Chris Sander (scientist)

Chris Sander
Chris Sander speaking at ISMB in 2010
Born
Germany
Alma materUniversity of Berlin
University of California, Berkeley[5]
Known forBioinformatics
Computational biology
Cancer genomics[6]
RelativesOtto Sander (brother)
Awards
Scientific career
InstitutionsDana Farber Cancer Institute[2]
Memorial Sloan–Kettering Cancer Center
Rockefeller University
Cornell University
Weizmann Institute of Science[3]
ThesisAnalytic properties of bound state wave functions (1975)
Doctoral students
Websitewww.sanderlab.org#/people/chrissander

Chris Sander is a computational biologist based at the Dana-Farber Cancer Center and Harvard Medical School. Previously he was chair of the Computational Biology Programme at the Memorial Sloan–Kettering Cancer Center in New York City.[7][8][9][10][11][12][13] In 2015, he moved his lab to the Dana–Farber Cancer Institute[14] and the Cell Biology Department at Harvard Medical School.[15]

Education

Sander originally trained as a physicist, receiving his undergraduate degree from the University of Berlin in 1967.[2] After a period studying at the University of California, Berkeley and the Niels Bohr Institute in Copenhagen,[2][16] he gained his PhD degree in theoretical physics from the State University of New York in 1975. His thesis was titled Analytic properties of bound state wave functions.[17]

Research

Sander credits his move from theoretical physics to computational biology to Fred Sanger's 1977 landmark paper in Nature,[18] in which the nucleotide sequence of bacteriophage φX174 was published.[2] Sander has made many contributions to the field of structural bioinformatics including developing tools such as the Families of Structurally Similar Proteins (FSSP) database[19] and the DSSP algorithm for assigning secondary structure to the amino acids of a protein, given the atomic-resolution coordinates of that protein.[20]

Sander was a founder of the biocomputing program at the European Molecular Biology Laboratory in Heidelberg, before moving the program to the European Bioinformatics Institute in Cambridge. He has served as chief information officer for the biopharmaceutical company Millennium Pharmaceuticals and has been an advisor to IBM's Deep Computing Initiative, which produced the Deep Blue chess computer.[21]

Awards and honours

Sander is a former Executive Editor for the journal Bioinformatics. In 2014 he was appointed one of the first Honorary Editors of Bioinformatics.[22]

Sander was awarded the ISCB Accomplishment by a Senior Scientist Award in 2010.[16] He was awarded the 2018 DeLano Award for Computational Biosciences.[23]

Personal life

Sander is the brother of German actor Otto Sander.[24]

References

  1. ^ McKay, B. M.; Sansom, C. (2010). "2010 ISCB Overton Prize Awarded to Steven E. Brenner". PLOS Computational Biology. 6 (6): e1000831. Bibcode:2010PLSCB...6E0831M. doi:10.1371/journal.pcbi.1000831. PMC 2891695. PMID 20585610.
  2. ^ a b c d "Sander Lab".
  3. ^ Lifson, Shneior; Sander, Christian (1979). "Antiparallel and parallel β-strands differ in amino acid residue preferences". Nature. 282 (5734): 109–111. Bibcode:1979Natur.282..109L. doi:10.1038/282109a0. PMID 503185. S2CID 4284088.
  4. ^ Ouzounis, Christos (1993). The role of sequence conservation in the prediction of protein structure (PhD thesis). University of York. OCLC 53486615. EThOS uk.bl.ethos.387193.
  5. ^ "At Work: Computational Biology Program Chair Chris Sander | Memorial Sloan-Kettering Cancer Center". Archived from the original on 2013-02-21.
  6. ^ Holm, L.; Sander, C. (1993). "Protein Structure Comparison by Alignment of Distance Matrices". Journal of Molecular Biology. 233 (1): 123–138. doi:10.1006/jmbi.1993.1489. PMID 8377180. S2CID 9040631.
  7. ^ Chris Sander at DBLP Bibliography Server Edit this at Wikidata
  8. ^ Chris Sander publications indexed by Google Scholar Edit this at Wikidata
  9. ^ Chris Sander publications indexed by Microsoft Academic
  10. ^ Sander, Chris A.'s publications indexed by the Scopus bibliographic database. (subscription required)
  11. ^ John, B.; Enright, A. J.; Aravin, A.; Tuschl, T.; Sander, C.; Marks, D. S. (2004). "Human MicroRNA Targets". PLOS Biology. 2 (11): e363. doi:10.1371/journal.pbio.0020363. PMC 521178. PMID 15502875.
  12. ^ Rost, B.; Sander, C. (1993). "Prediction of Protein Secondary Structure at Better than 70% Accuracy". Journal of Molecular Biology. 232 (2): 584–599. CiteSeerX 10.1.1.17.1418. doi:10.1006/jmbi.1993.1413. PMID 8345525.
  13. ^ Sander, C.; Schulz, G. E. (1979). "Degeneracy of the information contained in amino acid sequences: Evidence from overlaid genes". Journal of Molecular Evolution. 13 (3): 245–252. Bibcode:1979JMolE..13..245S. doi:10.1007/BF01739483. PMID 228047. S2CID 22606882.
  14. ^ "Chris Sander, PhD - DF/HCC". www.dfhcc.harvard.edu. Retrieved 2019-01-01.
  15. ^ "Chris Sander | Department of CELL BIOLOGY". cellbio.med.harvard.edu. Retrieved 2019-01-01.
  16. ^ a b "2010 Accomplishment by a Senior Scientist Award - Chris Sander".
  17. ^ Sander, C. (1975). "INIS Collection Search - Single Result". p. 155. Retrieved 13 August 2015.
  18. ^ Sanger, F.; Air, G. M.; Barrell, B. G.; Brown, N. L.; Coulson, A. R.; Fiddes, J. C.; Hutchison, C. A.; Slocombe, P. M.; Smith, M. (24 February 1977). "Nucleotide sequence of bacteriophage φX174 DNA". Nature. 265 (5596): 687–695. Bibcode:1977Natur.265..687S. doi:10.1038/265687a0. PMID 870828. S2CID 4206886.
  19. ^ Holm L, Ouzounis C, Sander C, Tuparev G, Vriend G (1992). "A database of protein structure families with common folding motifs". Protein Science. 1 (12): 1691–1698. doi:10.1002/pro.5560011217. PMC 2142138. PMID 1304898.
  20. ^ Kabsch, W.; Sander, C. (1983). "Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features". Biopolymers. 22 (12): 2577–2637. doi:10.1002/bip.360221211. PMID 6667333. S2CID 29185760.
  21. ^ "Bio-IT World: Horizons - Chris Sander". Archived from the original on 23 September 2015. Retrieved 13 August 2015.
  22. ^ "15 years of "Bioinformatics"". Bioinformatics. 30 (6): 747. 2014. doi:10.1093/bioinformatics/btu076. PMID 24642573.
  23. ^ "DeLano Award for Computational Biosciences". www.asbmb.org. Retrieved 15 September 2017.
  24. ^ Biography for Otto Sander at IMDb. Retrieved 13 August 2015.