Exosome component 6

EXOSC6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC6, EAP4, MTR3, Mtr3p, hMtr3p, p11, Exosome component 6
External IDs	OMIM: 606490; MGI: 1919794; HomoloGene: 12469; GeneCards: EXOSC6; OMA:EXOSC6 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	70,251,940 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	111,784,296 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; endothelial cell; ; Brodmann area 23; ; postcentral gyrus; ; Brodmann area 46; ; primary visual cortex; ; superior frontal gyrus; ; middle temporal gyrus; ; Achilles tendon; ; entorhinal cortex;
	Top expressed in
	embryo; ; embryo; ; blastocyst; ; morula; ; vasculature; ; vasculature of organ; ; temporal lobe; ; amygdala; ; spinal cord; ; brain stem;
	More reference expression data
	n/a
Gene ontology
Molecular function	exoribonuclease activity; RNA binding;
Cellular component	cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); cytoplasmic exosome (RNase complex); nucleolus; nucleus; nucleoplasm;
Biological process	regulation of mRNA stability; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; rRNA 3'-end processing; rRNA catabolic process; DNA deamination; nuclear mRNA surveillance; exonucleolytic catabolism of deadenylated mRNA; U4 snRNA 3'-end processing; polyadenylation-dependent snoRNA 3'-end processing; rRNA processing; positive regulation of isotype switching; isotype switching; RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	118460
	72544
	ENSG00000223496
	ENSMUSG00000109941
	Q5RKV6
	Q8BTW3
	NM_058219
	NM_028274
	NP_478126
	NP_082550
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene.^[5]^[6]^[7]

This gene product constitutes one of the subunits of the multisubunit particle called the exosome complex, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.^[7]

Interactions

Exosome component 6 has been shown to interact with Exosome component 7,^[6]Exosome component 8^[6] and Exosome component 1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000223496 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000109941 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
^ ^a ^b ^c ^d Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J Mol Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. hdl:2066/186665. PMID 12419256.
^ ^a ^b "Entrez Gene: EXOSC6 exosome component 6".