Sitagliptin

Sitagliptin
Clinical data
Pronunciation/sɪtəˈɡlɪptɪn/ ⓘ
Trade namesJanuvia, Zituvio, others
AHFS/Drugs.comMonograph
MedlinePlusa606023
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability87%
Protein binding38%
MetabolismLiver (CYP3A4- and CYP2C8-mediated)
Elimination half-life8 to 14 h[7]
ExcretionKidney (80%)[7]
Identifiers
  • (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.217.948 Edit this at Wikidata
Chemical and physical data
FormulaC16H15F6N5O
Molar mass407.320 g·mol−1
3D model (JSmol)
  • Fc1cc(c(F)cc1F)C[C@@H](N)CC(=O)N3Cc2nnc(n2CC3)C(F)(F)F
  • InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1 checkY
  • Key:MFFMDFFZMYYVKS-SECBINFHSA-N checkY
  (verify)

Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes.[8] In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea.[9] It is taken by mouth.[8] It is also available in the fixed-dose combination medication sitagliptin/metformin (Janumet, Janumet XR).[8]

Common side effects include headaches, swelling of the legs, and upper respiratory tract infections.[8] Serious side effects may include angioedema, low blood sugar, kidney problems, pancreatitis, and joint pain.[8] Whether use in pregnancy or breastfeeding is safe is unclear.[10] It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decreasing the production of glucagon by the pancreas.[8]

Sitagliptin was developed by Merck & Co. and approved for medical use in the United States in 2006.[8] In 2022, it was the 86th most commonly prescribed medication in the United States, with more than 7 million prescriptions.[11][12] It is available as a generic medication.[13][14][15]

Medical uses

Sitagliptin is used to treat type 2 diabetes.[8] It is generally less preferred than metformin or sulfonylureas.[9] It is taken by mouth.[8] It is also available as the fixed-dose combinations of sitagliptin/metformin (Janumet, Janumet XR)[8] and sitagliptin/simvastatin (Juvisync).[16]

Sitagliptin should not be used to treat type 1 diabetes. In December 2020, the US Food and Drug Administration (FDA) approved labeling changes stating that Januvia (sitagliptin), Janumet (sitagliptin and metformin hydrochloride), and Janumet XR (sitagliptin and metformin hydrochloride extended-release) are not proven to improve glycemic (blood sugar) control in children aged 10 to 17 with type 2 diabetes.[17] The drugs are approved to improve blood sugar control in adults aged 18 and older with type 2 diabetes.[17]

Adverse effects

Adverse effects from sitagliptin are similar to placebo, except for rare nausea, common cold-like symptoms, and photosensitivity.[18] It does not increase the risk of diarrhea.[19] No significant difference exists in the occurrence of hypoglycemia between placebo and sitagliptin.[18][20][21] In those taking sulphonylureas, the risk of low blood sugar is increased.[22]

The existence of rare case reports of kidney failure and hypersensitivity reactions is noted in the United States prescribing information, but a causative role for sitagliptin has not been established.[2]

Several postmarketing reports of pancreatitis (some fatal) have been made in people treated with sitagliptin and other DPP-4 inhibitors,[23][24] and the US FDA package insert carries a warning to this effect,[2] although the causal link between sitagliptin and pancreatitis has not yet been fully substantiated.[25] One study with lab rats published in 2009 concluded that some of the possible risks of pancreatitis or pancreatic cancer may be reduced when it is used with metformin. However, while DPP-4 inhibitors showed an increase in such risk factors, as of 2009, no increase in pancreatic cancer has been reported in individuals taking DPP-4 inhibitors.[26]

In 2015, the US Food and Drug Administration (FDA) added a new warning and precaution about the risk of "severe and disabling" joint pain to the labels of all DPP-4 inhibitor medicines.[27]

Mechanism of action

See also: Dipeptidyl peptidase-4 inhibitors

Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones released in response to a meal.[28] By preventing breakdown of GLP-1 and GIP, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas.[medical citation needed] This drives blood glucose levels towards normal.[medical citation needed] As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an "overshoot" and subsequent low blood sugar (hypoglycemia), which is seen with some other oral hypoglycemic agents.[medical citation needed]

Sitagliptin has been shown to lower HbA1c level by about 0.7% points versus placebo. It is slightly less effective than metformin when used as a monotherapy. It does not cause weight gain and has less hypoglycemia compared to sulfonylureas. Sitagliptin is recommended as a second-line drug (in combination with other drugs) after the combination of diet/exercise and metformin fails.[29]

