-17-92, a cluster of miRNAs in the midst of the cancer network". Int J Biochem Cell Biol. 42 (8): 1348–54. doi:10.1016/j.biocel.2010.03.004. PMC 3681296. PMID 20227518.
  17. ^ Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O (2010). "The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity". Development. 137 (7): 1107–16. doi:10.1242/dev.046045. PMC 2835326. PMID 20215348.
  18. ^ Yang F, Yin Y, Wang F, Wang Y, Zhang L, Tang Y, Sun S (2010). "miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway". Hepatology. 51 (5): 1614–23. doi:10.1002/hep.23566. PMID 20209605. S2CID 4579895.
  19. ^ Sasaki K, Kohanbash G, Hoji A, Ueda R, McDonald HA, Reinhart TA, Martinson J, Lotze MT, Marincola FM, Wang E, Fujita M, Okada H (2010). "miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy". J Transl Med. 8 (1): 17. doi:10.1186/1479-5876-8-17. PMC 2836279. PMID 20167088.
  20. ^ Lindberg RL, Hoffmann F, Mehling M, Kuhle J, Kappos L (2010). "Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients". Eur J Immunol. 40 (3): 888–98. doi:10.1002/eji.200940032. PMID 20148420. S2CID 205786377.
  21. ^ Mi S, Li Z, Chen P, He C, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J (2010). "Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia". Proc Natl Acad Sci U S A. 107 (8): 3710–5. Bibcode:2010PNAS..107.3710M. doi:10.1073/pnas.0914900107. PMC 2840429. PMID 20133587.
  22. ^ Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Mück C, Laschober GT, Lepperdinger G, Sampson N, Berger P, Herndler-Brandstetter D, Wieser M, Kühnel H, Strasser A, Rinnerthaler M, Breitenbach M, Mildner M, Eckhart L, Tschachler E, Trost A, Bauer JW, Papak C, Trajanoski Z, Scheideler M, Grillari-Voglauer R, Grubeck-Loebenstein B, Jansen-Dürr P, Grillari J (2010). "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging". Aging Cell. 9 (2): 291–6. doi:10.1111/j.1474-9726.2010.00549.x. PMC 2848978. PMID 20089119.
  23. ^ van Haaften G, Agami R (2010). "Tumorigenicity of the miR-17-92 cluster distilled". Genes Dev. 24 (1): 1–4. doi:10.1101/gad.1887110. PMC 2802185. PMID 20047995.
  24. ^ Chow TF, Mankaruos M, Scorilas A, Youssef Y, Girgis A, Mossad S, Metias S, Rofael Y, Honey RJ, Stewart R, Pace KT, Yousef GM (2010). "The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma". J Urol. 183 (2): 743–51. doi:10.1016/j.juro.2009.09.086. PMID 20022054.
  25. ^ Olive V, Bennett MJ, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li QJ, Lowe SW, Hannon GJ, He L (2009). "miR-19 is a key oncogenic component of mir-17-92". Genes Dev. 23 (24): 2839–49. doi:10.1101/gad.1861409. PMC 2800084. PMID 20008935.
  26. ^ Mu P, Han YC, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D'Andrea A, Sander C, Ventura A (2009). "Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas". Genes Dev. 23 (24): 2806–11. doi:10.1101/gad.1872909. PMC 2800095. PMID 20008931.
  27. ^ Guo L, Sun B, Sang F, Wang W, Lu Z (2009). Poon AF (ed.). "Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis". PLOS ONE. 4 (11): e7944. Bibcode:2009PLoSO...4.7944G. doi:10.1371/journal.pone.0007944. PMC 2775919. PMID 19956752.
  28. ^ ZHANG ZW, AN Y, TENG CB (2009). "[The roles of miR-17-92 cluster in mammal development and tumorigenesis]". Hereditas (Beijing). 31 (11): 1094–100. doi:10.3724/SP.J.1005.2009.01094. PMID 19933089. S2CID 37278212.
  29. ^ Sun H, Li QW, Lv XY, Ai JZ, Yang QT, Duan JJ, Bian GH, Xiao Y, Wang YD, Zhang Z, Liu YH, Tan RZ, Yang Y, Wei YQ, Zhou Q (2010). "MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation". Mol Biol Rep. 37 (6): 2951–8. doi:10.1007/s11033-009-9861-3. PMID 19821056. S2CID 21807969.
  30. ^ Yan HL, Xue G, Mei Q, Wang YZ, Ding FX, Liu MF, Lu MH, Tang Y, Yu HY, Sun SH (2009). "Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis". EMBO J. 28 (18): 2719–32. doi:10.1038/emboj.2009.214. PMC 2750010. PMID 19696742.
  31. ^ Diosdado B, van de Wiel MA, Terhaar Sive Droste JS, Mongera S, Postma C, Meijerink WJ, Carvalho B, Meijer GA (2009). "MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression". Br J Cancer. 101 (4): 707–14. doi:10.1038/sj.bjc.6605037. PMC 2736819. PMID 19672269.
