All competition rounds consist of a single game with a home field advantage granted to a team from lower league. Draw for all the rounds is blind. Qualification for the competition was granted to all professional clubs and two better of the 2020–21 Ukrainian Amateur Cup. Higher-tier teams enter the competition later (gain bye) than lower-tier teams.
At an extraordinary general meeting on 26 April 2022, the competition was abandoned due to the Russian invasion of Ukraine.
Team allocation and schedule
The competition includes all professional first teams from the Premier League (16/16 teams of the league), First League (16/16), Second League (31/31) and two semifinal teams from the previous year's Amateur Cup since two other semifinal teams joined ranks of the Second League including the winner LNZ Cherkasy.
Stadium: Livyj Bereh Attendance: 300 Referee: Y. Nazarov (Kharkiv)
Second preliminary round (1/64)
In this round, 16 clubs from the First League and 23 clubs from the Second League enter the competition and join the 5 winners of the First preliminary round (3 clubs from Second League, 2 – amateurs).
Stadium: Tsentralnyi Miskyi Stadion Attendance: 300 Referee: Ye.Kievlich (Kropyvnytskyi)
Round of 32
In this round, 11 clubs from the Premier League (lower ranked) enter the competition and join the 11 winners of the Third preliminary round (7 clubs from First League, 4 – Second League).
In this round, rest of 5 clubs from the Premier League (upper ranked) enter the competition and join the 11 winners of the Round of 32 (8 clubs from Premier League, 2 – First League, 1 – Second League).
The draw for round of 16 was held on 24 September 2021.[10]
This round includes one team from the First League (Metalist Kharkiv) and 7 clubs from the Premier League. Base date for the matches is 1–2–3 March 2022.
The draw for quarter-finals was held on 15 December 2021.[14]
^The match report from UAF has his name spelled as MochevYnskyi, yet the UAF database "FootPass" has his name as MochevInskyi, the same spelling is posted at the PFL website.
^The FC Mariupol – Dynamo Kyiv match was played without any spectators due to the COVID-19 pandemic in Ukraine and the unprecedented rise in infections in Donetsk oblast enacting the government to declare the region a "red zone" and thus issuing restrictions with gatherings.[11]
^The FC Alians Lypova Dolynal – FC Lviv match was played without any spectators due to the COVID-19 pandemic in Ukraine and the unprecedented rise in infections in the city of Sumy enacting the government to declare the region a "red zone" and thus issuing restrictions with gatherings.[12]
^The Round of 16 LNZ Cherkasy – SC Dnipro-1 was to be held 28 October 2021 but was postponed due to the coronavirus outbreak in the LNZ Cherkasy team.[13]