Protein-coding gene in the species Homo sapiens
Exosome component 7 , also known as EXOSC7 , is a human gene , the protein product of which is part of the exosome complex .[ 5]
Interactions
Exosome component 7 has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000075914 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025785 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: EXOSC7 exosome component 7" .^ a b c Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol . 323 (4): 653– 63. doi :10.1016/s0022-2836(02)00947-6 . hdl :2066/186665 PMID 12419256 . ^ Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol . 315 (4): 809– 18. doi :10.1006/jmbi.2001.5265 . hdl :2066/261980 PMID 11812149 .
Further reading
Butler JS (2002). "The yin and yang of the exosome". Trends Cell Biol . 12 (2): 90– 6. doi :10.1016/S0962-8924(01)02225-5 . PMID 11849973 . Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 2 (1): 37– 43. doi :10.1093/dnares/2.1.37 PMID 7788527 . Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome" . J. Biol. Chem . 276 (9): 6177– 84. doi :10.1074/jbc.M007603200 hdl :2066/186951 PMID 11110791 . Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs" . Cell . 107 (4): 451– 64. doi :10.1016/S0092-8674(01)00578-5 PMID 11719186 . S2CID 14817671 . Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus" . Curr. Biol . 12 (1): 1– 11. Bibcode :2002CBio...12....1A . doi :10.1016/S0960-9822(01)00650-9 PMID 11790298 . S2CID 14132033 . Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol . 315 (4): 809– 18. doi :10.1006/jmbi.2001.5265 . hdl :2066/261980 PMID 11812149 . Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome" . Arthritis Res . 4 (2): 134– 8. doi :10.1186/ar389 PMC 83843 PMID 11879549 . Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol . 323 (4): 653– 63. doi :10.1016/S0022-2836(02)00947-6 . hdl :2066/186665 PMID 12419256 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation" . Genome Res . 14 (7): 1315– 23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77– 83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
PDB gallery
2nn6 : Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40
