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In addition to the archetypical mad scientist, there are fictional characters who are scientists and engineers who go above and beyond the regular demands of their professions to use their skills and knowledge for the betterment of others, often at great personal risk. This is a list of fictional scientists and engineers, an alphabetical overview of notable characters in the category.
Captain Jaylen Cresida (The Lost Fleet) - The captain in the Alliance Navy under the command of Captain John "Black Jack" Geary, and an expert on hypernet gates.
Dr. Claire Deller (I, Robot and other stories by Isaac Asimov) - The chief robot genius of San Diego Robots and Mechanical Men.
Leonid Gorbovsky (Noon Universe) - A genius scientist, progressor and spaceship captain, known for his ability to land on planets to survive planet-wide catastrophes and make contact with alien civilizations.
Leo Graf (Falling Free) - A space engineer who leads a group of genetically engineered four-armed humans known as "quaddies" to freedom.
Gennady Komov (Noon Universe) - A xenopsychologist whose main occupation is making contact with and studying alien civilizations.
Col John "Renny" Renwick (Doc Savage) - A civil engineer and associate of Doc Savage.
Maj Thomas J. "Long Tom" Roberts (Doc Savage) - An electrical engineer and associate of Doc Savage.
Dr. Clark Savage, Jr., aka. Doc Savage (Doc Savage) - A surgeon, scientist, adventurer, inventor, explorer, and musician.
Arne Saknussemm (Journey to the Center of the Earth) - A 16th-century Icelandic naturalist, alchemist, and traveler whose messages guide a group of 19th-century adventurers.
Professor Shonku (Byomjatrir Diary, Professor Shonku o Robu, Professor Shonku o Khoka, Professor Shonku o Corvus, Ek Sringo Obhijaan, Swarnaparni and other works by Satyajit Ray) - The world's most respected scientist and inventor and a physics professor at Scottish Church College. He invents several inventions while going on adventures he records in his diary.
Sebastian Caine (Hollow Man) - A scientist part of a team that worked on an invisibility serum and its antidote, tested on animals. He goes insane when the invisibility serum tested on him became irreversible.
Jackson Curtis (2012) - A struggling science-fiction writer.
Adrian Helmsley (2012) - A geologist and chief science advisor to U.S. President Thomas Wilson.
Dr. Newton Geiszler (Pacific Rim) - K-Science Officer in the biologist/research team.
Dr. Hermann Gottlieb (Pacific Rim) - K-Science Officer in the mathematician/research team.
Dr. Stanley Goodspeed (The Rock) - AFBI chemical weapons specialist.
Corporal Hardin (Southern Comfort) - A chemical engineer on weekend maneuvers with Louisiana Army National Guard squad in rural bayou country as they antagonize and are hunted down by the local Cajun people. His day job is only relevant to explain his rational sensible approach.
Ian Malcolm (Jurassic Park) - A mathematician and chaotician who survives several encounters with dinosaurs and other hazards. His mathematical prowess allows him to predict his own fate and that of the park's inhabitants.
Q (James Bond) - He makes the gadgets that James Bond uses; he is most often portrayed using the conventional literary trappings of a scientist, such as a white lab coat, though his activities are closer to engineering.
Mark Watney (The Martian) - A botanist, mechanical engineer, and astronaut.
Dr. William Weir (Event Horizon) - The designer of the titular spacecraft and its FTL propulsion system, the gravity drive.
Steve Zissou (The Life Aquatic with Steve Zissou) - An eccentric oceanographer who sets out to exact revenge on a shark referred to as a "jaguar shark".
In live-action television
Individual scientist/engineers in live-action television
Beakman (Beakman's World) - A general scientist who, in a funny and entertaining manner, teaches that science is a fact of life.
Walter White (Breaking Bad) - A former chemist who, after being diagnosed with terminal lung cancer, begins manufacturing meth to provide for his family.
Carson Beckett (Stargate Atlantis) - A medical doctor and geneticist who discovers the ATA gene and serves as the chief medical officer for the Atlantis expedition.
Sam Beckett (Quantum Leap) - A Nobel Prize-winning quantum physicist with multiple doctorates who is caught in his own time-travel experiment; "leaping" into many lives along the span of his own lifetime. He must change the histories of those around him for the better before he can return home.