History

See also: Development of dipeptidyl peptidase-4 inhibitors

Sitagliptin was approved by the US Food and Drug Administration (FDA) in October 2006,[30] and is sold under the brand name Januvia.[31] In April 2007, the FDA approved an oral combination of sitagliptin/metformin sold under the brand name Janumet.[32] In October 2011, the FDA approved an oral combination of sitagliptin/simvastatin sold under the brand name Juvisync.[33][16] The extended release version of sitagliptin/metformin was approved in February 2012.[34]

References

  1. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved March 24, 2024.
  2. ^ a b c "Januvia- sitagliptin tablet, film coated". DailyMed. Archived from the original on October 27, 2021. Retrieved October 15, 2021.
  3. ^ "Zituvio- sitagliptin tablet". DailyMed. November 1, 2023. Retrieved December 25, 2023.
  4. ^ "Zituvio- sitagliptin tablet". DailyMed. November 1, 2023. Retrieved December 25, 2023.
  5. ^ "Januvia EPAR". European Medicines Agency. September 17, 2018. Archived from the original on October 23, 2021. Retrieved October 15, 2021.
  6. ^ "Xelevia EPAR". European Medicines Agency (EMA). March 21, 2007. Retrieved October 19, 2024.
  7. ^ a b Herman GA, Stevens C, van Dyck K, Bergman A, Yi B, De Smet M, et al. (December 2005). "Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses". Clinical Pharmacology and Therapeutics. 78 (6): 675–688. doi:10.1016/j.clpt.2005.09.002. PMID 16338283. S2CID 20935646.{{cite journal}}: CS1 maint: overridden setting (link)
  8. ^ a b c d e f g h i j "Sitagliptin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on March 4, 2016. Retrieved March 3, 2019.
  9. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 681. ISBN 9780857113382.
  10. ^ "Sitagliptin Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on March 6, 2019. Retrieved March 3, 2019.
  11. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on August 30, 2024. Retrieved August 30, 2024.
  12. ^ "Sitagliptin Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved August 30, 2024.
  13. ^ "Generic Januvia Availability". Drugs.com. Retrieved December 1, 2023.
  14. ^ "JAMP Pharma Group receives Health Canada approval for PrJAMP Sitagliptin, a new generic alternative for the treatment of type 2 diabetes" (Press release). JAMP Pharma. January 6, 2023. Retrieved June 19, 2023 – via Newswire.
  15. ^ "Sitagliptin SUN EPAR". European Medicines Agency (EMA). December 9, 2021. Retrieved September 27, 2024.
  16. ^ a b "FDA Approves Combination Therapy Juvisync" (Press release). U.S. Food and Drug Administration (FDA). October 7, 2011. Archived from the original on August 24, 2014. Retrieved November 17, 2013.
  17. ^ a b "Diabetes drug not proven to improve blood sugar in pediatric patients". U.S. Food and Drug Administration (FDA). December 4, 2020. Archived from the original on December 4, 2020. Retrieved December 5, 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  18. ^ a b "Januvia Side Effects & Drug Interactions". RxList.com. 2007. Archived from the original on November 20, 2007. Retrieved November 28, 2007.
  19. ^ Zhao Q, Hong D, Zheng D, Xiao Y, Wu B (2014). "Risk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials". Drug Design, Development and Therapy. 8: 2283–2294. doi:10.2147/DDDT.S70945. PMC 4234286. PMID 25419118.
  20. ^ Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP (February 2012). "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia®)". Dermatology Online Journal. 18 (2): 9. doi:10.5070/D30D70K7B2. PMID 22398230. Archived from the original on April 8, 2019. Retrieved June 6, 2019.
  21. ^ "Januvia side effect: Photosensitivity reaction - eHealthMe". www.ehealthme.com. Archived from the original on June 7, 2019. Retrieved June 6, 2019.
  22. ^ Salvo F, Moore N, Arnaud M, Robinson P, Raschi E, De Ponti F, et al. (May 2016). "Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia: systematic review and meta-analysis". BMJ. 353: i2231. doi:10.1136/bmj.i2231. PMC 4854021. PMID 27142267.{{cite journal}}: CS1 maint: overridden setting (link)
  23. ^ Olansky L (January 2010). "Do incretin-based therapies cause acute pancreatitis?". Journal of Diabetes Science and Technology. 4 (1): 228–229. doi:10.1177/193229681000400129. PMC 2825646. PMID 20167189.
  24. ^ "FDA Drug Safety Communication: FDA investigating reports of possible increased risk of pancreatitis and pre-cancerous findings of the pancreas from incretin mimetic drugs for type 2 diabetes". U.S. Food and Drug Administration (FDA). June 21, 2019. Archived from the original on May 10, 2022. Retrieved May 10, 2022.
  25. ^ National Prescribing Service (August 2010). "Sitagliptin for Type 2 Diabetes". Archived from the original on July 18, 2010. Retrieved August 27, 2010.
  26. ^ Matveyenko AV, Dry S, Cox HI, Moshtaghian A, Gurlo T, Galasso R, et al. (July 2009). "Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin". Diabetes. 58 (7): 1604–1615. doi:10.2337/db09-0058. PMC 2699878. PMID 19403868.{{cite journal}}: CS1 maint: overridden setting (link)
  27. ^ "DPP-4 Inhibitors for Type 2 Diabetes: Drug Safety Communication—May Cause Severe Joint Pain". U.S. Food and Drug Administration (FDA). August 28, 2015. Archived from the original on December 13, 2019. Retrieved September 1, 2015.
  28. ^ Herman GA, Bergman A, Liu F, Stevens C, Wang AQ, Zeng W, et al. (August 2006). "Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects". Journal of Clinical Pharmacology. 46 (8): 876–886. doi:10.1177/0091270006289850. PMID 16855072. S2CID 45849328.{{cite journal}}: CS1 maint: overridden setting (link)
  29. ^ Gadsby R (2009). "Efficacy and Safety of Sitagliptin in the Treatment of Type 2 Diabetes". Clinical Medicine: Therapeutics. 1 (1): 53–62. doi:10.4137/CMT.S2313.
  30. ^ "FDA Approves New Treatment for Diabetes" (Press release). U.S. Food and Drug Administration (FDA). October 17, 2006. Archived from the original on February 28, 2009. Retrieved October 17, 2006.
  31. ^ "Drug Approval Package: Januvia (Sitagliptin Phosphate) NDA #021995". U.S. Food and Drug Administration (FDA). Retrieved September 27, 2024.
  32. ^ "Drug Approval Package: Janumet (Sitagliptin/Metformin Hydrochloride) NDA #022044". U.S. Food and Drug Administration (FDA). July 8, 2008. Retrieved September 27, 2024.
  33. ^ "Drug Approval Package: Juvisync (sitagliptin and simvastatin fixed-dose combination) Tablets NDA #202343". U.S. Food and Drug Administration (FDA). July 13, 2012. Retrieved September 27, 2024.
  34. ^ "Drug Approval Package: Janumet XR (sitagliptin/metformin hydrochloride) NDA #202270". U.S. Food and Drug Administration (FDA). September 3, 2013. Retrieved September 27, 2024.

