Sazetidine A

Sazetidine A
Identifiers
  • 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H20N2O2
Molar mass260.337 g·mol−1
3D model (JSmol)
  • OCCCCC#Cc1cc(cnc1)OCC2CCN2
  • InChI=1S/C15H20N2O2/c18-8-4-2-1-3-5-13-9-15(11-16-10-13)19-12-14-6-7-17-14/h9-11,14,17-18H,1-2,4,6-8,12H2/t14-/m0/s1
  • Key:WONBUILDJNKYCB-AWEZNQCLSA-N
  (verify)

Sazetidine A (AMOP-H-OH) is a drug which acts as a subtype selective partial agonist at α4β2 neural nicotinic acetylcholine receptors, acting as an agonist at (α4)2(β2)3 pentamers, but as an antagonist at (α4)3(β2)2 pentamers.[1][2] It has potent analgesic effects in animal studies comparable to those of epibatidine, but with less toxicity,[3] and also has antidepressant action.[4]

References

  1. ^ Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, Kellar KJ (October 2006). "Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them". Molecular Pharmacology. 70 (4): 1454–60. doi:10.1124/mol.106.027318. PMID 16857741. S2CID 6599272.
  2. ^ Zwart R, Carbone AL, Moroni M, Bermudez I, Mogg AJ, Folly EA, et al. (June 2008). "Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors". Molecular Pharmacology. 73 (6): 1838–43. doi:10.1124/mol.108.045104. PMID 18367540. S2CID 24632914.
  3. ^ Cucchiaro G, Xiao Y, Gonzalez-Sulser A, Kellar KJ (September 2008). "Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug". Anesthesiology. 109 (3): 512–9. doi:10.1097/ALN.0b013e3181834490. PMID 18719450. S2CID 22185882.
  4. ^ Kozikowski AP, Eaton JB, Bajjuri KM, Chellappan SK, Chen Y, Karadi S, et al. (August 2009). "Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression". ChemMedChem. 4 (8): 1279–91. doi:10.1002/cmdc.200900079. PMC 2955514. PMID 19569163.

Read other articles:

HTR High Tech Racing

2010 racing video game This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: HTR High Tech Racing – news · newspapers · books · scholar · JSTOR (May 2014) (Learn how and when to remove this template message) 2010 video gameHTR High Tech RacingDeveloper(s)QUByte InteractivePublisher(s)QUByte InteractivePlatform(s)M...

 

The Rose (film)

1979 film by Mark Rydell This article is about the 1979 U.S. film. For other shows, see Rose (disambiguation). The RoseTheatrical release posterDirected byMark RydellScreenplay byBo GoldmanBill KerbyMichael Cimino (uncredited)Story byBill KerbyProduced byAaron RussoMarvin WorthAnthony RayStarringBette MidlerAlan BatesFrederic ForrestCinematographyVilmos ZsigmondEdited byCarroll Timothy O'MearaRobert L. WolfeMusic byPaul A. Rothchild (Mendelssohn – Piano concerto no 1, 2nd movement, the Rose...

 

2021 Durham mayoral election

Durham mayoral election Durham mayoral election, 2021 ← 2019 November 2, 2021 2023 →   Candidate Elaine O'Neal Javiera Caballero Popular vote 25,936 4,463 Percentage 84.6% 14.6% Mayor before election Steve Schewel Elected Mayor Elaine O'Neal Elections in North Carolina Federal government U.S. President 1792 1796 1800 1804 1808 1812 1816 1820 1824 1828 1832 1836 1840 1844 1848 1852 1856 1860 1868 1872 1876 1880 1884 1888 1892 1896 1900 1904 1908 1912 1916 1920 1...

Aloysius Winoto Doeriat

Aloysius Winoto Doeriat (lahir di Yogyakarta,1 Juni 1938) adalah seorang pebinis yang diangkat menjadi presiden direktur pada1990 di PT Inti Indorayon Utama (IIU). Aloysius Winoto Doeriat sempat berkiprah di Institut Pendidikan dan Peminaan Manajemen (IPPM) Jakarta, oleh karena itu dia diangkat menjadi presiden direktur oleh Soekanto Tanoto sang pemilik dari perusahaan terbesar dari kelompok Raja Garuda Mas (RGM). Soekanto Tanoto memilih Aloysius Winoto Doeriat untuk menyelaskan masalah limba...