Ravi Chakrabarti (iZombie) - A medical examiner for the Seattle PD. He has studied the biology of zombies and made several attempts to develop a cure for the condition.
Professor Monty Corndog (The Aquabats / The Aquabats! Super Show!) - An eccentric scientist and inventor whose chemical creations transforms a group of ordinary men into the titular superheroes and rock musicians, who fight crime with the aid of the Professor's gadgets.
Beverly Crusher (Star Trek: The Next Generation) - The chief medical officer of the Enterprise-D.
Data (Star Trek: The Next Generation) - The second officer and chief operations officer of the Enterprise-D, whose duties cover that of a science officer.
Davros (Doctor Who) - A Universal Genius from the planet Skaro and nemesis of the Doctor. He invented the Reality Bomb - a moon-sized machine which creates a wavelength with the ability to cancel the electrical field that holds atoms together using the Reality Bom, who intended to use it to destroy all life in the universes.
Jadzia Dax (Star Trek: Deep Space Nine) - A science officer on Deep Space Nine.
Ezri Dax (Star Trek: Deep Space Nine) - A counselor on Deep Space Nine.
Professor Roy Hinkley (Gilligan's Island) - The respected de facto leader of the castaways. who usually represents the only real continual hope of rescue. He can make anything out of bamboo and coconuts, but cannot find a way to fix the S.S. Minnow or build a working boat.
Dr. Elias Huer (Buck Rogers) - The chief scientist and inventor in the comic strip, movie serial and television series.
Dr. Daniel Jackson (Stargate) - An archaeologist and linguist who figures out how to open the Stargate; his understanding of cultures and languages comes in handy when dealing with other cultures.
Seven of Nine (Star Trek: Voyager) - A Borg drone with no official rank or post, but was used as an acting science officer on Voyager due to her access to advanced Borg knowledge.
Aviva Corcovado (Wild Kratts) - An engineer and inventor who works with the Kratt brothers. Among other inventions, she created the Creature Power Suits, which mimic the abilities of animals.
Dexter (Dexter's Laboratory) - A child genius who invents world-saving inventions in his secret laboratory.
Professor Hubert Farnsworth (Futurama) - The creator of an atomic monster, various inventions, and the engines that allow space travel.
Franz Hopper (Code Lyoko) - A genius in quantum physics and computer programming responsible for the creation of the virtual reality Lyoko, malevolent A.I. XANA, and the hardware that supports both.
Rick Sanchez (Rick and Morty) - A sociopathic alcoholic and the smartest man of the universe, who travels through various dimensions with his grandson Morty.
Asami Sato (The Legend of Korra) - A trained engineer, skilled pilot and driver, and competent unarmed combatant; partner of Avatar Korra and CEO of Future Industries.
Carter Hall / Hawkman - An archaeologist who has been reborn many times, using his knowledge acquired through centuries in his anthropological studies.
Mar Londo - A Zuunian scientist who experimented with the element zuunium and created robots to mine it. He gave his son, Brin Londo, superpowers using zuunium and died shortly afterward.[1][2][3]
Will Magnus - The creator of the Metal Men, a team of advanced artificially-intelligent robots.
Jon Osterman / Doctor Manhattan - A nuclear physicist transformed by an accident into a godlike super-being. While publicized as a superhero, Manhattan functions as the ultimate weapon for the United States military and works as one of their sanctioned superheroes.
Ray Palmer / Atom - A physics professor at Ivy University; he is able to shrink his body to varying degrees, including sub-atomic level.
Bruce Wayne / Batman - Reputedly the world's greatest detective, Batman possesses unsurpassed scientific knowledge and forensic and memory skills.
Marvel Comics
Dr. Bruce Banner / Hulk - A scientist who developed a gamma bomb for the US government. An accident at the site of a test led to Banner becoming the Hulk; afterwards, he looked for scientific ways to rid himself of the transformation.
Ted Sallis - A biochemist who was transformed into the Man-Thing following a failed attempt to recreate the serum that created Captain America. Although struggling with his personal ethics regarding women and girls, he abandoned Operation Sulfer on moral grounds and elected to remain as Man-Thing rather than allow innocents to be killed by the demon Thog.
