Triflusal is a platelet aggregation inhibitor that was discovered and developed in the Uriach Laboratories, and commercialised in Spain since 1981. Currently, it is available in 25 countries in Europe, Asia, Africa and America. It is a derivative of acetylsalicylic acid (ASA; Aspirin) in which a hydrogen atom on the benzene ring has been replaced by a trifluoromethyl group. Trade names include Disgren, Grendis, Aflen and Triflux.[1]
Triflusal has multiple mechanisms of action that contribute to the effect of the drug. It is a COX-1 inhibitor. It also inhibits the activation of nuclear factor k-B, which in turn regulates the expression of the mRNA of the vascular cell adhesion molecule-1 needed for platelet aggregation. Additionally, Triflusal preserves vascular prostacyclin which yields an anti-platelet effect. Triflusal also blocks phosphodiesterase, increasing cAMP concentration as well as can increase nitric oxide synthesis in neutrophils.
Triflusal is a selective platelet antiaggregant through;
Triflusal is indicated for;
In the 2008, guidelines for stroke management from the European Stroke Organization,[3] triflusal was for the first time recommended as lone therapy, as an alternative to acetylsalicylic acid (ASA)(Aspirin) plus dipyridamole, or clopidogrel alone for secondary prevention of atherothrombotic stroke. This recommendation was based on the double-blind, randomised TACIP and TAPIRSS trials, which found triflusal to be as effective as Aspirin (acetylsalicylic acid, ASA, which Triflusal is derived from) in preventing post-stroke vascular events, while having a more favourable safety profile.[4][5][6]
It is absorbed in the small intestine and its bio-availability ranges from 83% to 100%.[7][8] The active metabolite of Triflusal is 2-hydroxy-4-trifluoromethyl-benzoic acid, which is when Triflusal gets metabolized by an esterase.
Overview of the role of Buddhism in Thailand Buddhism in ThailandWat Phra Kaew, one of the most sacred wats in BangkokTotal populationc. 64 million (95%) in 2015[1][2]Regions with significant populationsThroughout ThailandReligions Theravada BuddhismLanguagesThai and other languages Part of a series onTheravāda Buddhism Countries Bangladesh Cambodia China India Laos Myanmar Nepal Sri Lanka Thailand Vietnam Western world Texts Pāli Tipiṭaka Paracanonical texts Commentari…
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Документація шаблону Шаблон:Дані країни Угорська Народна Республіка внутрішній контейнер даних не призначений для безпосереднього використання. Він використовується побічно через такі шаблони, як ПрапорТекст, ПрапорЗначок тощо. Шаблон є частиною проєкту ВікіПроєкту Ш
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