Zenarestat

Zenarestat
Names
Preferred IUPAC name
{3-[(4-Bromo-2-fluorophenyl)methyl]-7-chloro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}acetic acid
Identifiers
3D model (JSmol)
ChemSpider
KEGG
UNII
  • InChI=1S/C17H11BrClFN2O4/c18-10-2-1-9(13(20)5-10)7-22-16(25)12-4-3-11(19)6-14(12)21(17(22)26)8-15(23)24/h1-6H,7-8H2,(H,23,24)
    Key: SXONDGSPUVNZLO-UHFFFAOYSA-N
  • InChI=1/C17H11BrClFN2O4/c18-10-2-1-9(13(20)5-10)7-22-16(25)12-4-3-11(19)6-14(12)21(17(22)26)8-15(23)24/h1-6H,7-8H2,(H,23,24)
    Key: SXONDGSPUVNZLO-UHFFFAOYAB
  • C1=CC2=C(C=C1Cl)N(C(=O)N(C2=O)CC3=C(C=C(C=C3)Br)F)CC(=O)O
Properties
C17H11BrClFN2O4
Molar mass 441.64 g/mol
Melting point 223 to 224 °C (433 to 435 °F; 496 to 497 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Zenarestat (FK-366; FR-74366) is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract, but its development was terminated.[1]

References

  • M. Hashimoto et al., EP 218999; eidem, US 4734419 (1987, 1988 both to Fujisawa)
  • Inhibition kinetics and effect on sorbitol accumulation: S. Ao et al., Metabolism 40, 77 (1991)
  • Pharmacokinetics and metabolism in diabetic rats: Y. Tanaka et al., Drug Metab. Dispos. 21, 677 (1993)
  • M. Kanamaru et al., J. Clin. Pharmacol. 33, 1122 (1993).


  1. ^ "Zenarestat — AdisInsight". Adis Insight. Springer International Publishing AG. Retrieved 3 January 2016.
Stub icon

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

Read other articles:

Universitas Negeri Yogyakarta

Artikel ini berisi konten yang ditulis dengan gaya sebuah iklan. Bantulah memperbaiki artikel ini dengan menghapus konten yang dianggap sebagai spam dan pranala luar yang tidak sesuai, dan tambahkan konten ensiklopedis yang ditulis dari sudut pandang netral dan sesuai dengan kebijakan Wikipedia. Universitas Negeri Yogyakartaꦈꦤꦶꦮ꦳ꦼꦂꦱꦶꦠꦱ꧀​ꦤꦒꦫꦶ​ꦔꦪꦺꦴꦒꦾꦏꦂꦠLambang Universitas Negeri YogyakartaNama sebelumnya• Fakultas Pedagogi Universitas Gadj...

 

 

Hamamelidaceae

Hamamelidaceae Fothergilla major Klasifikasi ilmiah Kerajaan: Plantae Divisi: Magnoliophyta (tanpa takson): Eudikotil (tanpa takson): Core Eudikotil Ordo: Saxifragales Famili: Hamamelidaceae Genera Lihat teks Hamamelidaceae atau Keluarga Witch Hazel adalah salah satu suku anggota tumbuhan berbunga. Menurut Sistem klasifikasi APG II suku ini dimasukkan ke dalam bangsa Saxifragales, klad dikotil sejati inti (core Eudikotil) namun tidak termasuk ke dalam dua kelompok besar, Rosidae dan asterida...

 

 

Grameen Bank

Cet article est une ébauche concernant la finance. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Grameen BankHistoireFondation 1983CadreType BanqueDomaines d'activité Banque éthique, service financier, Activités de services financiers, à l’exception des assurances et des caisses de retraite.Siège Take-shimaPays  JaponOrganisationFondateur Muhammad YunusRécompenses Prix Gandhi pour la paix (2000)P...

Rumak, Kediri, Lombok Barat

{{desa |peta = |nama =Rumak |provinsi =Nusa Tenggara Barat |dati2 =Kabupaten |nama dati2 =Lombok Barat |kecamatan =Kediri |kode pos =83362 |luas =... km² |penduduk =... jiwa |kepadatan =... jiwa/km² |Periode. =... 2023 Rumak adalah desa yang berada di kecamatan Kediri, Kabupaten Lombok Barat, Nusa Tenggara Barat, Indonesia. Desa Rumak terdiri dari empat dusun, yaitu Dusun Rumak Timur Utara, Dusun Rumak Timur Selatan, Dusun Rumak Barat Utara dan Dusun Rumak Barat Selatan. Saat ini (2022) dip...

