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Satoshi Ōmura
Satoshi Ōmura
大村智
	Satoshi Ōmura, Nobel Laureate in medicine in Stockholm December 2015
Born	12 July 1935 (age 89); Nirasaki, Yamanashi, Japan
Nationality	Japanese
Alma mater	University of Yamanashi (BS); Tokyo University of Science (MS, ScD); University of Tokyo (PhD)
Known for	Avermectin and Ivermectin; Discovery of more than 480 new compounds
Awards	Japan Academy Prize (1990); Koch Gold Medal (1997); Ernest Guenther Award in the Chemistry of Natural Products (2005); Tetrahedron Prize for Creativity in Organic Chemistry (2010); Gairdner Global Health Award (2014); Nobel Prize in Physiology or Medicine (2015)
	Scientific career
Fields	Biochemistry
Institutions	Kitasato University; Wesleyan University
Academic advisors	Koji Nakanishi; Max Tishler

Satoshi Ōmura (大村智, Ōmura Satoshi, [oːmɯɾa saꜜtoɕi]; born 12 July 1935) is a Japanese biochemist. He is known for the discovery and development of hundreds of pharmaceuticals originally occurring in microorganisms. In 2015, he was awarded the Nobel Prize in Physiology or Medicine jointly with William C. Campbell for their role in the discovery of avermectins and ivermectin.^[1] the world's first endectocide and a safe and highly effective microfilaricide.^[2] It is believed that the large molecular size of ivermectin prevents it from crossing the blood/aqueous humour barrier, and renders the drug an important treatment of helminthically-derived blindness.

Early life and education

Satoshi Ōmura was born in Nirasaki, Yamanashi Japan in 1935, the second son of Ōmura family. After graduating from the University of Yamanashi in 1958, he was appointed to science teacher at Tokyo Metropolitan Sumida Tech High School. In 1960, he became an auditor of Koji Nakanishi’s course at Tokyo University of Education, one year later, he enrolled in the Tokyo University of Science (TUS) and studied sciences. Ōmura received his M.S. degree from TUS and his Ph.D. in Pharmaceutical Sciences from the University of Tokyo (1968, a Dissertation PhD) and a Ph.D. in Chemistry at TUS (1970).^[3]

Career

Since 1965 Ōmura served at Kitasato Institute system.^[4] From 1970 to 1990, he also became a part-time lecturer at Tokyo University of Science.^[5]

In 1971 while he was a visiting professor at Wesleyan University,^[4] he consulted the chairman of the American Chemical Society, Max Tishler, at an international conference. Together they successfully acquired research expenses from Merck & Co.^[6] Ōmura was considering continuing his research in the United States, but ultimately he decided to return to Japan.

In 1973, he became a director of the antibiotic laboratory at Kitasato University,^[7] and he also started collaborative research with Merck & Co.^[8]

In 1975, he became professor of Kitasato University School of Pharmacy. Meanwhile, the Ōmura laboratory raised many researchers and produced 31 university professors and 120 doctors.

At present date, Ōmura is professor emeritus at Kitasato University and Max Tishler Professor of Chemistry at Wesleyan University.

Research

Satoshi Ōmura is known for the discovery and development of various pharmaceuticals originally occurring in microorganisms. He was awarded the 2015 Nobel Prize in Physiology or Medicine jointly with William C. Campbell for discoveries concerning a novel therapy against infections caused by roundworm parasites. More precisely, his research group isolated a strain of Streptomyces avermitilis that produce the anti-parasitical compound avermectin.^[2] Campbell later acquired these bacteria and developed the derived drug ivermectin that was first commercialised for veterinary use in 1981 later put to human use against Onchocerciasis in 1987–88 with the name Mectizan,^[2] and is today used against river blindness, lymphatic filariasis, scabies, other parasitic infections.^[3]^[9]^[10]

Since the 1970s, Ōmura has discovered more than 480 new compounds, of which 25 kinds of drugs and reagents are in use. Examples include andrastin, herbimycin, neoxaline as well as:

a specific inhibitor of protein kinase named staurosporine;
a proteasome inhibitor named lactacystin;
a fatty acid biosynthesis inhibitor named cerulenin;

Furthermore, compounds having a unique structure and biological activity discovered by Omura are drawing attention in drug discovery research, and new anticancer drugs and the like have been created.