Read other articles:

Nova Mahanes Yudha

Nova Mahanes Yudha Dosen Madya SeskoadPetahanaMulai menjabat 16 April 2022Komandan Resimen Artileri Pertahanan Udara 1/FaletehanMasa jabatan4 Desember 2020 – 16 April 2022 PendahuluCandy Christian RiantoryPenggantiGunawan WibisonoDandim 0312/PadangMasa jabatan21 Agustus 2019 – 4 Desember 2020 PendahuluRielman Noordien Yudha Tri AnandaPenggantiM Ghoffar Ngismangil Informasi pribadiLahir9 November 1975 (umur 48)Alma materAkademi Militer (1998)Karier militerPihak&#...

 

Angkatan Pertahanan Irlandia

Angkatan Pertahanan (Irlandia: Fórsaí Cosanta,  secara resmi disebut Óglaigh na hÉireann) adalah angkatan bersenjata Irlandia. Mereka mencakup Angkatan Darat, Korps Udara, Angkatan Laut, dan Pasukan Pertahanan Cadangan.[1]Angkatan Pertahanan IrlandiaFórsaí CosantaÓglaigh na hÉireannLambang Angkatan Pertahanan IrlandiaDidirikanFebruari 1922Formasi terkini1 Oktober 1924Angkatan  Angkatan Darat Irlandia Korps Udara Irlandia  Angkatan Laut Irlandia Pasukan Pertahana...

 

Akbar Ali

Akbar Ali Penjabat Wali Kota PareparePetahanaMulai menjabat 31 Oktober 2023PresidenJoko WidodoGubernurBahtiar Baharuddin (Pj.) PendahuluTaufan PawePenggantiPetahana Informasi pribadiLahir(1975-04-02)2 April 1975 Sidenreng Rappang Sulawesi, IndonesiaKebangsaanIndonesiaPartai politikIndependenProfesiASNSunting kotak info • L • B Dr. Drs. Akbar Ali, A.P., M.Si. (lahir 2 April 1975) adalah seorang birokrat asal Indonesia kelahiran Tanrutedong, Sidenreng Rappang, Sulawesi Selatan...