  32. ^ Beveridge NJ, Tooney PA, Carroll AP, Tran N, Cairns MJ (2009). "Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation". Cell Signal. 21 (12): 1837–45. doi:10.1016/j.cellsig.2009.07.019. PMID 19666108.
  33. ^ Shan SW, Lee DY, Deng Z, Shatseva T, Jeyapalan Z, Du WW, Zhang Y, Xuan JW, Yee SP, Siragam V, Yang BB (2009). "MicroRNA MiR-17 retards tissue growth and represses fibronectin expression". Nat Cell Biol. 11 (8): 1031–8. doi:10.1038/ncb1917. PMID 19633662. S2CID 5180603.
  34. ^ Ebi H, Sato T, Sugito N, Hosono Y, Yatabe Y, Matsuyama Y, Yamaguchi T, Osada H, Suzuki M, Takahashi T (2009). "Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancers". Oncogene. 28 (38): 3371–9. doi:10.1038/onc.2009.201. PMID 19597473. S2CID 1939787.
  35. ^ Carraro G, El-Hashash A, Guidolin D, Tiozzo C, Turcatel G, Young BM, De Langhe SP, Bellusci S, Shi W, Parnigotto PP, Warburton D (2009). "miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution". Dev Biol. 333 (2): 238–50. doi:10.1016/j.ydbio.2009.06.020. PMC 2735610. PMID 19559694.
  36. ^ Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD (2009). "The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors". Cancer Res. 69 (8): 3249–55. doi:10.1158/0008-5472.CAN-08-4710. PMC 2836891. PMID 19351822.
  37. ^ Robertus JL, Harms G, Blokzijl T, Booman M, de Jong D, van Imhoff G, Rosati S, Schuuring E, Kluin P, van den Berg A (2009). "Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma". Mod Pathol. 22 (4): 547–55. doi:10.1038/modpathol.2009.10. PMID 19287466.
  38. ^ Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, Roussel MF (2009). "The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma". Proc Natl Acad Sci U S A. 106 (8): 2812–7. Bibcode:2009PNAS..106.2812U. doi:10.1073/pnas.0809579106. PMC 2636735. PMID 19196975.
  39. ^ Nagel S, Venturini L, Przybylski GK, Grabarczyk P, Schmidt CA, Meyer C, Drexler HG, Macleod RA, Scherr M (2009). "Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia". Leuk Lymphoma. 50 (1): 101–8. doi:10.1080/10428190802626632. PMID 19148830. S2CID 40256612.
  40. ^ Foshay KM, Gallicano GI (2009). "miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation". Dev Biol. 326 (2): 431–43. doi:10.1016/j.ydbio.2008.11.016. PMID 19073166.
  41. ^ Aguda BD, Kim Y, Piper-Hunter MG, Friedman A, Marsh CB (2008). "MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc". Proc Natl Acad Sci U S A. 105 (50): 19678–83. Bibcode:2008PNAS..10519678A. doi:10.1073/pnas.0811166106. PMC 2598727. PMID 19066217.
  42. ^ Petrocca F, Vecchione A, Croce CM (2008). "Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling". Cancer Res. 68 (20): 8191–4. doi:10.1158/0008-5472.CAN-08-1768. PMID 18922889.
  43. ^ Pickering MT, Stadler BM, Kowalik TF (2009). "miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression". Oncogene. 28 (1): 140–5. doi:10.1038/onc.2008.372. PMC 2768269. PMID 18836483.
  44. ^ Cloonan N, Brown MK, Steptoe AL, Wani S, Chan WL, Forrest AR, Kolle G, Gabrielli B, Grimmond SM (2008). "The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition". Genome Biol. 9 (8): R127. doi:10.1186/gb-2008-9-8-r127. PMC 2575517. PMID 18700987.
  45. ^ Connolly E, Melegari M, Landgraf P, Tchaikovskaya T, Tennant BC, Slagle BL, Rogler LE, Zavolan M, Tuschl T, Rogler CE (2008). "Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype". Am J Pathol. 173 (3): 856–64. doi:10.2353/ajpath.2008.080096. PMC 2527078. PMID 18688024.
  46. ^ Xu X, Hong Y, Kong C, Xu L, Tan J, Liang Q, Huang B, Lu J (2008). "Protein tyrosine phosphatase receptor-type O (PTPRO) is co-regulated by E2F1 and miR-17-92". FEBS Lett. 582 (19): 2850–6. doi:10.1016/j.febslet.2008.07.017. PMID 18644370. S2CID 5288582.
  47. ^ Taguchi A, Yanagisawa K, Tanaka M, Cao K, Matsuyama Y, Goto H, Takahashi T (2008). "Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster". Cancer Res. 68 (14): 5540–5. doi:10.1158/0008-5472.CAN-07-6460. PMID 18632605.
