1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Identifiers
EC no.3.1.2.28
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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The enzyme 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (EC 3.1.2.28; systematic name 1,4-dihydroxy-2-naphthoyl-CoA hydrolase) catalyses the following reaction:[1][2][3]

1,4-dihydroxy-2-naphthoyl-CoA + H2O 1,4-dihydroxy-2-naphthoate + CoA

This enzyme participates in the biosynthesis of menaquinones, phylloquinone, and several plant pigments.

References

  1. ^ Widhalm, J.R.; van Oostende, C.; Furt, F.; Basset, G.J. (2009). "A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1". Proc. Natl. Acad. Sci. USA. 106 (14): 5599–5603. Bibcode:2009PNAS..106.5599W. doi:10.1073/pnas.0900738106. PMC 2660889. PMID 19321747.
  2. ^ Muller, W; Leistner, E (1976). "1,4-naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis". Phytochemistry. 15 (3): 407–410. doi:10.1016/s0031-9422(00)86833-8.
  3. ^ Eichinger D, Bacher A, Zenk MH, Eisenreich W (1999). "Quantitative assessment of metabolic flux by 13C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum". J. Am. Chem. Soc. 121 (33): 7469–7475. doi:10.1021/ja990622o.