Step into the Light / Failure Will Follow

2023 studio album by the Acacia StrainStep into the Light / Failure Will FollowStep into the Light coverStudio album by the Acacia StrainReleasedMay 12, 2023[1][2]Recorded2022GenreStep Into the Light: Deathcore, metalcore[3] Failure Will Follow: Sludge metal, doom metal[4]Length23:33 (Step Into the Light)38:42 (Failure Will Follow)62:15 (total)LabelRiseProducerRandy LeBoeufThe Acacia Strain chronology Slow Decay(2020) Step into the Light / Failure Will...

 

1928 North Dakota gubernatorial election

Election for the governor of North Dakota For related races, see 1928 United States gubernatorial elections. 1928 North Dakota gubernatorial election ← 1926 November 6, 1928 1930 →   Nominee George F. Shafer Walter Maddock Party Republican Democratic Popular vote 131,193 100,205 Percentage 56.50% 43.15% County results Shafer:      50–60%      60–70%      70–80% Maddock:   ...

 

Kostanaï

Cet article est une ébauche concernant une localité kazakhe. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Kostanaï Qostanai Héraldique Le centre de Kostanaï. Administration Pays Kazakhstan Oblys Kostanaï Code postal 110000 Indicatif téléphonique +7 7142 Démographie Population 252 115 hab. (2009[1]) Densité 341 hab./km2 Géographie Coordonnées 53° 12′ nord, 63° 38�...

Campaign setting

Fictional environment setting for a role-playing game This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Campaign setting – news · newspapers · books · scholar ...

 

Rize

Disambiguazione – Se stai cercando il film documentario, vedi Rize - Alzati e balla. RizecomuneRize – Veduta LocalizzazioneStato Turchia RegioneMar Nero ProvinciaRize DistrettoRize TerritorioCoordinate41°01′29″N 40°31′20″E / 41.024722°N 40.522222°E41.024722; 40.522222 (Rize)Coordinate: 41°01′29″N 40°31′20″E / 41.024722°N 40.522222°E41.024722; 40.522222 (Rize) Altitudine6 m s.l.m. Superficie250,14 km² Abitanti14...

 

Keuskupan Matehuala

Keuskupan MatehualaDioecesis MatehualensisDiócesis de MatehualaKatolik Catedral de la Inmaculada ConcepciónLokasiNegaraMeksikoProvinsi gerejawiProvinsi San Luis PotosíStatistikLuas10.394 sq mi (26.920 km2)Populasi- Total- Katolik(per 2004)249.692213,812 (85.6%)Paroki17InformasiDenominasiKatolik RomaRitusRitus RomaPendirian28 Mei 1997 (26 tahun lalu)KatedralKatedral Dikandung Tanpa NodaKepemimpinan kiniPausFransiskusUskupMargarito Salazar CárdenasUskup ag...

Dragomir Karić

Serbian entrepreneur and politician Karić in 2017 Dragomir Dragan Karić (Serbian Cyrillic: Драгомир Драган Карић; born 21 October 1949) is an entrepreneur and politician in Serbia. A close ally of his younger brother Bogoljub Karić, he has been a prominent figure in Serbia's business community since the 1980s. He has served in the National Assembly of Serbia since 2012 as a member of the Strength of Serbia Movement (Pokret snaga Srbije, PSS). Early life and career Karić...

 

Stepmom (1998 film)

Film by Chris Columbus StepmomTheatrical release posterDirected byChris ColumbusScreenplay by Gigi Levangie Jessie Nelson Steven Rogers Karen Leigh Hopkins Ron Bass Story byGigi LevangieProduced by Wendy Finerman Chris Columbus Mark Radcliffe Michael Barnathan Starring Julia Roberts Susan Sarandon Ed Harris CinematographyDonald McAlpineEdited byNeil TravisMusic byJohn WilliamsProductioncompanies Columbia Pictures 1492 Pictures Distributed bySony Pictures ReleasingRelease date December 25...