Tony Stark / Iron Man - An industrialist and mechanical engineer of incredible ingenuity and inventive genius, whose technology he uses to fight crime also keeps him alive.
Dr. Henry "Hank" Pym - A biochemist, who discovers an unusual set of subatomic particles he names Pym Particles. Entrapping the particles within two separate serums, he creates a size-altering formula and a reversal formula, testing them on himself and becoming the original Ant-Man.
Brainstorm (The Transformers: More than Meets the Eye) - A scientific genius who invented time travel in order to save his best friend's husband, the consequences of which technically began the Autobot-Decepticon civil war.
Professor Cuthbert Calculus (The Adventures of Tintin) - A brilliant, if distracted, scientist; responsible for developing the first one-person submarine, the first ultrasonic destruction device, and the first white rose, as well as the leader of the first crewed lunar mission.
Dilbert - A star engineer of the comic strip series Dilbert.
Jeremias Gobelijn (Jommeke) - The self-declared "professor in everything".
Agatha Heterodyne (Airship Entertainment and Girl Genius) - An heiress to the political background and scientific understanding of the Heterodyne family.
Bulma (Dragon Ball) - The creator of the Dragon Radar and a time machine, which allowed Trunks to travel back in time and avert the conquest of the world by evil androids.
Dr. Cinnamon (TwinBee) - A genius scientist who is the creator of TwinBee and WinBee.
Caesar Clown (One Piece) - The former marine scientist and former partner of Doctor Vegapunk. He created mass destruction weapons and human experimentation, but was fired and arrested due to his unethical research methods.
The Doctor (Hellsing) - The lead scientist of Millennium, who created the Nazi vampires and the catboy Schrödinger.
Jotaro Kujo (JoJo's Bizarre Adventure) - An oceanographer. While unrelated to his role in the various plot arcs he appears in, Jotaro earns a doctorate in oceanography sometime during the summer of 1999 in the series' original timeline, and dolphin and anchor motifs were added to his clothing to reflect his new occupation.
Makise Kurisu (Steins;Gate) - A neuroscientist who graduated from university at the age of 17, inspired by her father's work to write a thesis on time travel. She currently works as a researcher at the Viktor Chondria University in the United States.
Dr. Emil Lang (Robotech) - He was responsible for much of the Earth-based Robotechnology; briefly seen in the original series, he played a much larger role in Robotech II: The Sentinels.
Doctor Vegapunk (One Piece) - The leading scientist in the employment of the Marines. His work includes discovering the secrets and uses of Seastone, the secrets of how Devil Fruit powers work, how to get an item to "eat" a Devil Fruit, and other futuristic inventions.
Hanji Zoe (Attack on Titan) - The head scientist in the survey corps, who performs experiments on captured titans in hopes of finding a way to save humanity.
In video games
Scientists in video games
Dr. Alphys (Undertale) - A timid lizard monster and Asgore's royal scientist, who is the creator of the robot Mettaton and the Amalgamates. She has a crush on Undyne, captain of the Royal Guard.
Dr. Andonuts (EarthBound) - The father of Jeff, one of the Chosen Four.
Dr. Alex Mercer ([PROTOTYPE]) - The creator of the Blacklight virus.
Rikako Asakura (Touhou Project) - Known as the "Scientist Searching for Dreams", she is one of the few people in Gensokyo to value using science over magic. Though occasionally using magic in order to enhance her science, she tries to refrain from using magic due to her natural distaste of it.
Coco Bandicoot (Crash Bandicoot) - Crash Bandicoot's younger sister. who has a deep intelligence and a love of science. This is in opposition to her brother, an electronics engineer specializing in hacking, computer programming and machine building.
Nicoletta "Nico" Goldstein (Devil May Cry) - Creator of various robotic arms that the player can use when playing as Nero.
Catherine Halsey (Halo) - The scientist of the Office of Naval Intelligence and creator of Cortana and the SPARTAN-II Program and Mjolnir Powered Assault Armor, as well as supervising the creation of the template for third-generation smart AI.
Dr. Samuel Hayden (Doom) - Head of the UAC, physicist.
