Doubles
2021 MUSC Health Women's Open
Final
Champions	Hailey Baptiste Caty McNally
Runners-up	Ellen Perez Storm Sanders
Score	6–7(4–7), 6–4, [10–6]
Events
Singles Doubles
MUSC Health Women's Open · 2022 →

Hailey Baptiste and Caty McNally won the second 2021 Charleston Open, billed as the MUSC Health Women's Open, defeating Ellen Perez and Storm Sanders in the final, 6–7^(4–7), 6–4, [10–6]. This was Baptiste's first WTA doubles title.^[1]

The 50th playing of the tournament occurred immediately after the 49th playing in 2021. This featured consecutive events, with the 2021 Volvo Car Open being the first. The second Charleston tournament was organised with a single-year license in 2021.^[2]

	First round							Quarterfinals							Semifinals							Final
	1	E Perez S Sanders	6	6
		K Nara M Ninomiya	0	1				1	E Perez S Sanders	6	6
	PR	O Kalashnikova A Kudryavtseva	67	6	[2]				K Piter Y Wang	1	3
		K Piter Y Wang	79	2	[10]										1	E Perez S Sanders	6	6
	4	Ar Rodionova R van der Hoek	1	0r												J Wachaczyk R Zarazúa	2	2
		J Loeb E Routliffe	6	4					J Loeb E Routliffe	2	4
		E Bektas T Moore	4	1					J Wachaczyk R Zarazúa	6	6
		J Wachaczyk R Zarazúa	6	6																		1	E Perez S Sanders	77	4	[6]
		E Lechemia I Neel	64	7	[10]																		H Baptiste C McNally	64	6	[10]
		Q Gleason M Sanchez	77	5	[8]				E Lechemia I Neel	6	5	[10]
		N Broady A Sharma	w/o						N Broady A Sharma	3	7	[6]
	Alt	L Fruhvirtová T Martincová														E Lechemia I Neel	0	2
	WC	S Chang E Navarro	2	4												H Baptiste C McNally	6	6
		H Baptiste C McNally	6	6					H Baptiste C McNally	6	6
		B Gumulya J Rompies	77	3	[12]				B Gumulya J Rompies	0	0
	2	K Christian S Santamaria	62	6	[10]

• Main Draw