The company has developed an mRNA-based human therapeutic for intravenous administration to bring individualized mRNA-based cancer immunotherapy to clinical trials and to establish its own manufacturing process.[3]
In 2020, BioNTech, partnering with Pfizer for testing and logistics, developed the RNA vaccineBNT162b2 for preventing COVID-19 infections, which at the time offered a 91% efficacy[4] in preventing confirmed COVID-19 occurring at least 7 days after the second dose of vaccine.[5] On 2 December 2020, temporary HMR authorization was granted by the United Kingdom government for BNT162b2 vaccinations within the United Kingdom.[6][7] It was the first mRNA vaccine ever authorized. Some days later the vaccine also received an emergency approval in the United States,[8]Canada[9] and Switzerland.[10] On 21 December 2020, the European Commission approved BioNTech/Pfizer's coronavirus vaccine in accordance with the positive recommendation of the European Medicines Agency (EMA).[11] In August 2021, thanks to a meteoric rise in its share price, BioNTech’s market capitalization briefly exceeded US$100 billion, making it among the most valuable companies in Germany.[12]
Between 2014 and 2018, many research results on mRNA mechanisms were published by BioNTech.[22]Collaborations and commercialization programs were concluded with various companies and scientific institutions starting in 2015.[23] During this period, BioNTech filed several patent applications and developed a multi-layered strategy to protect its intellectual property in the various technology platforms and their application in the treatment of cancer and other serious diseases.[citation needed]
In August 2018, the company entered into a multi-year research and development (R&D) collaboration with the US company Pfizer, Inc. to develop mRNA-based vaccines for prevention of influenza. Under the terms of the agreement, following BioNTech's completion of a first-in-human clinical study, Pfizer would assume sole responsibility for further clinical development and commercialization of mRNA-based flu vaccines.[24]
In January 2019, Sanofi invested €80 million in BioNTech and extended the mRNA cancer research collaboration between the two companies; Sanofi previously paid US$60 million upfront for the rights to five discovery-stage immunotherapies of BioNTech in 2015.[25] In July 2019, Fidelity Management & Research Company led a Series B investment round totalling $325 million, with additional investments from Redmile Group, Invus, Mirae Asset Financial Group, Platinum Asset Management, Jebsen Capital, Steam Athena Capital, BioVeda China Fund and the Struengmann Family Office.[26][27] In September 2019, BioNTech received a capital contribution of US$55 million from the Bill & Melinda Gates Foundation, with the option of doubling that investment amount at a later date.[28]
Nasdaq IPO (2019) to COVID-19
Since 10 October 2019, BioNTech, with its newly founded North American headquarters in Cambridge, Massachusetts, has been publicly traded as American Depository Shares (ADS) on the NASDAQ Global Select Market under the ticker symbol, BNTX.[29] BioNTech was able to generate total gross proceeds of 150 million dollars from the IPO.[30]
In 2021, BioNTech announced it would open its Asia headquarters in Singapore, and also open a vaccine manufacturing plant there, with support from the Singapore Economic Development Board.[31] The Singapore factory is expected to be operational by 2023 and produce hundreds of millions of doses of mRNA vaccines per year.[32] A collaboration with Fosun Pharma is planned to add a facility in China to produce a billion doses per year for China, Macau, Hong Kong, and Taiwan, though as of August 2021, the PRC had not approved any foreign-developed COVID-19 vaccines.[32] In July 2023, BioNTech acquired the British startup Instadeep for £562million ($682million) in order to expand its activities in the area of artificial intelligence for drug discovery, design and development.[33][34]
Locations of BioNTech in Germany. The other two are in the United States.
BioNTech's founding place and global headquarters is Mainz, Germany, where the COVID-19 vaccine was created. The company runs multiple sites in the country.
Further research locations are in San Diego and Cambridge, Massachusetts, the latter of which also serves as the North American headquarters.
Additionally the company owns GMP-certified production facilities in Idar-Oberstein, Martinsried, Neuried, Bavaria, and Berlin. In November 2020, the company acquired facilities from Novartis in Marburg to ramp up its vaccine production.[35][36]
The EIB then signed a €100 million loan in June 2020, after an accelerated approval (two months for a process that usually takes more than a year). This financing helped BioNTech's vaccine trials and manufacturing. The EIB loan is part of the InnovFin Corporate Research Equity programme and the European Fund for Strategic Investments. This programme supports "innovative and higher-risk projects" backed by the European Investment Bank with a guarantee from the European Union budget.[38][39][40][41] On 17 March 2020, BioNTech received a $135 million investment from Fosun Pharma in exchange for 1.58 million shares in BioNTech and the future development and marketing rights of the mRNA vaccine BNT162b2 in China.[42] In June 2020, BioNTech received €250 million from Temasek Holdings (Singapore) via the purchase of ordinary shares and 4 years convertible notes, but also from other investors through a private placement of mandatory convertible bonds.[43] On 15 September 2020, the German Federal Ministry of Education and Research (BMBF) awarded a €375 million grant to BioNTech, to accelerate the development of the COVID-19 vaccine.[44]
Board
Board of BioNTech, as of March 2024, is made up of Uğur Şahin CEO, Jens Holstein CFO, Sean Marett Chief Business and Commercial Officer, Sierk Poetting COO, Ryan Richardson Chief Strategy Officer, James Ryan Chief Legal Officer, Özlem Türeci Chief Medical Officer.