Kirin Jindosh (Dishonored 2) - Grand Inventor to Duke Luca Abele and founder of Jindosh Clockworks, which created the Clockwork Soldiers and Clockwork Sentinels.
Cave Johnson (Portal 2) - The eccentric former owner of Aperture Science, and creator of the portal gun.
Plague Knight (Shovel Knight) - A rogue member of the Order of No Quarter, who tries to harvest their Essence for the Ultimate Potion to win over someone's heart.
Dr. Krieger (Far Cry) - A renowned scientist and creator/controller of the Trigens in the first Far Cry game
Love Lab scientists (Rhythm Heaven) - A male and female scientist who pass ingredients to each other to make love potions to the rhythm of the music
Kurisu Makise (Steins;Gate) - A Japanese neuroscientist who lives in the United States, who builds a machine that allows the user's memories to be converted into data.
Mei (Overwatch) - A climatologist and one of the heroes in the games and comic series.
Moira (Overwatch) - A geneticist and one of the playable heroes in the game.
Daro'Xen vas Moreh (Mass Effect 2) - A Quarian admiral and scientist who believes that the geth, a synthetic race created by the quarians, who rebelled and drove their masters from their homeworld, should be controlled by the quarians once again. Admiral Xen also performed surgery on her childhood toys, much to the quarian squadmate Tali'Zorah's disgust.
Tobias Planck (Pirate Galaxy) - Named after Max Planck, he is a theoretical physicist and field scientist with a parietal lobe 15% larger than average.
Egon Stetmann (StarCraft II) - The creator of the Mecha Swarm, who is paranoid and prone to terrazine-induced hallucinations. He was once chief science adviser aboard the Hyperion.
Dr. Yi Suchong (Bioshock) - A scientist in the city of Rapture, known for creating the Big Daddies, plasmids such as telekinesis and enrage, and helping to turn Jack into Frank Fontaine's "ace in the hole".
Grimoire Valentine (Final Fantasy VII) - A Shinra scientist and Vincent Valentine's father.
Wilhelm "Doktor" Voigt (Metal Gear Rising: Revengeance) - A robotics engineer working for Maverick Security Consulting, who assists the player throughout the game.
Reed Wahl (BioShock 2) - The co-founder of Rapture Central Computing, and co-inventor of the Thinker, main antagonist of the Minerva's Den DLC.
Albert Wesker (Resident Evil) - A microbiologist working for the pharmaceutical enterprise Umbrella and co-creator of the T-virus. He was killed in the first Resident Evil game by Tyrant T-002, a powerful biological weapon, but resurrected with super-human powers via the T-virus.
Cid (Final Fantasy) - A recurring character throughout the series, often with the occupation of engineer.[5][6]
Isaac Clarke (Dead Space) - A space engineer tasked with investigating the U.S.G. Ishimura, and later fighting the Necromorphs.[7][8]
The Engineer (Deep Rock Galactic) - A dwarf engineer and employee of the Deep Rock Galactic corporation.
The Engineer (Team Fortress 2) - One of nine playable classes who is capable of building sentry guns for area denial and other constructions that support allies.[9]
This section lists all the mad scientists in different media appearances:
Mad scientists and evil geniuses in literature
Otto Hantzen (Les Mystères de Demain) - A German mad scientist, who, along with female accomplice Hindu mystic Yogha, battles his former colleague Oronius from Mount Everest to Atlantis.
Dr. Henry Jekyll (Strange Case of Dr Jekyll and Mr Hyde) - A scientist who searches for alteration of the human body and to separate the evil from the good, which led to him developing the evil form of Edward Hyde.
Dr. Moreau (The Island of Doctor Moreau) - A vivisectionist who has fled a scandal to live on a remote island in the Pacific to pursue his research of perfecting his Beast Folk.
Professor Gerard Beckert (Frostbite) - A mad geneticist and Nazi World War II veteran who creates genetically enhanced vampires out of the unsuspecting youth of a Norrland-town near the Arctic Circle.
Dr. Franz Edelmann (House of Dracula) - A honorable doctor who was transfused with the blood of Count Dracula, causing him to go insane and become a murderer.
Casanova Frankenstein (Mystery Men) - A criminal mastermind in Champion City.