  48. ^ Takakura S, Mitsutake N, Nakashima M, Namba H, Saenko VA, Rogounovitch TI, Nakazawa Y, Hayashi T, Ohtsuru A, Yamashita S (2008). "Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells" (PDF). Cancer Sci. 99 (6): 1147–54. doi:10.1111/j.1349-7006.2008.00800.x. hdl:10069/22014. PMID 18429962.
  49. ^ Mendell JT (2008). "miRiad roles for the miR-17-92 cluster in development and disease". Cell. 133 (2): 217–22. doi:10.1016/j.cell.2008.04.001. PMC 2732113. PMID 18423194.
  50. ^ Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T (2008). "Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters". Cell. 132 (5): 875–86. doi:10.1016/j.cell.2008.02.019. PMC 2323338. PMID 18329372.
  51. ^ Xiao C, Srinivasan L, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K (2008). "Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes". Nat Immunol. 9 (4): 405–14. doi:10.1038/ni1575. PMC 2533767. PMID 18327259.
  52. ^ Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, Li X (2008). "miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130". Proc Natl Acad Sci U S A. 105 (8): 2889–94. Bibcode:2008PNAS..105.2889W. doi:10.1073/pnas.0800178105. PMC 2268555. PMID 18287052.
  53. ^ Xu W, Li JY, Shen QD, Li L, Yu H (2007). "[DNA sequencing of miR-17-92 cluster at chromosome 13q31-q32 in mantel cell lymphoma cell lines]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 15 (5): 986–8. PMID 17956675.
  54. ^ Boggs RM, Moody JA, Long CR, Tsai KL, Murphy KE (2007). "Identification, amplification and characterization of miR-17-92 from canine tissue". Gene. 404 (1–2): 25–30. doi:10.1016/j.gene.2007.08.015. PMID 17904311.
  55. ^ Lu Y, Thomson JM, Wong HY, Hammond SM, Hogan BL (2007). "Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells". Dev Biol. 310 (2): 442–53. doi:10.1016/j.ydbio.2007.08.007. PMC 2052923. PMID 17765889.
  56. ^ Tagawa H, Karube K, Tsuzuki S, Ohshima K, Seto M (2007). "Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development". Cancer Sci. 98 (9): 1482–90. doi:10.1111/j.1349-7006.2007.00531.x. PMC 11159226. PMID 17608773. S2CID 26390039.
  57. ^ Matsubara H, Takeuchi T, Nishikawa E, Yanagisawa K, Hayashita Y, Ebi H, Yamada H, Suzuki M, Nagino M, Nimura Y, Osada H, Takahashi T (2007). "Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92". Oncogene. 26 (41): 6099–105. doi:10.1038/sj.onc.1210425. PMID 17384677.
  58. ^ Rinaldi A, Poretti G, Kwee I, Zucca E, Catapano CV, Tibiletti MG, Bertoni F (2007). "Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphoma". Leuk Lymphoma. 48 (2): 410–2. doi:10.1080/10428190601059738. PMID 17325905. S2CID 2941415.
  59. ^ Venturini L, Battmer K, Castoldi M, Schultheis B, Hochhaus A, Muckenthaler MU, Ganser A, Eder M, Scherr M (2007). "Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells". Blood. 109 (10): 4399–405. doi:10.1182/blood-2006-09-045104. PMID 17284533.
  60. ^ Novotny GW, Sonne SB, Nielsen JE, Jonstrup SP, Hansen MA, Skakkebaek NE, Rajpert-De Meyts E, Kjems J, Leffers H (2007). "Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster". Cell Death Differ. 14 (4): 879–82. doi:10.1038/sj.cdd.4402090. PMID 17218954.
  61. ^ Hossain A, Kuo MT, Saunders GF (2006). "Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA". Mol Cell Biol. 26 (21): 8191–201. doi:10.1128/MCB.00242-06. PMC 1636750. PMID 16940181.
  62. ^ Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y, Takahashi T (2005). "A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation". Cancer Res. 65 (21): 9628–32. doi:10.1158/0008-5472.CAN-05-2352. PMID 16266980.
  63. ^ Sawera M, Gorodkin J, Cirera S, Fredholm M (2005). "Mapping and expression studies of the mir17-92 cluster on pig chromosome 11". Mamm Genome. 16 (8): 594–8. doi:10.1007/s00335-005-0013-3. PMID 16180141. S2CID 11081775.
  64. ^ Shen J, Ambrosone CB, Zhao H (2009). "Novel genetic variants in microRNA genes and familial breast cancer". Int J Cancer. 124 (5): 1178–82. doi:10.1002/ijc.24008. PMID 19048628.

