Onchocerciasis

"Elephant skin" redirects here. For the type of Precambrian and Cambrian seabed found fossil, see Matground.
Onchocerciasis
Other namesRiver blindness, Robles disease
An adult black fly with the parasite Onchocerca volvulus coming out of the insect's antenna, magnified 100×
Pronunciation
SpecialtyInfectious disease
SymptomsItching, bumps under the skin, blindness[1]
CausesOnchocerca volvulus spread by a black fly[1]
PreventionAvoiding bites (insect repellent, proper clothing)[2]
MedicationIvermectin, doxycycline[3][4]
Frequency15.5 million (2015)[5]

Onchocerciasis, also known as river blindness, is a disease caused by infection with the parasitic worm Onchocerca volvulus.[1] Symptoms include severe itching, bumps under the skin, and blindness.[1] It is the second-most common cause of blindness due to infection, after trachoma.[6]

The parasitic worm is spread by the bites of a black fly of the Simulium genus.[1] Usually, many bites are required before infection occurs.[7] These flies live near rivers, hence the common name of the disease.[6] Once inside a person, the worms create larvae that make their way out to the skin, where they can infect the next black fly that bites the person.[1] There are a number of ways to make the diagnosis, including placing a biopsy of the skin in normal saline and watching for the larva to come out, looking in the eye for larvae, and looking within the bumps under the skin for adult worms.[8]

A vaccine against the disease does not exist.[1] Prevention is by avoiding being bitten by flies.[2] This may include the use of insect repellent and proper clothing.[2] Other efforts include those to decrease the fly population by spraying insecticides.[1] Efforts to eradicate the disease by treating entire groups of people twice a year are ongoing in a number of areas of the world.[1] Treatment of those infected is with the medication ivermectin every six to twelve months.[1][3] This treatment kills the larvae but not the adult worms.[4] The antibiotic doxycycline weakens the worms by killing an associated bacterium, Wolbachia, and is recommended by some as well.[4] The lumps under the skin may also be removed by surgery.[3]

According to the Centers for Disease Control and Prevention, as of 2017, about 20.9 million people were infected with onchocerciasis, and an estimated 1.15 million have some vision loss from the infection.[7] Most infections occur in sub-Saharan Africa, although cases have also been reported in Yemen and isolated areas of Central and South America.[1] In 1915, the physician Rodolfo Robles first linked the worm to eye disease.[9] It is listed by the World Health Organization (WHO) as a neglected tropical disease.[10] In 2013 Colombia became the first country to eradicate the disease.[10]

Cause

Onchocerciasis is a parasitic infection caused by the roundworm species Onchocerca volvulus. The larvae of O. volvulus enter a human host when an infected female adult fly from the genus Simulium bites them. After that, it can take up to three months for the worms to mature under the skin of their host.[11] The worms mainly get nutrients for growth in humans from blood, but they have also been seen to rely on other bodily fluids such as cerebrospinal fluid, and urine.[11] It is common to see nodules formed in the skin where the adult worms reside and mate. However, these worms will often travel throughout the body using blood vessels in connective tissues and even settle behind the cornea.[12]

Life cycle

The life of the parasite can be traced through the black fly and the human hosts in the following steps:[13][14]

  1. A Simulium female black fly takes a blood meal on an infected human host and ingests microfilaria.
  2. The microfilaria enter the black fly's gut and thoracic flight muscles, progressing into the first larval stage (J1.).
  3. The larvae mature into the second larval stage (J2.) and move to the proboscis and into the saliva in its third larval stage (J3.). Maturation takes about seven days.
  4. The black fly takes another blood meal, passing the larvae into the next human host's blood.
  5. The larvae migrate to the subcutaneous tissue and undergo two more molts. They form nodules as they mature into adult worms over six to 12 months.
  6. After maturing, adult male worms mate with female worms in the subcutaneous tissue to produce between 700 and 1,500 microfilariae daily.
  7. The microfilaria migrate to the skin during the day, and the black flies only feed during the day, so the parasite is in a prime position for the female fly to ingest it. Black flies take blood meals to ingest these microfilaria to restart the cycle.

Signs and symptoms

The larvae can move through the body without triggering a response from the host's immune system, so some people who are infected with the parasite experience no symptoms; the Global Burden of Disease Study estimated that in 2017 there were at least 20.9 million people infected worldwide, of which 14.6 million had skin disease symptoms and 1.15 million experienced symptoms that impacted vision.[15] After a blackfly bite, it can take 12–18 months for the larvae to develop into mature adult worms that will produce their larvae, which is what leads to the development of symptoms.[16] Almost all the clinical manifestations of onchocerciasis are due to localized host inflammatory responses to dead or dying microfilariae (larvae).[17] The signs and symptoms of onchocerciasis are usually divided into two categories, skin and eye symptoms.