 

طول (جغرافيا)

  لمعانٍ أخرى، طالع طول (توضيح).   هذه المقالة عن الإحداثي الجغرافي المسمى بالطول. لنصف دائرة وهمية تمر بقطبي الأرض، طالع خط طول. طول جغرافيالطول الجغرافي λ والعرض الجغرافي ϕمعلومات عامةصنف فرعي من كمية فيزيائية جزء من إحداثي جغرافي رمز الكمية λ البعد حسب النظام ا�...

梅拉蒂·达伊瓦·奥克塔维亚尼

梅拉蒂·达伊瓦·奥克塔维亚尼Melati Daeva Oktavianti基本資料代表國家/地區 印度尼西亞出生 (1994-10-28) 1994年10月28日（29歲）[1] 印度尼西亞万丹省西冷[1]身高1.68米（5英尺6英寸）[1]握拍右手[1]主項：女子雙打、混合雙打職業戰績48勝–27負（女雙）109勝–56負（混雙）最高世界排名第4位（混雙-普拉文·喬丹）（2020年3月17日[2]）現時世界排名第...

 

Tomakomai

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Tomakomai – news · newspapers · books · scholar · JSTOR (January 2014) (Learn how and when to remove this message) City in Hokkaido, JapanTomakomai 苫小牧市City FlagSealLocation of Tomakomai in Hokkaido (Iburi Subprefecture)TomakomaiLocation in JapanCoordin...

 

Cabarrus County, North Carolina

County in North Carolina, United States Cabarrus redirects here. For people with that name, see Cabarrus (surname). County in North CarolinaCabarrus CountyCountyOld Cabarrus County Courthouse FlagSealLogoMotto: America Thrives HereLocation within the U.S. state of North CarolinaNorth Carolina's location within the U.S.Coordinates: 35°23′N 80°33′W / 35.39°N 80.55°W / 35.39; -80.55Country United StatesState North CarolinaFounded1792Named forStephen...

Thousand Oaks, California

Thousand Oaks redirects here. For the neighborhood of Berkeley, see Thousand Oaks, Berkeley, California. For other uses, see Thousand Oaks (disambiguation). City in California, United StatesThousand OaksCityMount Clef Ridge as seen from Tarantula Hill, Thousand Oaks SealLocation in Ventura County, CaliforniaThousand OaksLocation in the Los Angeles Metropolitan AreaShow map of the Los Angeles metropolitan areaThousand OaksLocation in CaliforniaShow map of CaliforniaThousand OaksLocation in the...

 

Lennon–McCartney

Foto Lennon McCartney Lennon-McCartney (atau McCartney-Lennon pada beberapa lagu) adalah sebutan untuk kemitraan John Lennon dan Paul McCartney dalam menciptakan lagu. Secara keliru, kadang ditulis Lennon/McCartney, dan yang benar adalah dengan garis datar, bukan garis miring. Lennon-McCartney adalah salah satu kerjasama penciptaan lagu yang paling terkenal dan paling berhasil hingga saat ini. Pada sebuah kesepakatan yang dicapai pada tahun-tahun awal mereka menulis lagu, keduanya setuju untu...

 

President of the Congress of Deputies

Presiding officer of the Spanish Congress of Deputies For a list of presidents of the Congress, see List of presidents of the Congress of Deputies of Spain. President of the Congress of DeputiesCoat of Arms of the Congress of DeputiesIncumbentFrancina Armengolsince 17 August 2023Congress of DeputiesStyleThe Most ExcellentSeatPalacio de las Cortes, MadridAppointerCongress of DeputiesTerm lengthFour years, renewableConstituting instrumentSpanish ConstitutionFormation24 September 1810&...

Siegfried (mythologie)

Pour les articles homonymes, voir Siegfried. SiegfriedBiographieActivités Explorateur, aventurier, SauroctonesPère SigmundMère Hjördís (en)Conjoints BrunehildeKriemhildEnfants SvanhildrAslaugAutres informationsPropriétaire de Gram, Hrotti, Balmung (d)Vénéré par Mythologie nordiquemodifier - modifier le code - modifier Wikidata Représentation de Sigurd dans une édition suédoise de 1893 de l'Edda poétique. Sigurd (Sigurðr en vieux norrois) est un héros légendaire de la mytholog...

 

Лёгкая атлетика на летних Олимпийских играх 2024 — бег на 1500 метров (мужчины)

Лёгкая атлетика налетних Олимпийских играх 2024 Беговые дисциплины 100 метров мужчины женщины 200 метров мужчины женщины 400 метров мужчины женщины 800 метров мужчины женщины 1500 метров мужчины женщины 5000 метров мужчины женщины 10 000 метров мужчины женщины 100 метров с барьерами �...