"Project Lightspeed", the project to develop a novel mRNA technology for a COVID-19 vaccine, began in mid-January 2020 just days after the SARS-Cov-2genetic sequence was first made public.[45] The company is partnered on this project with Pfizer[46] and Fosun.[47][48]
The production of the vaccine was followed by clinical trials, the success of which was a prerequisite for the commencement of marketing. On 9 November 2020, BioNTech and Pfizer announced that 43,500 people in 6 countries had received a test vaccine against COVID-19 with more than 90 percent effectiveness. On the basis of successful testing, they asked for the right to distribute vaccines in the United States, as well as in the European Union, the United Kingdom and Japan.[49]
Vaccine distribution timeline
In July 2020, BioNTech and pharmaceutical corporation Pfizer signed contracts to supply 120 million doses for Japan, 100 million doses for the United States at $19.50, and 40 million doses for the United Kingdom, if proven effective, safe, and licensed.[50][51][52][53] On 5 August 2020, Canada pre-ordered 20 million doses of the vaccine.[54] In September 2020, Germany privately ordered 30 million doses, outside the collective EU purchasing scheme.[55] On 5 November 2020, Australia pre-ordered 10 million doses.[56] On 9 November 2020, BioNTech-Pfizer released a positive interim analysis of a Phase III clinical trial in the United States. On 10 November 2020, BioNTech and Pfizer applied for an emergency use authorization (EUA) with the FDA, which was reviewed by mid-December.[57][58] The FDA released a document explaining that an EUA is "a mechanism to facilitate the availability and use of medical countermeasures, including vaccines, during public health emergencies, such as the current COVID-19 pandemic."[59] On 11 November 2020, the European Union pre-ordered 300 million doses, at an initial price of €12 per dose. Under the agreement, the vaccine-producing pair, BioNTech and Pfizer are subject to a tightened legal obligation to bring all the experience they have gained to the EMA for review.[60][61]Belgium's budget state secretary Eva De Bleeker [nl] accidentally revealed the vaccine purchase price-per-dose agreed by the EU with various companies, with Oxford-AstraZeneca at €1.78; Johnson & Johnson at $8.50, Sanofi-GSK at €7.56, CureVac at €10, and Moderna at $18.[62] In the same month, Israel ordered 8 million doses at $23.50 a dose.[63][64] In the same month BioNTech-Pfizer submitted an EUA application in Canada.[65] On 2 December 2020, the United Kingdom granted conditional temporary authorization (under Regulation 174 of the Human Medicines Regulations 2012) for BNT162b2,[6] becoming the first country to approve an mRNA vaccine and the first Western country to approve a COVID-19 vaccine for national use.[7][66] In the same month, BNT162b2 was revealed to also be under evaluation for EUA status in several other countries.[67] On 15 December 2020, Fosun Pharma agreed a deal to deliver 100 million doses of the BioNTech-Pfizer vaccine to China,[68] with Hong Kong securing 7.5 million doses. On 21 December 2020, the European Medicines Agency (EMA) authorised a one-year conditional use of the BioNTech-Pfizer vaccine in the European Union. Emer Cooke, Director of the EMA, stated that the benefits of the vaccine far outweigh the potential risks.[69] On 26 December 2020, following the authorisation, initial mass vaccination against coronavirus commenced in Hungary and Slovakia.[70]
In early 2023 BioNTech started a series of clinical trials in the United Kingdom for mRNA based immunotherapies targeting several types of cancer.[74] In November 2023, in an interview to German broadcaster ZDF, BioNTech CEO Uğur Şahin said the company expects a mRNA-based therapeutic cancer vaccine approval by 2030.[75]
Sponsorship
BioNTech, together with Pfizer, co-sponsored the Academy Awards ceremony in March 2022 as main sponsors.[76]
In the sponsorship, the pharmaceutical duo stated that the widespread use of their vaccines and booster shots has helped prevent Covid19 diseases and protect lives, and the film industry has partnered to promote vaccines, mask use and other prevention strategies. BioNTech's spectacular marketing promotional success in the 2022 Oscars' sponsorship was its ability to appear ahead of its huge pharma partner Pfizer in the promotional duo's ubiquitous roster. This was a significant achievement because by this time 'BioNTech' had been removed from the name of the vaccine in almost every language in the world, and their joint product was mostly referred to simply as 'Pfizer'.[77]
Jalan JaksaGenre Drama Komedi PembuatTripar Multivision PlusPengembang Kishur Ken Abimael Ditulis oleh Ery Setyawan Cuk FK SkenarioZulki ZakariaCeritaRenaldiSutradara Cuk FK Ery Setyawan Pengarah kreatifRaakhee PunjabiPemeran Nova Eliza Indra L Bruggman Rheina Maryana Cici Tegal Stefanie Hariadi Risdo Alaro Gracia Indri Five Vi Fanny Syam Opie Kumis Agus Kuncoro Gisela Cindy Shandy Sjariff Lagu pembukaJalan Jaksa, Didi AGPLagu penutupJalan Jaksa, Didi AGPPenata musikDidi AGPNegara asalI...