 

 

Sungai Aras

ArasLokasiNegaraTurki, Armenia, Iran, AzerbaijanCiri-ciri fisikHulu sungai  - lokasiProvinsi Erzurum, Turki Muara sungai  - lokasiSungai Kura di Sabirabad (kota)Panjang1,072 km (0,666 mi)Debit air  - rata-rata285 m3/s (10.100 cu ft/s) Daerah Aliran SungaiLuas DAS102,000 km2 (39,382 sq mi) Sungai Aras adalah sebuah sungai yang bermula di Turki dan kemudian mengalir di sepanjang perbatasan antara Turki dan Arme...

 

 

Ritodrine

Chemical compound RitodrineClinical dataPronunciation/ˈraɪtoʊdriːn/ RY-toh-dreen AHFS/Drugs.comMicromedex Detailed Consumer InformationRoutes ofadministrationOral (tablets), parenteral (IV)ATC codeG02CA01 (WHO) Legal statusLegal status US: Discontinued Pharmacokinetic dataProtein binding~56%MetabolismHepatic, metabolites are inactive[1]Elimination half-life1.7–2.6 hoursIdentifiers IUPAC name 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]...

Bukan Cinderella (film)

Untuk kegunaan lain, lihat Bukan Cinderella. Bukan CinderellaPoster resmiSutradaraAdi GarinProduserUnchu ViejaySkenarioQueenBCeritaDhety AzmiBerdasarkanBukan Cinderellaoleh Dhety AzmiPemeran Fujianti Utami Rafael Adwel Penata musikGanden BramantoSinematograferFachmi J SaadPenyuntingAugit PrimaPerusahaanproduksiSuper Media PicturesTanggal rilis 28 Juli 2022 (2022-07-28) (Indonesia) Durasi88 menitNegaraIndonesiaBahasaBahasa Indonesia Bukan Cinderella adalah film drama komedi roma...

 

 

Kevin Cash

American baseball player and manager Not to be confused with Kevin Clash. Baseball player Kevin CashCash in 2015Tampa Bay Rays – No. 16Catcher / ManagerBorn: (1977-12-06) December 6, 1977 (age 46)Tampa, Florida, U.S.Batted: RightThrew: RightMLB debutSeptember 6, 2002, for the Toronto Blue JaysLast MLB appearanceOctober 3, 2010, for the Boston Red SoxMLB statistics (through April 7, 2024)Batting average.183Home runs12Runs batted in58Managerial record744–6...

 

 

Soviet submarine K-219

A Project 667A Navaga-class ballistic missile submarine US Navy photo of K-219 on the surface after suffering a fire in a missile tube History Soviet Union NameK-219 Laid down28 May 1970 Launched8 October 1971 Commissioned31 December 1971 Stricken1986 HomeportGadzhiyevo FateSunk by explosion and fire caused by seawater leak in missile tube, 3 October 1986 General characteristics Class and typeYankee-class submarine Displacement 7,766 long tons (7,891 t) surfaced 9,300 long tons (9,449...

Southpaw - L'ultima sfida

Southpaw - L'ultima sfidaJake Gyllenhaal in una scena del filmTitolo originaleSouthpaw Lingua originaleinglese Paese di produzioneStati Uniti d'America, Cina Anno2015 Durata124 min Rapporto2,35:1 Generedrammatico, sportivo RegiaAntoine Fuqua SoggettoKurt Sutter SceneggiaturaKurt Sutter ProduttoreTodd Black, Jason Blumenthal, Antoine Fuqua, Alan Riche, Peter Riche, Steve Tisch Produttore esecutivoDylan Sellers, Kurt Sutter, Ezra Swerdlow Casa di produzioneEscape Artists, Fuqua Films, R...

 

 

Gianni Riso

Questa voce o sezione sugli argomenti musicisti italiani e cantanti italiani non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. Segui i suggerimenti dei progetti di riferimento 1, 2. Gianni RisoGianni Riso (a destra) con un giovanissimo Miguel Bosé Nazionalità Italia GenerePopItalo disco Periodo di attività musicale1980 – 1981 M...

 

 

List of largest galaxies

A Hubble Space Telescope image of the supergiant elliptical galaxy ESO 306-17. Supergiant elliptical galaxies are some of the largest galaxies known. This is a list of largest galaxies known, sorted by order of increasing major axis diameters. The unit of measurement used is the light-year (approximately 9.46×1012 kilometers). Overview The Condor Galaxy is a colossal spiral galaxy disturbed by the smaller IC 4970. It is the largest known spiral galaxy with the isophotal diameter of over 717...