Read other articles:

Keuskupan Tagum

Keuskupan TagumDiœcesis TagamnaDiyosesis ng TagumKatolik Katedral Kristus RajaLokasiNegara FilipinaWilayahDavao del Norte (kecuali Samal), dan Lembah CompostelaProvinsi gerejawiDavaoStatistikLuas8.129 km2 (3.139 sq mi)Populasi- Total- Katolik(per 2014)1.595.0001,431,000 (89.7%)Paroki27Imam97InformasiDenominasiKatolik RomaGereja sui iurisGereja LatinRitusRitus RomaPendirian13 Januari 1962 (sebagai Prelatur)11 Oktober 1980 (sebagai Keuskupan)KatedralKate...

 

Abubakar A. Latif

Abubakar A. Latif Informasi pribadiLahir1 Juli 1965 (umur 58)Keutapang, Aceh Utara, AcehKebangsaanIndonesiaPartai politikPartai AcehKarier militerPihak Gerakan Aceh MerdekaPertempuran/perangPemberontakan di AcehSunting kotak info • L • B Teungku Abubakar A. Latif, lebih dikenal dengan nama Abu Len (lahir 1 Juli 1965) adalah tokoh pejuang GAM. Dia pernah menjabat sebagai Panglima Operasi Gerakan Aceh Merdeka Wilayah Pase. Dia pernah menjabat sebagai Anggota DPRA Fraksi Parta...

 

Bek Air Penerbangan 2100

Bek Air Penerbangan 2100Pesawat yang mengalami kecelakaan, terlihat pada tahun 2016 ketika masih terbang untuk Kam Air dengan kode registrasi UP-F1007.Ringkasan kecelakaanTanggal27 Desember 2019 (2019-12-27)RingkasanMenabrak medan saat lepas landas, dalam investigasiLokasiDekat Bandar Udara Internasional Almaty, Almaty, Kazakhstan43°21′55″N 77°04′17″E / 43.36528°N 77.07139°E / 43.36528; 77.07139Koordinat: 43°21′55″N 77°04′17″E / þ...

Chios

Island in Greece Municipality in GreeceChios ΧίοςMunicipalityChiosLocation within the region Coordinates: 38°22′39″N 26°03′54″E / 38.37750°N 26.06500°E / 38.37750; 26.06500CountryGreeceAdministrative regionNorth AegeanRegional unitChiosArea • Municipality842.3 km2 (325.2 sq mi)Highest elevation1,297 m (4,255 ft)Lowest elevation0 m (0 ft)Population (2021)[1] • Municipality5...

