ALC-0159

ALC-0159
Names
Other names
2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C33H67NO3/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-34(33(35)32-37-31-30-36-3)29-27-25-23-21-19-17-15-13-11-9-7-5-2/h4-32H2,1-3H3
    Key: BPWFJNQUTKVHIR-UHFFFAOYSA-N
  • CCCCCCCCCCCCCCN(CCCCCCCCCCCCCC)C(=O)COCCOC
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine (0.05 mg per dose)[1] that contains the active ingredient tozinameran.[2]

See also

Pfizer–BioNTech COVID-19 vaccine nanoparticle ingredients
Others

References

  1. ^ Schoenmaker, Linde; Witzigmann, Dominik; Kulkarni, Jayesh A.; Verbeke, Rein; Kersten, Gideon; Jiskoot, Wim; Crommelin, Daan J. A. (2021-05-15). "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability". International Journal of Pharmaceutics. 601: 120586. doi:10.1016/j.ijpharm.2021.120586. ISSN 0378-5173. PMC 8032477. PMID 33839230.
  2. ^ "Public Assessment Report Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (BNT162b2 RNA) concentrate for solution for injection" (PDF). Regulation 174. MHRA. 15 December 2020.


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