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Gambsheim lies adjacent to a river-crossing into Germany that is favoured by southbound traffic on the A35 autoroute wishing to avoid traffic delays around Strasbourg. The crossing coincides with the location of a large river lock which is also the site of one of the Rhine's first fish ladders. The latter was installed to support migratory fish in general and, more specifically, in an attempt to restore the abundant salmon population for which the upper Rhine was famous before the early 20th century, when the installation of a series of locks rendered the river navigable beyond Basel for boats, but blocked it for migrating fish.