Frederick Frankenstein (Young Frankenstein) - The grandson of Victor Frankenstein, who at first is embarrassed by his grandfather's deeds and insists that his name is pronounced "Fronkensteen," but eventually creates his own monster.
Henry Frankenstein (Frankenstein) - The film's version of Victor Frankenstein.
Dr. Golden Glory (The 5th Monkey) - A deranged but brilliant Brazilian scientist who repeatedly attempts to torture monkeys in the hopes of curing autism.
Dr. Lawrence Gordon (Saw) - An uncaring surgeon until he survived a "test" orchestrated by the Jigsaw Killer. After the experience changed his viewpoint on life, Gordon became Jigsaw's apprentice and began applying his medical skills to Jigsaw's traps. Following Jigsaw's death, Gordon became his successor.
Doctor Septimus Pretorius (Bride of Frankenstein) - A mad doctor and Henry Frankenstein's teacher who followed in Henry Frankenstein's footsteps in creating living beings. He blackmailed Frankenstein into helping him to create a female companion for Frankenstein's monster.
Dr. Shinzo Mafune (Terror of Mechagodzilla) - A bitter oceanographer who had previously been ridiculed for his obsessive research into the brain patterns of sea creatures. He allies with the invading Black Hole Planet 3 Aliens, unleashing the mind-controlled kaijuTitanosaurus - whom he had personally discovered - to assist their newly-rebuilt Mechagodzilla.
Dr. Carl Stoner (Sssssss) - A delusional scientist attempting to create a method of transforming humans into snakes.
Walter Bishop (Fringe) - A scientist who was responsible for opening a doorway into another universe to save an alternate version of his son Peter from dying. His actions resulted in the gradual breakdown of both universes and inadvertently started a war between them.
Professor Bug (The Backyardigans) - A pseudo-steampunk mad scientist portrayed by Pablo, who bugs all the robots in Mega City in the episode "Robot Rampage".
Dr. Cerebral (Atomic Betty) - A mad alien scientist, consisting of a brain with a face floating within a glass tank upon a mechanical body, who seeks to control the universe and wipe out all organic life out of a belief that mechanical beings are more efficient.
Dr. Flug (Villainous) - An intelligent and inventive mad scientist who creates the gadgets and machines that Black Hat attempts to sell.
Mojo Jojo (The Powerpuff Girls) - A mad scientist chimpanzee that plots to take over the world and destroy the Powerpuff Girls. He was also Professor Utonium's former pet and partially responsible for the creation of the Powerpuff Girls.
Van Kleiss (Generator Rex) - A British scientist who can manipulate the earth.
Dr. Lullah (StuGo) - She was responsible for turning animals into humanoid mutants, creating other lifeforms, and conducting experiments, as well as passing her island off as a summer camp that six children attend.
Mandark (Dexter's Laboratory) - Dexter's rival, an evil genius who wants to destroy Dexter's laboratory and take over the world.
Dr. Alphonse Mephesto (South Park) - A mad scientist who specializes in genetic engineering and creates strange creatures with his talents. He also performs experiments ranging from simple DNA tests to creating a genetic clone of Stan Marsh for his son's science project.
Dr. Cinnamon J Scudworth (Clone High) - A mad scientist who created clones of historic figures, employed by The Secret Board of Shadowy Figures.
Dr. Anton Sevarius (Gargoyles) - A mad scientist and geneticist involved in several projects in the Gargoyles storyline. His most notable act is the creation of Talon and the Mutates.
Jack Spicer (Xiaolin Showdown) - A self-proclaimed evil boy genius.
Doctor Two-Brains (WordGirl) - A scientist who accidentally fused a mouse brain with his own, giving him an evil split personality.
Dr. Weird (Aqua Teen Hunger Force) - The smartest, maddest, and scientistest scientist in the universe, whose experiments often cause problems for the Aqua Teens.
Mad scientists in animated films
Buddy Pine / Syndrome (The Incredibles) - Mr. Incredible's fan/aspiring sidekick-turned-supervillain, who uses his scientific prowess to give himself enhanced abilities.
