119
11519
ENSG00000075340
ENSMUSG00000030000
P35612
Q9QYB8
NM_017484NM_017485NM_017486NM_017487NM_017488
NM_013458
NP_001171983NP_001171984NP_001608NP_059516NP_059522
NP_038486
Beta-adducin is a protein that in humans is encoded by the ADD2 gene.[5][6]
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta, and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.
While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains.
The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3' end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.[6]
ADD2 has been shown to interact with FYN.[7]
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
Korean Nobel laureates and nominees The Nobel Prize medal received by the laureates As of 2023[update], the Nobel Prize has been awarded to 975 people and 27 organizations since it was founded in 1901.[1] As of April 2023[update], only one Korean has become a Nobel laureate: South Korean President Kim Dae-jung. Kim was awarded the 2000 Nobel Peace Prize for his efforts to push for national reconciliation between the divided Koreas during a summit meeting in Pyongyang…
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NHL 2007/08 Liga National Hockey League Zeitraum 29. September 2007 bis 4. Juni 2008 Teams 30 Spiele/Team 82 Draft Austragung NHL Entry Draft 2007 Top-Pick Vereinigte Staaten Patrick Kane Gewählt von Chicago Blackhawks Reguläre Saison Presidents’ Trophy Detroit Red Wings MVP Russland Alexander Owetschkin (Washington) Topscorer Russland Alexander Owetschkin (Washington) Playoffs Stanley-Cup-Sieger Detroit Red Wings Finalist Pittsburgh Penguins Playoff-MVP Schweden Henrik Zetterberg (Detroit) …
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1965 air crash in the United Kingdom Little Baldon air crashA Handley Page Hastings C1A, the same variant as TG577 which crashedAccidentDate6 July 1965SummaryMechanical fault due to metal fatigueSiteLittle Baldon, Oxfordshire, England, United Kingdom 51°40′38.64″N 1°10′51.71″W / 51.6774000°N 1.1810306°W / 51.6774000; -1.1810306AircraftAircraft typeHandley Page HastingsOperatorRoyal Air ForceRegistrationTG577Flight originRAF Abingdon, EnglandDestinationRAF…
Governing body of LDS Church This article is about the Twelve in The Church of Jesus Christ of Latter-day Saints. For wider use in the Latter Day Saint movement, see Quorum of the Twelve. The First Presidency and the Quorum of the Twelve Apostles in September 1898[1] In the Church of Jesus Christ of Latter-day Saints (LDS Church), the Quorum of the Twelve Apostles (also known as the Quorum of the Twelve, the Council of the Twelve Apostles, or simply the Twelve) is one of the governing bo…
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Sport federation International Kendo FederationFormation1970TypeSports organizationHeadquartersTokyo, JapanMembership Unknown.Official language EnglishPresidentMr. Fujio CHOWebsitewww.kendo-fik.org The forms of the Nihon Kendō Kata (日本剣道形) were finalized 1933 based on the Dai nihon Teikoku Kendo Kata, composed in 1912.[1] The International Kendo Federation (FIK) was founded in 1970. It is an international federation of national and regional kendo associations. The FIK is a non…
Protein-coding gene in the species Homo sapiens ING1Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2QICIdentifiersAliasesING1, p24ING1c, p33, p33p33ING1b, p47, p47ING1a, inhibitor of growth family member 1External IDsOMIM: 601566 MGI: 1349481 HomoloGene: 40119 GeneCards: ING1 Gene location (Human)Chr.Chromosome 13 (human)[1]Band13q34Start110,712,736 bp[1]End110,723,339 bp[1]Gene location (Mouse)Chr.Chromosome 8 (mouse)[2]Band8|8 A1.1Sta…
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Bulgarian volleyball player Iliyana PetkovaPersonal informationNationality BulgariaBorn (1977-11-10) 10 November 1977 (age 46)Height1.90 m (6 ft 3 in)Weight72 kg (159 lb)Spike305 cm (120 in)Block298 cm (117 in) Iliana Petkova (born 10 November 1977), was a Bulgarian volleyball player. She participated at the 2002 FIVB Volleyball Women's World Championship in Germany.[1] Career Iliyana Petkova started her volleyball career in Bulgaria…
System of marks added to Hebrew letters You can help expand this article with text translated from the corresponding article in Hebrew. (August 2012) Click [show] for important translation instructions. View a machine-translated version of the Hebrew article. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-tra…
SuperligaNegaraDenmarkKonfederasiUEFADibentuk1991Musim perdana1991Jumlah tim12Tingkat pada piramida1Degradasi keDivisi 1 DenmarkPiala domestikPiala DenmarkPiala internasionalUEFA Champions LeagueUEFA Europa Conference LeagueJuara bertahan ligaKopenhagen (gelar ke- 15) (2022–23)Klub tersuksesKopenhagen (15 gelar)Pencetak gol terbanyakMorten Duncan Rasmussen (145)Televisi penyiarDomestikViaplay Group(TV3+, TV3 Sport, TV3 MAX)Discovery Networks Denmark(Canal 9, Eurosport 2)InternasionalEleven Spo…
Marci A. HamiltonCEO and Academic Director, CHILD USABorn (1957-07-22) July 22, 1957 (age 66)EducationVanderbilt University, Pennsylvania State University, University of PennsylvaniaOccupation(s)Constitutional Law, First Amendment, Religion and the LawWebsitewww.childusa.org Marci Ann Hamilton (born July 22, 1957) is the chief executive officer and academic director at Child USA, an interdisciplinary think tank to prevent child abuse and neglect. She is also a scholar of constitutional law …
United States historic placeGermania-Miller/Standard HotelU.S. National Register of Historic PlacesDavenport Register of Historic Properties No. 19[2] Show map of IowaShow map of the United StatesLocation712 W. 2nd St.Davenport, IowaCoordinates41°31′18″N 90°35′1″W / 41.52167°N 90.58361°W / 41.52167; -90.58361Area1 acre (0.40 ha)Built1871Architectural styleLate VictorianMPSDavenport MRANRHP reference No.83002438[1]D…
Hospital in Queens, New York Hospital in New York, United StatesJamaica Hospital Medical CenterMediSys Health NetworkJamaica Hospital, 2012GeographyLocationQueens, New York, United StatesCoordinates40°42′02″N 73°48′58″W / 40.7005°N 73.816°W / 40.7005; -73.816OrganizationFundingNon-profit[1]TypeTeaching[1]Affiliated universityNew York Institute of Technology College of Osteopathic MedicineNetworkMediSys Health NetworkServicesEmergency department…
Kay McNulty, Alyse Snyder en Sis Stump aan het werk in de Moore School of Electrical Engineering (circa 1942-1945) De Moore School of Electrical Engineering aan de Universiteit van Pennsylvania is vooral bekend als de plek waar de moderne computer is ontwikkeld. De faculteit is opgezet na een donatie van Alfred Fitler Moore op 4 juni 1923. Op de Moore School of Electrical Engineering werd tussen 1943 en 1946 de eerste Turing-complete digitale elektronische computer, de ENIAC, gebouwd. Deze compu…
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