Swarup, while working with Stanley Cohen in the US on cellular signaling mechanisms, is reported to have discovered a new nuclear protein tyrosine phosphatase (PTPase) and his subsequent work demonstrated that the protein plays a part in the regulation of cell proliferation.[9] Later, during his early days at CCMB, he elucidated the molecular cloning of a protein tyrosine phosphatase and its bind with DNA and established the methodology for alternative splicing of a gene to form four different variations of PTPase.[4] Swarup's studies are known to have assisted in identifying the first cargo (PTP-S4/TC48) for the putative cargo receptors in mammalian cells. He has established a laboratory, Ghanshyam Swarup Group, where his team focuses on researches on protein optineurin and how disease-associated mutation affect humans.[8] Associated with L. V. Prasad Eye Institute, he works on one of the mutated genes of optineurin as a causative factor of glaucoma, an eye disease leading to irrecoverable loss of vision[10] and has elaborated on the pathogenesis in the disease from a molecular perspective.[11]
Swarup has published several articles detailing his research findings;[note 1]ResearchGate, an online repository of scientific articles has listed 81 of them.[12] He is a member of the editorial board of the Journal of Molecular Signaling[13] and is known to be active in the researches done by others.[14] Swarup has mentored several scholars in their doctoral and post-doctoral researches at his research group in CCMB[1] as well as scholars from other institutions.[15]
