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Dr. Guru Prakash Dutta
Dr. Guru Prakash Dutta
Born	19 November 1933; India
Died	25 April 2021 (aged 87)
Nationality	Indian
Alma mater	Punjab University
Known for	Experimental Protozoology; Immunology;
Awards	1976 Shanti Swarup Bhatnagar Prize
	Scientific career
Fields	Cell biology
Institutions	Punjab University; Central Drug Research Institute;

Guru Prakash Dutta (19 November 1933 - 25 April 2021) was an Indian cell biologist and immunologist, known for his contributions to the subjects of Experimental protozoology and Immunology.^[1]^[2] His researches are reported to have assisted in the development of a number of anti-malarial drugs.^[3] He was an elected fellow of the Indian National Science Academy, National Academy of Sciences, India and Indian Society of Parasitology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1976, for his contributions to biological sciences.^[4]

Biography

Guru Prakash Dutta, after graduating in zoology in 1952 from DAV College, Jallandhar^[5] of Punjab University, followed it up with an honors degree in 1955, a master's degree (MSc) in 1956 and a doctoral degree (PhD) in 1961 from the same institution.^[3] He started his career as a lecturer at his alma mater in 1962 where he stayed till his move to Central Drug Research Institute (CDRI) in 1964; in between, he had a stint at National Institutes of Health, Bethesda as a post-doctoral fellow during 1962–63. He served CDRI for more than three decades and was a director's grade scientist at the time of his superannuation in 1993. Post his retirement, he served as an emeritus scientist of the Council of Scientific and Industrial Research at CDRI from 1994 to 1998 and as an honorary consultant on Malaria at the Central Institute of Medicinal and Aromatic Plants from 1998 to 2000.^[3]

Dutta, whose researches on experimental protozoology assisted in a wider understanding of protozoa and its functional morphology, is known to have developed new techniques for the culture of those unicellular eukaryotic organisms and studied their metabolic and growth responses to physico-chemical factors, with special emphasis on Entamoeba histolytica, an anaerobic parasite which causes amoebiasis.^[6] His work on the antimalarial drugs helped in the development of several fast-acting drugs and alpha/beta arteether, alpha and beta arteether, alpha and beta artelinate, dihydroartemisinin, pyronaridine, bulaquine and Tefenoquine are some of drugs developed with the assistance of his researches.^[3]^{[note 1]}

Dutta's researches have been detailed in over 275 articles^[7]^[8] and two books, Antimalarial Drug Development and Prophylaxis against Malaria and Experimental and Clinical Studies on Amoebiasis.^[9] The International Review of Cytology of Academic Press has published five reviews, three on Cytochemistry and ultrastructure of Protozoa and two on Amoebiasis and ResearchGate, an online repository of scientific articles, has listed 130 of his papers.^[10] He has been a collaborator for Walter Reed Army Institute of Research in two of their international programs on Malaria which ran between 1983 and 1994. He has also mentored 40 master's and doctoral scholars in their researches.^[3]

Dutta received the degree of Doctor of Science from the Punjab University in 1973 and the Council of Scientific and Industrial Research awarded him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, for his contributions to biological sciences in 1976.^[2] The Indian National Science Academy elected him as their fellow in 1984 and the National Academy of Sciences, India followed INSA with their fellowship in 1991.^[11] He was also elected by the Indian Society for Parasitology as a fellow in 1993.^[12]

Notes

^ It is reported that 30 patents have been granted for drugs based on Dutta's researches.^[3]

References

^ Tripathi, Renu (2021). "Obituary". Journal of Parasitic Diseases. 45 (2). Springer Link: 581. doi:10.1007/s12639-021-01406-w. PMC 8254685. S2CID 220217533.
^ ^a ^b "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 19 September 2016.
^ ^a ^b ^c ^d ^e ^f "Indian Fellow - G. P. Dutta". Indian National Science Academy. 2016. Retrieved 21 September 2016.
^ "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 19 September 2016.
^ G. P. Dutta (September 1959). "Histochemical Studies of Herpetomonas muscarum" (PDF). Journal of Microscopical Science. 100 (3): 413–419.
^ "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 36. Archived from the original (PDF) on 4 March 2016. Retrieved 19 September 2016.
^ R. A. Vishwakarma; R. Mehrotra; R. Tripathi; G. P. Dutta (1992). "Stereoselective Synthesis and Antimalarial Activity of α-Artelinic Acid from Artemisinin". J. Nat. Prod. 55 (8): 1142–1144. doi:10.1021/np50086a018. PMID 1431937.
^ Renu Tripathi; Charles W Jefford; G P Dutta (August 2006). "Blood schizontocidal activity of selected 1,2,4-trioxanes (Fenozans) against the multidrug-resistant strain of Plasmodium yoelii nigeriensis (MDR) in vivo". Parasitology. 133 (1): 1–9. doi:10.1017/s0031182006009905. PMID 16764736. S2CID 25528368.
^ G. P. Dutta (1982). Experimental and Clinical Studies on Amoebiasis. Tata-McGraw Hill. p. 390. ISBN 978-0070963955.
^ "G P Dutta on ResearchGate". Author search. 2016. Retrieved 21 September 2016.
^ "NASI fellows". National Academy of Sciences, India. 2016. Archived from the original on 17 July 2015. Retrieved 22 September 2016.
^ "Fellows - ISP". Indian Society for Parasitology. 2016. Archived from the original on 13 December 2014. Retrieved 21 September 2016.