Dr. Hiroshi Agasa (Case Closed) - An absent-minded professor who invents several devices to aid Jimmy Kudo,
Bondrewd (Made in Abyss) - A White Whistle known as "Bondrewd the Novel", who is in charge of Idofront, the Cave Riders' forward Operating Base in the fifth layer. He was responsible for several unethical experiments on children, including the one which transformed Nanachi and Mitty into Hollows.
Dr. Hell (Mazinger Z) - A mad scientist who is obsessed with taking over the world with his army of robotic monsters known as Mechanical Beast or Kikaiju.
Senku Ishigami (Dr. Stone) - A genius with vast scientific knowledge, who is able to invent various kinds of tools and gadgets quickly and efficiently. As a child, he designed and built a functioning miniature rocket ship. Senkuu also possesses an analytical mind, being able to correctly discern the situation he is in.
Mayuri Kurotsuchi (Bleach) - A sadistic and cruel shinigami who uses his position as the leader of the Soul Society's Shinigami Research and Development Institute to conduct experiments.
Rintaro Okabe (Steins;Gate) - An eccentric yet kind-hearted inventor who embraces the typical image of a mad scientist. His experiments lead to the invention of time travel.
Orochimaru (Naruto) - A shinobi obsessed with immortality and obtaining knowledge of all jutsu. He conducted many illegal and unethical experiments that resulted in him becoming a wanted criminal.
Kaolla Su (Love Hina) - An exchange student and princess of the island of Molmol. She frequently invents dangerous devices and wants to turn her kingdom into a technological powerhouse that will conquer Japan.
Professor Souichi Tomoe (Sailor Moon) - The father of Hotaru Tomoe and the leader of Death Busters, who was once a world-renowned scientist in the field of genetic engineering. After being forced out of the scientific community for his unethical experiments, he sold his findings to companies and bought the Sankakusu District to continue his research to create "Super Beings". He vesselized one of the Daimon eggs, Germatoid, to become a human-Daimon hybrid, selling his soul to Master Pharaoh 90 and willfully discarding his humanity. After becoming a hybrid, he creates various Daimons while working to perfect the stability of Daimon/human hybrids.
Daruma Ujiko (My Hero Academia) - A mad scientist associated with the series' main antagonists, the League of Villains.
Kabuto Yakushi (Naruto) - Orochimaru's assistant who takes part in many of his master's illegal experiments in addition to conducting his own, which include raising the dead.
Mad scientists in comics
Mad scientists in DC Comics
Doctor Death - The first supervillain Batman ever faces, a chemist and producer of biological weapons.
Dollmaker - A serial killer and insane surgeon who makes dolls out of human flesh.
Curt Connors - A college professor and expert on reptiles, who created a formula to regrow his missing arm, but ended up turning himself into the Lizard.
Doctor Doom - An evil scientist, engineer, genius, and conqueror. Like Mister Fantastic, he is regarded as one of the most intelligent people on Earth.
High Evolutionary - A British scientist who specializes in mutating animals into anthropomorphic forms.
Jackal - A college professor who has a vendetta against Spider-Man due to the death of his girlfriend Gwen Stacy, whom he secretly loved. He creates multiple clones of the Spider-Man as well as a clone of Gwen to attack and torment him, eventually turning himself into a jackal-like beast.
Leader - An enemy of the Hulk who was mutated by gamma radiation and possesses superhuman intelligence.
Mister Sinister - An enemy of the X-Men who specializes in genetic engineering.
Morbius - A scientist whose experiment with vampire bat DNA turned him into a pseudo-vampire.
Norman Osborn - A billionaire CEO of Oscorp and Spider-Man's nemesis, who is sometimes portrayed as a scientist with brilliant intellect. He crafts a Halloween-themed costume called the Green Goblin while having developed a personality associated with it.
Baron Zemo - A Nazi and archenemy of Captain America.
Arnim Zola - A former Nazi scientist who escaped death by transferring his consciousness into a mechanical body. In the present day, he is a member of the Hydra terrorist organization.
Doctor Nitrus Brio (Crash Bandicoot) - A timid and meek scientist who assisted Doctor Neo Cortex in the first game, often using beakers of chemicals.
Doctor Neo Cortex (Crash Bandicoot) - An evil doctor who is the creator and archenemy of the franchise's titular hero Crash Bandicoot and has an oversized head. He seeks to conquer the world using Power Crystals.
