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HBZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JEB, 3W4U
Identifiers
Aliases	HBZ, HBZ-T1, HBZ1, hemoglobin subunit zeta, HBAZ
External IDs	OMIM: 142310; MGI: 96019; HomoloGene: 110705; GeneCards: HBZ; OMA:HBZ - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	154,503 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	32,228,116 bp
RNA expression pattern
	Top expressed in
	testicle; ; left testis; ; right testis; ; blood; ; ganglionic eminence; ; bone marrow; ; subcutaneous adipose tissue; ; anterior cingulate cortex; ; Amygdala; ; ectocervix;
	Top expressed in
	yolk sac; ; tail of embryo; ; genital tubercle; ; abdominal wall; ; maxillary prominence; ; internal carotid artery; ; mandibular prominence; ; external carotid artery; ; hand; ; somite;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; protein binding; heme binding; metal ion binding; oxygen carrier activity; peroxidase activity; haptoglobin binding; organic acid binding;
Cellular component	hemoglobin complex; extracellular exosome; haptoglobin-hemoglobin complex;
Biological process	oxygen transport; negative regulation of transcription by RNA polymerase II; erythrocyte maturation; transport; hydrogen peroxide catabolic process; protein heterooligomerization; cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	3050
	15126
	ENSG00000130656
	ENSMUSG00000055609
	P02008
	P06467
	NM_005332
	NM_010405
	NP_005323
	NP_034535
	Wikidata
View/Edit Human	View/Edit Mouse

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.^[5]^[6]

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130656 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055609 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (April 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
^ ^a ^b "Entrez Gene: HBZ hemoglobin, zeta".

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Orkin SH, Michelson A (July 1980). "Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia". Nature. 286 (5772): 538–40. Bibcode:1980Natur.286..538O. doi:10.1038/286538a0. PMID 7402334. S2CID 4251647.
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Luo HY, Liang XL, Frye C, Wonio M, Hankins GD, Chui DH, Alter BP (July 1999). "Embryonic hemoglobins are expressed in definitive cells". Blood. 94 (1): 359–61. doi:10.1182/blood.V94.1.359.413a29_359_361. PMID 10381533.
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