Sporting CP began the domestic season on 12 August 2018 with a 3–1 away win against Moreirense through two goals from Bas Dost and one from Bruno Fernandes. The first Lisbon derby against Benfica was played on 25 August (matchday 3), where a penalty goal from Nani was not enough for a win as the match finished 1–1 at Estádio da Luz.
Source: Liga Portugal Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Head-to-head away goals scored; 5) Goal difference; 6) Matches won; 7) Goals scored; 8) Play-off. (C) Champions Notes:
^ abcSince the winners of the 2018–19 Taça de Portugal, Sporting CP, qualified for European competition based on league position, the spot awarded to the third-placed team (Europa League third qualifying round) was passed to the fourth-placed team, and the spot awarded to the fourth-placed team (Europa League second qualifying round) was passed to the fifth-placed team.
^Vitória de Guimarães finished ahead of Moreirense on head-to-head points: Vitória de Guimarães 1–0 Moreirense, Moreirense 1–3 Vitória de Guimarães.