Selected publications

Satoshi Ōmura; Y Iwai; A Hirano; A Nakagawa; J Awaya; H Tsuchya; Y Takahashi; R Masuma (April 1977). "A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization". The Journal of Antibiotics. 30 (4): 275–82. doi:10.7164/ANTIBIOTICS.30.275. ISSN 0021-8820. PMID 863788. Wikidata Q28279608.
R. W. Burg; B. M. Miller; E. E. Baker; et al. (March 1979). "Avermectins, new family of potent anthelmintic agents: producing organism and fermentation". Antimicrobial Agents and Chemotherapy. 15 (3): 361–7. doi:10.1128/AAC.15.3.361. ISSN 0066-4804. PMC 352666. PMID 464561. Wikidata Q24598202.
D A Hopwood; F Malpartida; H M Kieser; et al. (1 April 1985). "Production of 'hybrid' antibiotics by genetic engineering". Nature. 314 (6012): 642–644. doi:10.1038/314642A0. ISSN 1476-4687. PMID 3857464. Wikidata Q59071761.
H Ikeda; T Nonomiya; M Usami; T Ohta; Satoshi Ōmura (1 August 1999). "Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis". Proceedings of the National Academy of Sciences of the United States of America. 96 (17): 9509–9514. Bibcode:1999PNAS...96.9509I. doi:10.1073/PNAS.96.17.9509. ISSN 0027-8424. PMC 22239. PMID 10449723. Wikidata Q33871234.
Masahiko Hayashi; Mun-Chual Rho; Akiko Enomoto; et al. (4 November 2002). "Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130". Proceedings of the National Academy of Sciences of the United States of America. 99 (23): 14728–14733. Bibcode:2002PNAS...9914728H. doi:10.1073/PNAS.232562799. ISSN 0027-8424. PMC 137487. PMID 12417753. Wikidata Q34379185.
Tomoyasu Hirose; Toshiaki Sunazuka; Satoshi Omura (1 January 2010). "Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms". Proceedings of the Japan Academy, Series B. 86 (2): 85–102. doi:10.2183/PJAB.86.85. ISSN 0386-2208. PMC 3417560. PMID 20154467. Wikidata Q34098670.
Nobuyuki Matoba; Adam S Husk; Brian W Barnett; et al. (2010). "HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activity". PLOS One. 5 (6): e11143. Bibcode:2010PLoSO...511143M. doi:10.1371/JOURNAL.PONE.0011143. ISSN 1932-6203. PMC 2886112. PMID 20559567. Wikidata Q21076115.
Hirofumi Nakano; Satoshi Omura (9 January 2009). "Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine". The Journal of Antibiotics. 62 (1): 17–26. doi:10.1038/JA.2008.4. ISSN 0021-8820. PMID 19132059. Wikidata Q34918248.
Ōmura, S. (2011). "Microbial metabolites: 45 years of wandering, wondering and discovering". Tetrahedron. 67 (35): 6420–6459. doi:10.1016/j.tet.2011.03.117.

Social role

Ōmura served as deputy director and director at the Kitasato Institute. He was devoted to rebuild the laboratory and promoting the establishment of the medical center that is now Kitasato University Medical Center. Meanwhile, he established a path to rebuilding of the corporate school juridical person, which has integrated with the School corporation Kitasato Gakuen. He succeeded in establishing a new "School corporation Kitasato Institute". In addition, he served as president of the School corporation Joshibi University of Art and Design twice, and served as the honorary school chief of the School corporation Kaichi Gakuen.^[11] In 2007, he established the Nirasaki Omura Art Museum on his collection.^[12]

Awards and honors

A Children's statues leading to adults of onchocerciasis before Kitasato University buildings were produced by sculptors of Burkina Faso in honor of Ōmura's contributions of avermectin and ivermectin, a symbol of the campaign to eradicate onchocerciasis.^{[clarification needed]}^[13] Similar life-sized bronze statues were erected in World Health Organization (WHO) Headquarters,^[where?] Carter Center, Merck & Co., World Bank Headquarters, and Burkina Faso's World Health Organization Africa Onchocerciasis Control Program.^{[clarification needed]}

1985 – Hoechst-Roussel Award^[14]
1986 – The Pharmaceutical Society of Japan Award^[14]
1988 – Uehara Prize^[14]
1990 – Japan Academy Prize (academics)^[14]
1992 – Medal with Purple Ribbon^[14]
1995 – Fujihara Award^[14]
1997 – Robert Koch Gold Medal^[15]
1998 – Prince Mahidol Award^[14]
2000 – Nakanishi Prize (American Chemical Society and Chemical Society of Japan)^[14]
2005 – Ernest Guenther Award in the Chemistry of Natural Products (American Chemical Society)^[14]
2007 – Hamao Umezawa Memorial Award^[14]
2008 – Knight of the Legion of Honour of France
2010 – Tetrahedron Prize for Creativity in Organic Chemistry^[14]
2011 – Arima Award^[14]
2011 – Order of the Sacred Treasure, Gold and Silver Star^[16]
2012 – Person of Cultural Merit^[14]
2014 – Canada Gairdner Global Health Award^[17]
2015 – Asahi Prize^[14]
2015 – The Order of Cultural Merit^[14]
2015 – Nobel Prize in Physiology or Medicine
2016 – Japan Bioindustry Association (JBA) Special Honorary Award
2016 – Society for Actinomycetes Japan (SAJ) Special Honorary Award