 

Sorrow Throughout the Nine Worlds

1996 EP by Amon AmarthSorrow Throughout the Nine WorldsEP by Amon AmarthReleased5 April 1996RecordedNovember 1995 at The AbyssGenreMelodic death metalLength24:39LabelPulverisedAmon Amarth chronology Sorrow Throughout the Nine Worlds(1996) Once Sent from the Golden Hall(1998) Sorrow Throughout the Nine Worlds is the debut EP by Swedish melodic death metal band Amon Amarth, released in April 1996 by Pulverised Records. It was originally released as a digipak limited to 1500 copies and ...

 

Operation Enduring Freedom – Horn of Africa

Military operation Operation Enduring Freedom Horn of AfricaPart of the War on Terror and the conflicts in the Horn of AfricaFrench Naval commandos (green) and United States soldiers from the 3rd Infantry Regiment (tan) participate in an exercise at Djibouti in June 2004.LocationHorn of Africa, Gulf of Aden, Guardafui ChannelResult 21 high level Al-Shabaab leaders killed[5]Belligerents  NATO  European Union  SADC  Australia  Azerbaijan  Belarus  Cana...

Buk District, Gwangju

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Buk District, Gwangju – news · newspapers · books · scholar · JSTOR (June 2019) (Learn how and when to remove this template message) Autonomous District in Honam, South KoreaBuk 북구Autonomous DistrictKorean transcription(s) • Hanja北區...

 

Winx Club season 2

Season of television series Winx ClubSeason 2 Italian DVD cover (left) and artwork for the 2011 special (right)No. of episodes26ReleaseOriginal networkRai Due4Kids TVNickelodeon (2011 special)Original release19 April (2005-04-19) –14 July 2005 (2005-07-14)Season chronology← PreviousSeason 1Next →Season 3List of episodes The second season of the animated series Winx Club aired from 19 April to 14 July 2005, consisting of 26 episodes. The series was created by Ig...

 

Burqa

Garment worn by some Muslim women This article is about the Muslim cultural garment. For other uses, see Burka. For the mask covering the eyebrows and upper lip used in Gulf countries, see Battoulah. A painting of Burqa clad Afghan women in Kabul, 1840 Part of a series onIslamic female dress Types Abaya Battoulah Boshiya Burkini Burqa Çarşaf Chador Haik Hijab Jilbaab Kerudung Kimeshek Kurhars Mukena Niqaab Paranja Safseri Selendang Shayla Tudong Yashmak Practice and law by country Australia...

Lion of Knidos

Ancient Greek statue Lion of KnidosLion of KnidosMaterialMarbleSize2.89 m long by 1.82 m highCreatedc. 350–200 BCPresent locationBritish Museum, LondonRegistration1859,1226.24 The Lion of Knidos is the name for a colossal ancient Greek statue erected near the ancient port of Knidos, south-west Asia Minor (now near Datça in Turkey). Although there is some debate about the age of the sculpture, in general, scholarly opinion dates it to the 2nd century BC. Since 2000, it has been promin...

 

大字 (数字)

この項目には、一部のコンピュータや閲覧ソフトで表示できない文字が含まれています（詳細）。 数字の大字（だいじ）は、漢数字の一種。通常用いる単純な字形の漢数字（小字）の代わりに同じ音の別の漢字を用いるものである。 概要 壱万円日本銀行券（「壱」が大字） 弐千円日本銀行券（「弐」が大字） 漢数字には「一」「二」「三」と続く小字と、「壱」「�...

 

روث ويلسون

روث ويلسون (بالإنجليزية: Ruth Wilson)‏  معلومات شخصية الميلاد 13 يناير 1982 (العمر 42 سنة)ميدلسكس، إنجلترا مواطنة المملكة المتحدة  العشير جود لو  أقرباء ألكسندر ويلسون (جد)دينيس ويلسون  [لغات أخرى]‏ (عم)  الحياة العملية المدرسة الأم جامعة نوتنغهامأكاديمية لندن للمو...

الحسن بن عبد الله العيوني

الحسن بن عبد الله العيوني درهم عيوني يعود لعهد الحسن بن عبد الله العيوني معلومات شخصية تاريخ الوفاة سنة 1154   مواطنة الدولة العيونية  الأولاد شكر بن الحسن العيونيعلي بن الحسن العيونيالزير بن الحسن العيوني  الأب عبد الله بن علي العيوني  إخوة وأخوات علي بن عبد الله �...