Questa voce o sezione sull'argomento Emirati Arabi Uniti non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. Abu Dhabiemiratoأبوظبي Abu Dhabi – VedutaPanorama di Abu Dhabi LocalizzazioneStato Emirati Arabi Uniti AmministrazioneCapoluogoAbu Dhabi EmiroSceicco Mohammed bin Zayed Al Nahyan TerritorioCoordinatedel capoluogo24°28′00.12″N 54°22�...
هذه المقالة بحاجة لصندوق معلومات. فضلًا ساعد في تحسين هذه المقالة بإضافة صندوق معلومات مخصص إليها. يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (ديسمبر 2019) سنوات ...
Sid JordanCuplikan Jordan (kanan) dengan Tom Mix dalam The Coming of the Law (1919)Lahir(1889-08-12)12 Agustus 1889Muskogee, Oklahoma, Amerika SerikatMeninggal30 September 1970(1970-09-30) (umur 81)Hemet, California, Amerika SerikatPekerjaanPemeranTahun aktif1913-1944 Sid Jordan (12 Agustus 1889 – 30 September 1970) adalah seorang pemeran film asal Amerika Serikat. Ia tampil dalam 130 film antara 1913 dan 1944. Filmografi pilihan The Man from Texas (1915) The Golden ...
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: The Wanda Sykes Show – news · newspapers · books · scholar · JSTOR (July 2018) (Learn how and when to remove this template message) American TV series or program The Wanda Sykes ShowCreated byWanda SykesPresented byWanda SykesStarringWanda SykesKeith Robin...
Rébellion de l'Escambray Informations générales Date 1959 - 1965 Lieu Cuba Issue Victoire castriste Belligérants Gouvernement castriste Rebelles anti-castristes Commandants Fidel CastroChe GuevaraManuel Fajardo Rivero † Osvaldo RamírezPlinio PrietoEdel Montiel Forces en présence 70 000 Plusieurs milliers Pertes Plusieurs centaines 3 591 Données clés modifier La rébellion de l'Escambray est une rébellion cubaine qui a duré six ans, entre 1959 et 1965, principalement dans...
Commune in southwestern France Commune in Nouvelle-Aquitaine, FranceBassillon-VauzéCommuneThe Entrance to the communeLocation of Bassillon-Vauzé Bassillon-VauzéShow map of FranceBassillon-VauzéShow map of Nouvelle-AquitaineCoordinates: 43°27′27″N 0°04′27″W / 43.4575°N 0.0742°W / 43.4575; -0.0742CountryFranceRegionNouvelle-AquitaineDepartmentPyrénées-AtlantiquesArrondissementPauCantonTerres des Luys et Coteaux du Vic-BilhIntercommunalityNord Est Béarn...
Kirko Bangz discographyEPs2Singles9Mixtapes11Featured singles4Guest appearances30 This is the discography of Kirko Bangz, an American rapper, singer and record producer. Albums Extended plays List of extended plays and selected albums details Title Album details Fallin' Up Mix Released: August 31, 2015 Label: Self-released Formats: digital download Playa Made Released: February 19, 2016 Label: LMG Music Group Formats: digital download Mixtapes List of mixtapes and selected album details Title...
Capital Development AuthorityRajdhani Unnayan Kartripakkha (RAJUK)RAJUKAgency overviewFormed30 April 1987Preceding agencyDhaka Improvement Trust (DIT),1956Superseding agencyDevelopment of DhakaHeadquartersRAJUK Bhaban, Rajuk Avenue, Motijheel, Dhaka-1000Minister responsible(etc.)Agency executiveAnisur Rahman Miah, ChairmanParent agencyGovernment of BangladeshWebsitewww.rajuk.gov.bd RAJUK Bhaban Rajdhani Unnayan Kartripakkha (abbreviated as RAJUK; literally the Capital Development Authority) i...
