Waterman is one of the founders and current leaders in the area of computational biology. He focuses on applying mathematics, statistics, and computer science techniques to various problems in molecular biology. His work has contributed to some of the most widely used tools in the field. In particular, the Smith-Waterman algorithm (developed with Temple F. Smith) is the basis for many sequence alignment programs.[9] In 1988, Waterman and Eric Lander published a landmark paper describing a mathematical model for fingerprint mapping.[10] This work formed one of the theoretical cornerstones for many of the later DNA mapping and sequencing projects, especially the Human Genome Project. A 1995 paper by Idury and Waterman introduced Eulerian-De Bruijn sequence assembly which is widely used in next-generation sequencing projects.[11]
Waterman has written a memoir, Getting Outside,[7] of a childhood spent on an isolated livestock ranch on the southern coast of Oregon in the mid-20th century.
^ abWaterman, Michael (2016). Getting Outside: A Far-Western Childhood. CreateSpace Independent Publishing Platform. ISBN978-1530929344.
^Waterman, Michael Smith (1969). Some Ergodic Properties of Multi-Dimensional F-Expansions (PhD thesis). Michigan State University. OCLC25799203. ProQuest302449931. (subscription required)
^Waterman, Michael R.; Waterman, M. S. (1995). Introduction to computational biology: maps, sequences and genomes. London: Chapman & Hall. ISBN978-0-412-99391-6.