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The year 1528 in science and technology included a number of events, some of which are listed here.

Events

February – Diego García de Moguer explores the Sierra de la Plata along the Río de la Plata and begins to travel up the Paraná River.^[1]
November 6 – Spanish conquistador Álvar Núñez Cabeza de Vaca and his companions become the first Europeans known to set foot on the territory of Texas.
Jean Fernel publishes Cosmotheoria, including a means of determining a degree of arc of the meridian.

May – The fourth major outbreak of the sweating sickness occurs in England,^[2] also spreading to northern Europe.

^ Los viajes de Diego García de Moguer.
^ Palmer, Alan; Palmer, Veronica (1992). The Chronology of British History. London: Century Ltd. pp. 142–145. ISBN 0-7126-5616-2.
^ Müller, Peter O. (1993). Substantiv-Derivation in den Schriften Albrecht Dürers. Berlin: Walter de Gruyter. ISBN 3-11-012815-2.
^ Wroth, Lawrence C. (1970). The Voyages of Giovanni da Verrazzano, 1524-1528. New Haven: Yale University Press. p. 237. ISBN 0-300-01207-1.