2020年夏季奧林匹克運動會波蘭代表團

2020年夏季奥林匹克运动会波兰代表團波兰国旗IOC編碼POLNOC波蘭奧林匹克委員會網站olimpijski.pl（英文）（波兰文）2020年夏季奥林匹克运动会（東京）2021年7月23日至8月8日（受2019冠状病毒病疫情影响推迟，但仍保留原定名称）運動員206參賽項目24个大项旗手开幕式：帕维尔·科热尼奥夫斯基（游泳）和马娅·沃什乔夫斯卡（自行车）[1]闭幕式：卡罗利娜·纳亚（皮划艇）&#...

 

 

Computed tomography of the abdomen and pelvis

Computed tomography of the abdomen and pelvisCT scan of a normal abdomen and pelvis (Scrollable version is available)ICD-9-CM88.01OPS-301 code3-225-3-226[edit on Wikidata] A CT scan image showing a ruptured abdominal aortic aneurysm. CT Scan of 11 cm Wilms' tumor of right kidney in 13-month-old patient. Computed tomography of the abdomen and pelvis is an application of computed tomography (CT) and is a sensitive method for diagnosis of abdominal diseases. It is used frequently to det...

 

 

Daftar kecamatan dan kelurahan di Kabupaten Kepulauan Sula

Lambang Kabupaten Kepulauan Sula, Provinsi Maluku Utara. Berikut ini adalah daftar kecamatan dan desa di Kabupaten Kepulauan Sula, Provinsi Maluku Utara, Indonesia. Kabupaten Kepulauan Sula terdiri atas 12 kecamatan dan 78 desa dengan luas wilayah 3.304,32 km² dan jumlah penduduk 110.507 jiwa (2017). Kode Wilayah Kabupaten Kepulauan Sula adalah 82.05.[1][2][3][4][5] Kode Wilayah Nama Kecamatan Ibu kota Jumlah Desa Daftar Desa 82.05.01 Mangoli Timu...

Daniel 8

Daniel 8Kitab Daniel lengkap pada Kodeks Leningrad, dibuat tahun 1008.KitabKitab DanielKategoriNabi-nabi BesarBagian Alkitab KristenPerjanjian LamaUrutan dalamKitab Kristen27← pasal 7 pasal 9 → Daniel 8 (disingkat Dan 8) adalah pasal kedelapan Kitab Daniel dalam Alkitab Ibrani dan Perjanjian Lama di Alkitab Kristen. Berisi riwayat Daniel yang berada di Babel pada abad ke-6 SM.[1][2] Teks Pasal ini dibagi atas 27 ayat. Berfokus pada penglihatan yang diterima Daniel ...

 

 

Cuisine of Hawaii

Food and drinks from Hawaii For other uses, see Hawaiian cuisine (disambiguation). Cuisine of HawaiiSome modern Hawaiian dishes. From top left, clockwise: tripe stew (ʻōpū kū), rice (laiki), ʻopihi poke, laulau, squid lūʻau, pipikaula shortribs, kālua puaʻa (kālua pig), and poi in the center.Country or regionHawaiiNational dishSaiminNational drinkMai tai Part of a series on theCulture of Hawaii History People Languages Cuisine Religion Art Literature Music Symbols Flag Coat of arms ...

 

 

Heteresmia spissicornis

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada Februari 2023. Heteresmia spissicornis Klasifikasi ilmiah Kerajaan: Animalia Filum: Arthropoda Kelas: Insecta Ordo: Coleoptera Famili: Cerambycidae Genus: Heteresmia Spesies: Heteresmia spissicornis Heteresmia spissicornis adalah spesies kumbang tanduk panjang yang ...

Thomas A. Burke

American politician (1898–1971) For other people named Thomas Burke, see Thomas Burke (disambiguation). Thomas BurkeBurke in 1954United States Senatorfrom OhioIn officeNovember 10, 1953 – December 2, 1954Appointed byFrank LauschePreceded byRobert A. TaftSucceeded byGeorge H. Bender48th Mayor of ClevelandIn officeJanuary 4, 1945 – December 31, 1953Preceded byFrank LauscheSucceeded byAnthony J. Celebrezze11th President of the United States Conference of MayorsIn office19...

 

 

Government House, Grenada

Official residence of the Governor-General of Grenada in Saint George's For other uses, see Government House. Government HouseGovernment House in 1984General informationTypeOfficial residenceArchitectural styleBritish colonialLocationMount Wheldale, Saint George's, GrenadaCoordinates12°03′12″N 61°44′37″W / 12.05338°N 61.74370°W / 12.05338; -61.74370Completed1780Renovated1886Destroyed2004OwnerGovernment of Grenada Government House is the former official resi...