PROFILPELAJAR.COM

CPA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AYE, 1DTD, 1O6X
Identifiers
Aliases	CPA2, carboxypeptidase A2
External IDs	OMIM: 600688; MGI: 3617840; HomoloGene: 37541; GeneCards: CPA2; OMA:CPA2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	130,289,798 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,564,475 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; pancreatic epithelial cell; ; body of stomach; ; beta cell; ; duodenum; ; testicle; ; C1 segment; ; fundus; ; jejunal mucosa;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; embryo; ; duodenum; ; retinal pigment epithelium; ; genital tubercle; ; saccule; ; sexually immature organism; ; migratory enteric neural crest cell; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxypeptidase activity; metallopeptidase activity; zinc ion binding; peptidase activity; hydrolase activity; metallocarboxypeptidase activity; metal ion binding;
Cellular component	extracellular region; vacuole; extracellular space;
Biological process	proteolysis; protein catabolic process in the vacuole;
	Sources:Amigo / QuickGO
Orthologs
	1358
	232680
	ENSG00000158516
	ENSMUSG00000071553
	P48052
	Q504N0
	NM_001869
	NM_001024698
	NP_001860
	NP_001019869
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene.^[5]^[6]^[7]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158516 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071553 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Catasus L, Vendrell J, Aviles FX, Carreira S, Puigserver A, Billeter M (Apr 1995). "The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model". J Biol Chem. 270 (12): 6651–7. doi:10.1074/jbc.270.12.6651. PMID 7896805.
^ Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
^ ^a ^b "Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)".

External links

The MEROPS online database for peptidases and their inhibitors: M14.002
Overview of all the structural information available in the PDB for UniProt: P48052 (Human Carboxypeptidase A2) at the PDBe-KB.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158516 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071553 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7896805-5] Catasus L, Vendrell J, Aviles FX, Carreira S, Puigserver A, Billeter M (Apr 1995). "The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model". J Biol Chem. 270 (12): 6651–7. doi:10.1074/jbc.270.12.6651. PMID 7896805.

[pmid10860668-6] Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.

[entrez-7] "Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Carboxypeptidase A2

References

Further reading

External links