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Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Transforming growth factor beta receptor 2 ectodomain
Transforming growth factor beta receptor 2 ectodomain
	crystal structure of human tgf-beta type ii receptor ligand binding domain
Identifiers
Symbol	ecTbetaR2
Pfam	PF08917
InterPro	IPR015013
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

TGFBR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KTZ, 1M9Z, 1PLO, 2PJY, 3KFD, 4P7U, 4XJJ, 5E92, 5E91, 5E8V, 5E8Y
Identifiers
Aliases	TGFBR2, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII, transforming growth factor beta receptor 2, TBR-ii, TBRII
External IDs	OMIM: 190182; MGI: 98729; HomoloGene: 2435; GeneCards: TGFBR2; OMA:TGFBR2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	30,694,142 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	116,004,428 bp
RNA expression pattern
	Top expressed in
	pericardium; ; tibia; ; parietal pleura; ; epithelium of colon; ; lower lobe of lung; ; visceral pleura; ; vena cava; ; superficial temporal artery; ; cardiac muscle tissue of right atrium; ; synovial joint;
	Top expressed in
	left lung lobe; ; gastrula; ; calvaria; ; decidua; ; lymph node; ; stroma of bone marrow; ; sciatic nerve; ; endothelial cell of lymphatic vessel; ; mesenteric lymph nodes; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transforming growth factor beta-activated receptor activity; kinase activity; ATP binding; type III transforming growth factor beta receptor binding; protein kinase activity; transforming growth factor beta receptor activity, type II; metal ion binding; protein serine/threonine kinase activity; transferase activity; type I transforming growth factor beta receptor binding; mitogen-activated protein kinase kinase kinase binding; protein binding; SMAD binding; nucleotide binding; glycosaminoglycan binding; transforming growth factor beta binding; transmembrane receptor protein serine/threonine kinase activity; signaling receptor activity; growth factor binding;
Cellular component	cytoplasm; cytosol; membrane; caveola; cell surface; membrane raft; integral component of membrane; receptor complex; plasma membrane; integral component of plasma membrane; external side of plasma membrane;
Biological process	growth plate cartilage development; response to cholesterol; lens fiber cell apoptotic process; response to steroid hormone; positive regulation of T cell tolerance induction; receptor-mediated endocytosis; response to organic substance; vasculogenesis; protein phosphorylation; positive regulation of B cell tolerance induction; positive regulation of reactive oxygen species metabolic process; blood vessel development; positive regulation of mesenchymal cell proliferation; animal organ regeneration; animal organ morphogenesis; transforming growth factor beta receptor signaling pathway; embryo implantation; negative regulation of cell population proliferation; apoptotic process; pathway-restricted SMAD protein phosphorylation; common-partner SMAD protein phosphorylation; bronchus morphogenesis; lung development; response to mechanical stimulus; positive regulation of epithelial cell migration; in utero embryonic development; negative regulation of transforming growth factor beta receptor signaling pathway; heart development; cartilage development; positive regulation of tolerance induction to self antigen; branching involved in blood vessel morphogenesis; positive regulation of skeletal muscle tissue regeneration; smoothened signaling pathway; negative regulation of cardiac muscle cell proliferation; Notch signaling pathway; cell differentiation; phosphorylation; response to nutrient; mammary gland morphogenesis; wound healing; response to glucose; positive regulation of epithelial to mesenchymal transition; positive regulation of angiogenesis; response to estrogen; gastrulation; regulation of gene expression; embryonic cranial skeleton morphogenesis; peptidyl-threonine phosphorylation; trachea formation; lung lobe morphogenesis; positive regulation of smooth muscle cell proliferation; lung morphogenesis; response to organic cyclic compound; trachea morphogenesis; ageing; myeloid dendritic cell differentiation; bronchus development; brain development; transmembrane receptor protein serine/threonine kinase signaling pathway; lens development in camera-type eye; regulation of cell population proliferation; peptidyl-serine phosphorylation; positive regulation of cell population proliferation; embryonic hemopoiesis; growth plate cartilage chondrocyte growth; regulation of growth; positive regulation of NK T cell differentiation; digestive tract development; activation of protein kinase activity; response to hypoxia; heart looping; outflow tract septum morphogenesis; membranous septum morphogenesis; outflow tract morphogenesis; atrioventricular valve morphogenesis; tricuspid valve morphogenesis; cardiac left ventricle morphogenesis; endocardial cushion fusion; ventricular septum morphogenesis; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; cell proliferation involved in endocardial cushion morphogenesis; positive regulation of CD4-positive, alpha-beta T cell proliferation; superior endocardial cushion morphogenesis; inferior endocardial cushion morphogenesis; miRNA transport; secondary palate development; pattern specification process;
	Sources:Amigo / QuickGO
Orthologs
	7048
	21813
	ENSG00000163513
	ENSMUSG00000032440
	P37173
	Q62312
	NM_001024847; NM_003242
	NM_009371; NM_029575
	NP_001020018; NP_003233
	NP_033397; NP_083851
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene.

It is a tumor suppressor gene.^[5]

Function

This gene encodes a member of the serine/threonine protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler–Weber–Rendu syndrome, and the development of various types of tumors. At least 73 disease-causing mutations in this gene have been discovered.^[6] Alternatively spliced transcript variants encoding different isoforms have been characterized.^[7]

Interactions

TGF beta receptor 2 has been shown to interact with:

Domain architecture

TGF beta receptor 2 consists of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).^[18]