 

Blissymbols

Ideographic writing system For the computer language, see BLISS. BlissymbolsScript type Ideographic Time period1949 to the presentDirectionVariesLanguagesBlissymbolsISO 15924ISO 15924Blis (550), ​Blissymbols Blissymbols (world language)Created byCharles K. BlissDate1949Setting and usageAugmentative and Alternative CommunicationPurposeConstructed language International auxiliary languagePasigraphyBlissymbolsSourcesIdeographic written languageOfficial statusRegulated byBli...

 

Fokker F.11

Artikel ini perlu diwikifikasi agar memenuhi standar kualitas Wikipedia. Anda dapat memberikan bantuan berupa penambahan pranala dalam, atau dengan merapikan tata letak dari artikel ini. Untuk keterangan lebih lanjut, klik [tampil] di bagian kanan. Mengganti markah HTML dengan markah wiki bila dimungkinkan. Tambahkan pranala wiki. Bila dirasa perlu, buatlah pautan ke artikel wiki lainnya dengan cara menambahkan [[ dan ]] pada kata yang bersangkutan (lihat WP:LINK untuk keterangan lebih lanjut...

Prelatur Teritorial Santiago Apóstol de Huancané

Prelatur Teritorial Santiago Apóstol de HuancanéPraelatura Territorialis Iacobus Apostolus HuancanensisKatedral Santiago ApóstolLokasiNegara PeruProvinsi gerejawiArequipaStatistikLuas18.881 km2 (7.290 sq mi)Populasi- Total- Katolik(per 2019)200.489170,415 (85.0%)InformasiRitusRitus LatinKatedralKatedral Santiago Apóstol di HuancanéKepemimpinan kiniUskupGiovanni Cefai, M.S.S.P. Prelatur Teritorial Santiago Apóstol de Huancané (bahasa Latin: Pr...

 

埼玉県警運転免許センター

埼玉県警察運転免許センター（2006年12月） 埼玉県警察運転免許センター（さいたまけんけいさつうんてんめんきょセンター）は、埼玉県鴻巣市にある、埼玉県警察が管理する運転免許試験場である。 施設概要 運転免許試験コース（2012年6月） 運転免許の学科試験や技能試験や限定解除審査は勿論、運転免許証の発行・更新・再交付、国際運転免許証の発行も行われて�...

 

Lin Tinggui

Luohan sedang Mencuci, karya Lin Tinggui, 1178 Masehi Lin Tinggui (Hanzi: 林庭珪; Pinyin: Lín Tíngguì; Wade–Giles: Lin T'ing-kuei; fl. sekitar 1174–1189) (Jepang: Rin Teikei) adalah seorang pelukis Tiongkok dari Dinasti Song Selatan (1127–1279 M). Karya seninya sangat dipengaruhi oleh tema-tema Buddha Tiongkok. Lima Ratus Luohan Lin Tinggui dikenal karena mengambil bagian bersama dengan Zhou Jichang (Jepang: Shuu Kijou) dalam penyelesaian Lima Ratus Luohan (Tionghoa: W...

Watagan Mountains

Watagan MountainsWatagans or Wattagan MountainsMount Warrawolong as viewed from Wattagan Creek Road, LagunaHighest pointPeakMount Warrawolong, Upper Hunter regionElevation641 m (2,103 ft)AHDCoordinates33°02′S 151°15′E / 33.033°S 151.250°E / -33.033; 151.250[1]GeographyWatagan MountainsLocation in New South Wales LocationHunterCentral CoastCountryAustraliaStateNew South WalesRange coordinates31°42′S 151°42′E / 31...

 

Doxycycline

DoxycyclineDữ liệu lâm sàngPhát âm/ˌdɒksɪˈsaɪkliːn/DOKS-i-SY-kleen Tên thương mạiDoryx, Doxyhexal, Doxylin among othersAHFS/Drugs.comChuyên khảoMedlinePlusa682063Giấy phép US FDA: Doxycycline Danh mục cho thai kỳ AU: D US: D (Bằng chứng về rủi ro) Dược đồ sử dụngqua đường miệng, tiêm tĩnh mạch[1]Mã ATCJ01AA02 (WHO) A01AB22 (WHO)Tình trạng pháp lýTình trạng pháp lý AU...