Diacetyl reductase ((R)-acetoin forming)

Diacetyl reductase, (R)-acetoin forming
Identifiers
EC no.1.1.1.303
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Diacetyl reductase ((R)-acetoin forming) (EC 1.1.1.303, (R)-acetoin dehydrogenase) is an enzyme with systematic name (R)-acetoin:NAD+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(R)-acetoin + NAD+ diacetyl + NADH + H+

The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the yeast Saccharomyces cerevisiae. This enzyme is different from EC 1.1.1.304, diacetyl reductase ((S)-acetoin forming).

References

  1. ^ Heidlas J, Tressl R (1990). "Purification and characterization of a (R)-2,3-butanediol dehydrogenase from Saccharomyces cerevisiae". Archives of Microbiology. 154 (3): 267–73. doi:10.1007/bf00248966. PMID 2222122. S2CID 21979677.
  2. ^ González E, Fernández MR, Larroy C, Solà L, Pericàs MA, Parés X, Biosca JA (November 2000). "Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene". The Journal of Biological Chemistry. 275 (46): 35876–85. doi:10.1074/jbc.M003035200. PMID 10938079.


Stub icon

This enzyme-related article is a stub. You can help Wikipedia by expanding it.