Honorary doctorates

List of honorary doctorates:^[18]

1992 – Lajos Kossuth University, Hungary
1994 – Wesleyan University, USA
2016 – Shanghai Jiao Tong University, China
2018 – University of St Andrews, Scotland

Learned societies membership

1992 – Academy of Sciences Leopoldina^[19]
1999 – National Academy of Sciences^[20]
2001 – Japan Academy^[21]
2002 – Académie des sciences^[22]
2005 – Russian Academy of Sciences
2005 – Royal Society of Chemistry
2005 – Academia Europaea
2006 – Chinese Academy of Engineering
2009 – Japan Society for Bioscience, Biotechnology and Agrochemistry
2014 – Pharmaceutical Society of Japan [ja]
2016 – Japan Pharmaceutical Association
2016 – Japan Society of Synthetic Organic Chemistry
2016 – Japan Society of Chemotherapy

References

^ "The Nobel Prize in Physiology or Medicine 2015". Nobel Prize Outreach AB. 6 October 2015. Archived from the original on 9 February 2021. Retrieved 12 October 2020.
^ ^a ^b ^c Andy Crump; Satoshi Ōmura (1 January 2011). "Ivermectin, 'wonder drug' from Japan: the human use perspective". Proceedings of the Japan Academy, Series B. 87 (2): 13–28. Bibcode:2011PJAB...87...13C. doi:10.2183/PJAB.87.13. ISSN 0386-2208. PMC 3043740. PMID 21321478. Wikidata Q34598257.
^ ^a ^b "Satoshi Omura PhD". Archived from the original on 7 October 2015. Retrieved 5 October 2015.
^ ^a ^b 大村智北里研究所顧問・北里大学名誉教授が文化功労者に Archived 2016-03-04 at the Wayback Machine 北里大学 2012年11月1日
^ [from ストックホルム]「これからは人材の育成に努力します」大村先生が語った受賞後の活動 Archived 2016-12-23 at the Wayback Machine TUSToday 2015.12.18
^ 「人間発見」日本経済新聞2010年7月14日
^ 「【ノーベル賞受賞】大村智氏、常識破りの発想で治療薬開発」 Archived 2019-05-03 at the Wayback Machine 産経ニュース2015.10.5
^ 「新しい微生物創薬の世界を切り開く」 Archived 2015-11-10 at the Wayback Machine JT
^ Press release Archived 2021-02-09 at the Wayback Machine NobelPrize.org
^ "Japanese microbiologist Satoshi Omura shares Nobel Prize for medicine". The Japan Times. 5 October 2015. Archived from the original on 21 October 2017. Retrieved 5 October 2015.
^ "大村先生". 開智学園高等部. Archived from the original on 2015-10-09. Retrieved 2015-10-12.
^ "韮崎大村美術館館長あいさつ大村智". 韮崎大村美術館. Archived from the original on 2015-10-15. Retrieved 2015-10-12.
^ "『新しい微生物創薬の世界を切り開く』大村智". サイエンティスト・ライブラリー | JT生命誌研究館. Archived from the original on 12 July 2024. Retrieved 14 March 2022.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o Satoshi Ōmura. "Satoshi Ōmura Curriculum Vitae" (PDF). Archived (PDF) from the original on 2015-10-06. Retrieved 2015-10-06.
^ "Robert Koch Gold Medal". Robert-Koch-Stiftung e.V. Archived from the original on 2018-03-09. Retrieved 2015-10-05.
^ 【政府】11年「春の叙勲」‐森田氏に旭重、大村氏が瑞重 Archived 2014-03-27 at the Wayback Machine 薬事日報 2011年6月20日
^ "Satoshi Ōmura". Archived from the original on 28 February 2022. Retrieved 14 March 2022.
^ "CURRICULUM VITAE" (PDF). satoshi-omura.info. March 2019. Archived (PDF) from the original on 8 April 2023. Retrieved 12 July 2024.
^ "List of Members | Prof. Dr. Dr. Satoshi Ōmura". Retrieved 14 March 2022.
^ "Satoshi Omura". www.nasonline.org. Archived from the original on 23 January 2022. Retrieved 14 March 2022.
^ "Personal Information – ŌMURA Satoshi | The Japan Academy". www.japan-acad.go.jp. Archived from the original on 14 March 2022. Retrieved 14 March 2022.
^ "Satoshi Omura | Liste des membres de l'Académie des sciences / O | Listes par ordre alphabétique | Listes des membres | Membres | Nous connaître". www.academie-sciences.fr. Archived from the original on 27 September 2020. Retrieved 14 March 2022.

