D-arabinitol 2-dehydrogenase

D-arabinitol 2-dehydrogenase
Identifiers
EC no.1.1.1.250
CAS no.336883-93-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a D-arabinitol 2-dehydrogenase (EC 1.1.1.250) is an enzyme that catalyzes the chemical reaction

D-arabinitol + NAD+ ⇌ D-ribulose + NADH + H+

Thus, the two substrates of this enzyme are D-arabinitol and NAD+, whereas its 3 products are D-ribulose, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming). This enzyme is also called D-arabinitol 2-dehydrogenase (ribulose-forming).

References

  • Wong B, Murray JS, Castellanos M, Croen KD (1993). "D-arabitol metabolism in Candida albicans: studies of the biosynthetic pathway and the gene that encodes NAD-dependent D-arabitol dehydrogenase". J. Bacteriol. 175 (19): 6314–20. doi:10.1128/jb.175.19.6314-6320.1993. PMC 206728. PMID 8407803.
  • Quong MW, Miyada CG, Switchenko AC, Goodman TC (1993). "Identification, purification, and characterization of a D-arabinitol-specific dehydrogenase from Candida tropicalis". Biochem. Biophys. Res. Commun. 196 (3): 1323–9. doi:10.1006/bbrc.1993.2397. PMID 8250887.


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