 

البحرية البلغارية

البحرية البلغارية الدولة بلغاريا  الإنشاء 1879  جزء من القوات المسلحة البلغارية  تعديل مصدري - تعديل   البحرية البلغارية ( (بالبلغارية: Военноморски сили на Република България)‏ ،Voennomorski sili na Republika Bǎlgariya ) هي البحرية التابعة لجمهورية بلغاريا وتشكل جزءًا من القوات ال...

 

Mastodon (social network)

Self-hosted social network software MastodonOriginal author(s)Eugen Rochko[1]Developer(s)Mastodon gGmbH[2]Initial release16 March 2016; 8 years ago (2016-03-16)[3]Stable release4.2.8 / February 23, 2024Preview release4.2.0-rc2 / September 19, 2023; 7 months ago (2023-09-19) Repositorygithub.com/mastodon/mastodon Written inRuby on Rails, JavaScript (React.js, Redux)Operating systemCross-platformPlatformiOS, Android, Linux, BSD, Sailfi...

Perdeli pilav

Perdeli pilav is a Turkish food, typically consisting of rice with chicken, onion and peanuts enveloped in a thin layer of dough, topped with almonds. The pilaf has a shape similar to a cake, and is then served in slices. Curtain pilaf has been registered and geographical indication by the Turkish Patent and Trademark Office. See also Pilaf External links perdeli pilav., TDK Online Dictionary, 2009. perdeli pilav ingredients and preparation. Lezzetler.com, 2009. Perdeli pilav recipe (in Turki...

 

Claudio Sánchez-Albornoz

Excelentísimo Señor DonClaudio Sánchez-AlbornozOCIII OAXSPatung Sánchez-Albornoz di plaza ÁvilaLahirClaudio Sánchez-Albornoz y Menduiña(1893-04-07)7 April 1893Madrid, SpanyolMeninggal8 Juli 1984(1984-07-08) (umur 91)Ávila, SpanyolTanda tangan Claudio Sánchez-Albornoz y Menduiña (pengucapan bahasa Spanyol: [ˈklawðjo ˈsantʃeθ alβoɾˈnoθ]; Madrid, 7 April 1893 – Ávila, 8 Juli 1984) adalah seorang sejarawan abad pertengahan Spanyol terkemuka, negarawan dan Presiden...

 

أحمد المستنصر بالله

  هذه المقالة عن أحمد المستنصر بالله. لمعانٍ أخرى، طالع المستنصر بالله (توضيح). أحمد المستنصر بالله أحمد بن محمد بن أحمد بن الحسن بن يوسف بن محمد بن أحمد بن عبد الله بن محمد بن عبد الله بن أحمد بن إسحاق بن جعفر بن أحمد بن محمد بن جعفر بن محمد بن هارون بن محمد بن عبد الله بن �...

John Reed (novelist)

American novelist For other people with the same name, see John Reed (disambiguation). John ReedReed in 2007Born (1969-02-07) February 7, 1969 (age 55)New York City, U.S.NationalityAmericanAlma materHampshire College (BA)Columbia University (MFA)OccupationNovelistWebsitewww.johnreed.org John Reed (born February 7, 1969) is an American novelist. He is the author of four novels: A Still Small Voice (2000), Snowball's Chance (2002) with a preface by Alexander Cockburn, The Whole (2005)...

 

The Happiness of the Katakuris

2001 film by Takashi Miike The Happiness of the KatakurisTheatrical release posterDirected byTakashi MiikeScreenplay byKikumi Yamagishi[1]Produced by Hirotsugu Yoshida Tetsuo Sasho[1] Starring Kenji Sawada Keiko Matsuzaka Shinji Takeda Naomi Nishida Kiyoshiro Imawano Tetsurō Tamba CinematographyHideo YamamotoEdited byYasushi Shimamura[1]Music by Koji Endo Kouji Makaino[1] ProductioncompanyShochikuRelease dates October 2001 (2001-10) (Tokyo Intern...

