The 2021–22 Primera Divisió was the 27th season of top-tier football in Andorra. The season began on 19 September 2021.[1] The league champion qualified to compete in the 2022–23 UEFA Champions League.[2]
Penya Encarnada were relegated from the Primera Divisió after finishing in last place the previous season.[4]Ordino were promoted to the Primera Divisió having won the previous season's Segona Divisió title.[5]
The seventh-placed team, third-placed in the relegation round, from the Primera Divisió and the runners-up from the Segona Divisió played a play-off over two legs for a place in the 2022–23 Primera Divisió.