Dr. Ivo "Eggman" Robotnik (Sonic the Hedgehog) - A mad scientist and archenemy of Sonic the Hedgehog, who specializes in robotics and other fields of engineering and invents various aircraft, robots and vehicles, imprisoning animals inside of working robotic shells and experimenting with types of mutations. He aims to capture the Chaos Emeralds.
Dr. "Mundo" Edmundo (League of Legends) - A sociopath medical doctor who specializes in the study of the pain response and how to inflict pain. His experiments have caused him to take on a monstrous form and a deceptively dimwitted speech pattern.
Doctor N. Gin (Crash Bandicoot) - A masochistic scientist who assists Neo Cortex.
Alexandria Hypatia (Dishonored 2) - The chief alchemist at the Addermire Institute who gains a separate serial killer personality after an experiment goes wrong.
GLaDOS/Caroline (Portal) - The main antagonist of the Portal franchise. She was Cave Johnson's assistant before taking over the facility.
Dr. M (Sly Cooper) - A mandrill who was the brains of Sly's father's gang. Feeling that he was being held back, he set up a fortress on Kaine Island to break into the Cooper Vault and claim the wealth for himself.
The Medic (Team Fortress 2) - One of nine playable classes, who rejects the Hippocratic Oath. He is able to heal other characters and temporarily make them invincible using his Medigun. He previously had a medical licence, but lost it due to misplacing a patient's skeleton.
Rintarō Okabe / Kyōma Hōōin (Steins;Gate) - A self-proclaimed mad scientist in his Kyōma Hōōin persona, taken from a television show he watched as a child.
General Wilhelm "Deathshead" Strasse (Wolfenstein) - The major antagonist of the series, who leads the Nazis' research projects.
Vexen (Kingdom Hearts) - A founding member of Organization XIII and the head of the Replica Program, which creates artificial humanoids that serve as vessels for hearts.
Viktor (League of Legends) - A scientist who replaced his body with a machine and wants to enhance the human race.
Dr. Wily (Mega Man) - The primary antagonist of the original Mega Man series.
Yuri (Red Alert 2) - A Soviet psychic and founder of the Psychic Corps. During World War II, he took part in Joseph Stalin's secret project, whose aim was to create mind-control technology, and an army which specialized in psychic warfare.
Henry Emily (Five Nights at Freddy's) - Henry was the creator of the springlock animatronics, and possibly the original four animatronics. He is business partners with William Afton and is the father of Charlie Emily and Sammy Emily.
Morgus the Magnificent - A horror host of late-night science fiction and horror movies and television shows that originated in the New Orleans, Louisiana market.
Professor Nebulous (Nebulous) - The leader of an eco-troubleshooting team.
Professor Jocelyn Peabody (Dan Dare) - The scientific brains behind many of the team's most inventive ideas.
The Baltimore Gun Club in From the Earth to the Moon - Three of its wealthy members, Victor Barbicane, Stuyvesant Nicholl, and Ben Sharpe, build a giant gun which launches an occupied capsule to the Moon.
Global Dynamics (Eureka) - A major research facility in the town of Eureka, where most of America's top-secret government experiments are conducted.
The K-science team: Hong Kong Shatterdome (Newton Geiszler and Hermann Gottlieb) - Heads of the kaiju science research team (Pacific Rim)
The Kihara family of mad scientists in A Certain Magical Index, who are dedicated to the pursuit of science, regardless of the cost and often serve as antagonists.
The Lone Gunmen - A group of ardent conspiracy theorists and computer hackers who often assist Mulder and Scully, though sometimes have their own adventures
The Speedwagon Foundation - A group consisting of doctors and archaeologists founded by Robert E. O. Speedwagon somewhere between the story arcs of Phantom Blood and Battle Tendency in JoJo's Bizarre Adventure, who are extremely knowledgeable on Stands, Pillar Men and Dio.
Unorthodox Engineers - A misfit bunch of engineers who solve problems of alien technology/weird planets in the future.
^Peterson, Matthew (September 14, 2012). "REVIEW: Legion Lost #0". Major Spoilers. Archived from the original on September 17, 2012. Retrieved October 18, 2024.
