HBQ1

HBQ1
Identifiers
AliasesHBQ1, HBQ, hemoglobin subunit theta 1
External IDsOMIM: 142240; MGI: 3613460; HomoloGene: 3895; GeneCards: HBQ1; OMA:HBQ1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3049

544763

Ensembl

ENSG00000086506

ENSMUSG00000073063

UniProt

P09105

Q3U0A6

RefSeq (mRNA)

NM_005331

NM_001033981

RefSeq (protein)

NP_005322

NP_001029153

Location (UCSC)Chr 16: 0.18 – 0.18 MbChr 11: 32.24 – 32.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.[5][6]

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000086506 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073063 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  6. ^ a b "Entrez Gene: HBQ1 hemoglobin, theta 1".

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