The year 1519 in science and technology included many events, some of which are listed here.

• September 20 – Ferdinand Magellan's fleet sets sail from Sanlúcar de Barrameda to find a westabout route to Asia.
• "Miller Atlas" produced in Portugal.

• A pandemic spreads from the Greater Antilles into Central America, and perhaps as far as Peru, killing much of the indigenous populations in these areas.^[1]
• Publication in Paris of Thomas Linacre's translation into Latin of Galen's Methodus medendi.

• June 6 – Andrea Cesalpino, Italian philosopher, physician, and botanist (died 1603)

• May 2 – Leonardo da Vinci, Italian polymath (born 1452)