FKBPL

FKBPL
Identifiers
Aliases	FKBPL, DIR1, NG7, WISP39, FKBP4, FK506 binding protein like, FKBP prolyl isomerase like
External IDs	OMIM: 617076; MGI: 1932127; HomoloGene: 10529; GeneCards: FKBPL; OMA:FKBPL - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,130,288 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,865,298 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; skin of leg; ; granulocyte; ; skin of abdomen; ; mucosa of transverse colon; ; islet of Langerhans; ; apex of heart; ; body of stomach; ; blood;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; primary oocyte; ; granulocyte; ; muscle of thigh; ; embryo; ; right kidney; ; secondary oocyte; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; extracellular region;
Biological process	response to radiation; protein stabilization; regulation of angiogenesis; regulation of blood vessel branching;
	Sources:Amigo / QuickGO
Orthologs
	63943
	56299
	ENSG00000204315; ENSG00000230907; ENSG00000224200; ENSG00000223666
	ENSMUSG00000033739
	Q9UIM3
	O35450
	NM_022110
	NM_019873
	NP_071393; NP_071393.2
	NP_063926
	Wikidata
View/Edit Human	View/Edit Mouse

FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.^[5]

Function

FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.^[6]

FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.^[7] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.^[8]

It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.^[9]

FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.^[10]

References

^ ^a ^b ^c ENSG00000230907, ENSG00000224200, ENSG00000223666 GRCh38: Ensembl release 89: ENSG00000204315, ENSG00000230907, ENSG00000224200, ENSG00000223666 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033739 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE (February 1997). "Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line". Biochem. Soc. Trans. 25 (1): 335–42. doi:10.1042/bst0250335. PMID 9056895.
^ "Entrez Gene: FKBPL".
^ Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG (November 1999). "A novel human stress response-related gene with a potential role in induced radioresistance". Radiat. Res. 152 (5): 451–61. Bibcode:1999RadR..152..451R. doi:10.2307/3580140. JSTOR 3580140. PMID 10521921.
^ Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A (January 2005). "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein". Mol. Cell. 17 (2): 237–49. doi:10.1016/j.molcel.2004.11.049. PMID 15664193.
^ McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T (July 2008). "A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling". Endocrinology. 149 (11): 5724–34. doi:10.1210/en.2008-0168. PMID 18669603. S2CID 32563192.
^ McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T (February 2010). "FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy". Cancer Res. 70 (3): 1090–100. doi:10.1158/0008-5472.CAN-09-2515. PMID 20103631.