External links

Professor Satoshi Omura
Satoshi Ōmura | People | THE KITASATO INSTITUTE
Nirasaki Omura Art Museum
Satoshi Ōmura Quotes With Pictures
Satoshi Ōmura on Nobelprize.org

[npoab-1] "The Nobel Prize in Physiology or Medicine 2015". Nobel Prize Outreach AB. 6 October 2015. Archived from the original on 9 February 2021. Retrieved 12 October 2020.

[omura11-2] Andy Crump; Satoshi Ōmura (1 January 2011). "Ivermectin, 'wonder drug' from Japan: the human use perspective". Proceedings of the Japan Academy, Series B. 87 (2): 13–28. Bibcode:2011PJAB...87...13C. doi:10.2183/PJAB.87.13. ISSN 0386-2208. PMC 3043740. PMID 21321478. Wikidata Q34598257.

[Gairdner-3] "Satoshi Omura PhD". Archived from the original on 7 October 2015. Retrieved 5 October 2015.

[kitasato2012-4] 大村智北里研究所顧問・北里大学名誉教授が文化功労者に Archived 2016-03-04 at the Wayback Machine 北里大学 2012年11月1日

[5] [from ストックホルム]「これからは人材の育成に努力します」大村先生が語った受賞後の活動 Archived 2016-12-23 at the Wayback Machine TUSToday 2015.12.18

[hakken-6] 「人間発見」日本経済新聞2010年7月14日

[7] 「【ノーベル賞受賞】大村智氏、常識破りの発想で治療薬開発」 Archived 2019-05-03 at the Wayback Machine 産経ニュース2015.10.5

[JT-BRH-SCIENTISTWEB-8] 「新しい微生物創薬の世界を切り開く」 Archived 2015-11-10 at the Wayback Machine JT

[Nobelprize-9] Press release Archived 2021-02-09 at the Wayback Machine NobelPrize.org

[10] "Japanese microbiologist Satoshi Omura shares Nobel Prize for medicine". The Japan Times. 5 October 2015. Archived from the original on 21 October 2017. Retrieved 5 October 2015.

[11] "大村先生". 開智学園高等部. Archived from the original on 2015-10-09. Retrieved 2015-10-12.

[12] "韮崎大村美術館館長あいさつ大村智". 韮崎大村美術館. Archived from the original on 2015-10-15. Retrieved 2015-10-12.

[13] "『新しい微生物創薬の世界を切り開く』大村智". サイエンティスト・ライブラリー | JT生命誌研究館. Archived from the original on 12 July 2024. Retrieved 14 March 2022.

[CV-14] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o Satoshi Ōmura. "Satoshi Ōmura Curriculum Vitae" (PDF). Archived (PDF) from the original on 2015-10-06. Retrieved 2015-10-06.

[15] "Robert Koch Gold Medal". Robert-Koch-Stiftung e.V. Archived from the original on 2018-03-09. Retrieved 2015-10-05.

[16] 【政府】11年「春の叙勲」‐森田氏に旭重、大村氏が瑞重 Archived 2014-03-27 at the Wayback Machine 薬事日報 2011年6月20日

[17] "Satoshi Ōmura". Archived from the original on 28 February 2022. Retrieved 14 March 2022.

[18] "CURRICULUM VITAE" (PDF). satoshi-omura.info. March 2019. Archived (PDF) from the original on 8 April 2023. Retrieved 12 July 2024.

[19] "List of Members | Prof. Dr. Dr. Satoshi Ōmura". Retrieved 14 March 2022.

[20] "Satoshi Omura". www.nasonline.org. Archived from the original on 23 January 2022. Retrieved 14 March 2022.

[21] "Personal Information – ŌMURA Satoshi | The Japan Academy". www.japan-acad.go.jp. Archived from the original on 14 March 2022. Retrieved 14 March 2022.

[22] "Satoshi Omura | Liste des membres de l'Académie des sciences / O | Listes par ordre alphabétique | Listes des membres | Membres | Nous connaître". www.academie-sciences.fr. Archived from the original on 27 September 2020. Retrieved 14 March 2022.

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PROFILPELAJAR.COM

Satoshi Ōmura

Early life and education

Career

Research

Selected publications

Social role

Awards and honors

Honorary doctorates

Learned societies membership

See also

References

External links

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