 

عائلة كويكبات

رسم بياني يظهر زاوية الميلان المدارية مقارنةً بنصف المحور الرئيسي لعددٍ من الكويكبات. يمكن رؤية عائلات الكويكبات ككتل منفصلة بألوان مختلفة، تقسمها عن بعضها فجوات كيركوُود المعروفة (A, B+C, D, E+F+G). أسر أو عائلات الكويكبات هي تجمُّعات من الكويكبات (أجرام صخرية صغيرة نسبياً) الت�...

White Guard (Finland)

Militia – part of the Finnish Whites movement For other uses, see White Guard. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: White Guard Finland – news · newspapers · books · scholar · JSTOR (July 2007) (Learn how and when to remove this message) Civil GuardSuojeluskunnatSkyddskårBadgeWhite Guard o...

 

7,65 x 53 mm Mauser

7,65 x 53 mm Mauser 7,65 × 53 mm Argentina Tipe Senapan Negara asal Kekaisaran Jerman Sejarah penggunaan Operasional 1889-1970-an Digunakan oleh Lihat Penggunaan Perang Perang Dunia IPerang ChacoPerang Ekuador-PeruPerang Dunia II Sejarah produksi Perancang Paul Mauser Varian 7,65 × 53 mmR (berbingkai) Spesifikasi Jenis selongsong tanpa bingkai, berleher botol Diameter proyektil 7,94 Diameter leher 8,78 Diameter bahu 10,90 Diameter dasar 12,01 Di...

 

Polylactic acid

Biodegradable polymer Polylactic acid Identifiers CAS Number 26100-51-6 ChemSpider None CompTox Dashboard (EPA) DTXSID20904011 Properties Density 1210–1430 kg/m3[1] Melting point 150 to 160 °C (302 to 320 °F; 423 to 433 K)[1] Solubility in water 0 mg/ml [2] Hazards NFPA 704 (fire diamond) 0 1 0 Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references Chemi...

السياحة في كرواتيا

تُعد السياحة في كرواتيا واحدة من أكثر [1] الوجهات السياحية في العالم جاذبية فهي تحتل المركز 18 على مستوى العالم من حيث الشعبية. وتمتاز كرواتيا بتنوع وتعدد منتجعاتها التي تقدم العديد من خدمات العلاج والرفاهية، كما تحتوي على معالم السياحة الجماعية إلى الأسواق المتخصصة وم�...

 

Kolmonen

KolmonenSport Calcio TipoSquadre di club Paese Finlandia Cadenzaannuale Aperturaaprile Chiusuraottobre Partecipanti104 squadre Formula12 gironi all'italiana A/R Promozione inKakkonen Retrocessione inNelonen StoriaFondazione1973 Modifica dati su Wikidata · Manuale La Kolmonen (in italiano Numero tre) è la terza divisione, quarto livello, del campionato finlandese di calcio ed è gestita a livello provinciale. Come tutte le divisioni finlandesi, la terza divisione è giocata dalla p...

 

Poisson bracket

Operation in Hamiltonian mechanics Siméon Denis Poisson Part of a series onClassical mechanics F = d d t ( m v ) {\displaystyle {\textbf {F}}={\frac {d}{dt}}(m{\textbf {v}})} Second law of motion History Timeline Textbooks Branches Applied Celestial Continuum Dynamics Kinematics Kinetics Statics Statistical mechanics Fundamentals Acceleration Angular momentum Couple D'Alembert's principle Energy kinetic potential Force Frame of reference Inertial frame of reference Impulse Inertia / ...

Storia della donna nell'islam

Donna con hijab in Tunisia. La storia della donna nell'Islam è definita tanto dai testi islamici, quanto dalla storia e cultura del mondo musulmano.[1] In base al Corano, il testo sacro islamico, le donne sono uguali agli uomini di fronte ad Allah.[2] La Shari'a (Legge islamica) stabilisce delle differenze tra i ruoli di genere, i diritti e i doveri della donna e dell'uomo. Gli interpreti dei testi giuridici islamici hanno diversi giudizi circa l'interpretazione delle norme r...

 

Monastery

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Monastery – news · newspapers · books · scholar · JSTOR (September 2023) (Learn how and when to remove this message) Complex of buildings comprising the domestic quarters and workplace(s) of monks or nuns The Monastery of Varlaam in Meteora, Thessaly, Greece.A ...