Niger–Congo language of Sudan ShwaiShirumbaNative toSudanRegionNuba HillsEthnicityShwaiNative speakers(3,500 cited 1989)[1]Language familyNiger–Congo? Atlantic–CongoTalodi–HeibanHeibanShwaiLanguage codesISO 639-3shwGlottologshwa1239ELPShwaiShwai is classified as Critically Endangered by the UNESCO Atlas of the World's Languages in Danger Shwai (Shuway) is a Niger–Congo language in the Heiban family spoken in Kordofan, Sudan. It is also called Ludumor. Dialects are Shabu...
American actress (born 1988) Maiara WalshWalsh in 2010Born (1988-02-18) February 18, 1988 (age 35)Seattle, Washington, U.S.OccupationActressYears active2005–present Maiara Walsh (/maɪˈɑːdə/; Brazilian Portuguese: [majˈaɾɐ]; born February 18, 1988[1]) is an American-Brazilian actress. She played Ana Solis on the sixth season of the ABC show Desperate Housewives, Meena Paroom on the Disney Channel sitcom Cory in the House and Simone Sinclair on the Freeform s...
يُشار إلى المكمّل المعدني المعجزة غالبًا باسم المحلول المعدني المعجزة أو الأسطورة أو إم إم إس أو بروتوكول سي دي، هو ثاني أكسيد الكلور، مبيضٌ صناعي. يُصنع عن طريق مزج محلول كلوريت الصوديوم مع حمض (مثل عصائر الحمضيات). ينتِج هذا الخليط ثاني أكسيد الكلور، مادة كيميائية سامة يم...
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Family of mammals This article is about the ruminant animal. For other uses, see Deer (disambiguation). Fawn and Stag redirect here. For other uses, see Fawn (disambiguation) and Stag (disambiguation). Deer[1]Temporal range: Early Miocene–Recent PreꞒ Ꞓ O S D C P T J K Pg N Images of a few members of the family Cervidae (counterclockwise from top left): the red deer (Cervus elaphus), white-tailed deer (Odocoileus virginianus), gray brocket (Mazama gouazoubira), wapiti (Cervus can...
1949 aviation accident This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (August 2020) (Learn how and when to remove this template message) Hurum air disasterThe aircraft involved in the crash pictured on 2 April 1948AccidentDate20 November 1949SummaryCFIT, as heavy fog obscured a mountain in the airplane's pathSiteHurum, Norway59°37′12″N 10°34′21″E&#x...
DAC-in-the-Box, an external digital-to-analog converter intended to improve the sound of the user's CD player Audio Alchemy was a high end audio equipment manufacturer based in California, USA. The company was first formed in the late 1980s, producing many lines of relatively affordable audio products, including CD players, transports, digital audio processors, and amplifiers. It went out of business in the late 1990s, was briefly relaunched in the early 2000s as Alchemy2, then was relaunched...
LeerdammerNama lainMaasdammerNegara asalBelandaSumber susuSapiDipasteurisasiYaTeksturKerasKadar lemak45%Waktu pematangan5 mingguSertifikasiTidak[1] Leerdammer adalah salah satu versi keju Maasdam dari Belanda yang diproduksi dengan menggunakan susu sapi yang dipasteurisasi.[1][2] Selain Leerdammer, keju Maasdam juga dijual dengan merek lain seperti Ronduer, Goyweter, dan Fricotal.[2] Keju Leerdammer diproduksi di daerah provinsi Utrecht.[2] Keju ini mem...
Unreferenced BLPs Hello Mcflytrap! Thank you for your contributions. I am a bot alerting you that 1 of the articles that you created is tagged as an Unreferenced Biography of a Living Person. The biographies of living persons policy requires that all personal or potentially controversial information be sourced. In addition, to ensure verifiability, all biographies should be based on reliable sources. If you were to bring this article up to standards, it would greatly help us with the current...
Barbro Maria TillerFødt1953FarLars TillerNasjonalitetNorgeBarbro Maria Tiller på Commons Barbro Maria Tiller - «Tre hus 2», silketrykk, serigrafi 2004 32 x 26 cm Barbro Maria Tiller - «Youyu», papir og akryl på plate 2008, 33 x 74 cm Barbro Maria Tiller (født 27. juli 1953 i Trondheim) er en norsk billedkunstner. Hun bor og arbeider i fødebyen, og har atelier ved Lademoen Kunstnerverksteder. Hun er utdannet ved Kunstakademiet i Trondheim (1974–1978). Hun arbeider med maleri, collag...