Skin symptoms will develop years before any vision problems.[citation needed] These symptoms include:[18]

  • Intense itching
  • Swelling
  • Inflammation
  • Depigmentation
  • Hyperpigmentation
  • Rash
  • Nodules under the skin
  • Skin atrophy
  • Hanging groin (folds of inelastic atrophic skin in the groin associated with enlarged lymph nodes)

Eye symptoms include:[19]

  • Vision impairment, low vision, or permanent blindness.
  • Clouding of the cornea
  • Light sensitivity
  • Lesions on eyes
  • Glaucoma
  • Eye pain
  • Eye redness

Eye symptoms provide the common name associated with onchocerciasis, river blindness, and may involve any part of the eye from conjunctiva and cornea to uvea and posterior segment, including the retina and optic nerve.[20][21] The microfilariae migrate to the surface of the cornea. Punctate keratitis occurs in the infected area. This clears up as the inflammation subsides.[citation needed] However, if the infection is chronic, sclerosing keratitis can occur, making the affected area become opaque. Over time, the entire cornea may become opaque, thus leading to blindness. Some evidence suggests an immune response to bacteria present in the worms causes the effect on the cornea.[20]

Mazzotti reaction

Main article: Mazzotti reaction

The Mazzotti reaction, first described in 1948, is a symptom complex seen in patients after undergoing treatment of onchocerciasis with the medication diethylcarbamazine (DEC). Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and abdominal pain that occur within seven days of treatment of microfilariasis.[22]

Patch test

The phenomenon is so common when DEC is used that this drug is the basis of a skin patch test used to confirm that diagnosis. The drug patch is placed on the skin, and if the patient is infected with O. volvulus microfilaria, localized pruritus and urticaria are seen at the application site.[23]

Nodding disease

Main article: Nodding disease

This is an unusual form of epidemic epilepsy associated with onchocerciasis although a definitive link has not been established. This syndrome was first described in Tanzania by Louise Jilek-Aall, a Norwegian psychiatric doctor in Tanzanian practice, during the 1960s. It occurs most commonly in Uganda and South Sudan. It manifests itself in previously healthy 5–15-year-old children, is often triggered by eating or low temperatures, and is accompanied by cognitive impairment. Seizures occur frequently and may be difficult to control. The electroencephalogram is abnormal but cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) are normal or show non-specific changes. If there are abnormalities on the MRI, they are usually present in the hippocampus.[24]

Diagnosis

When a clinical diagnosis of onchocerciasis is obtained, doctors take small snips of skin containing 3–5 mg of skin tissue.[11] The skin samples taken are only from the upper dermis.[25] These samples will then be soaked in saline and examined underneath a microscope to check for the presence of microfilaria. If microfilariae are not detected in the samples, the Mazzotti test is used. In this test, 6 mg of diethylcarbamazine is administered to the affected area. If the patient experiences intense inflammation or itching in the affected area Microfilaria is present.[11] Slit-lamp eye exams are used to identify signs of the parasites in and around the eyes of patients whose eyes are affected. Antibody tests when available can aid in the diagnosis of Onchocerciasis.[citation needed]

Classification

Onchocerciasis causes different kinds of skin changes, which vary in different geographic regions; it may be divided into the following phases or types:[26]: 440–441 [verification needed]

Erisipela de la costa
An acute phase, it is characterized by swelling of the face, with erythema and itching.[26]: 440  This skin change, erisípela de la costa, of acute onchocerciasis is most commonly seen among victims in Central and South America.[27]
Mal morando
This cutaneous condition is characterized by inflammation accompanied by hyperpigmentation.[26]: 440 
Sowda
A cutaneous condition, it is a localized type of onchocerciasis.[26]: 440 

Additionally, the various skin changes associated with onchocerciasis may be described as follows:[26]: 440 

Leopard skin
The spotted depigmentation of the skin that may occur with onchocerciasis[26]: 440 
Elephant skin
The thickening of human skin that may be associated with onchocerciasis[26]: 440 
Lizard skin
The thickened, wrinkled skin changes that may result with onchocerciasis[26]: 441 

Prevention

Various control programs aim to stop onchocerciasis from being a public health problem.[28] The Onchocerciasis Control Programme (OCP) launched in 1974, and at its peak, covered 30 million people in the following countries: Benin, Burkina Faso, Côte d'Ivoire, Ghana, Togo, Mali, and Niger. The OCP utilized the following initiatives: the use of larvicide spraying into fast-flowing rivers to control black fly populations, and from 1988 onwards, the use of ivermectin to treat infected people as a core treatment therapy. Alongside the OCP, a joint effort of the World Health Organization, the World Bank, the United Nations Development Programme, and the UN Food and Agriculture Organization, was considered to be a success in controlling onchocerciasis, and in 2002 shifted from control of onchocerciasis to elimination. According to the World Health Organization, four countries have eradicated onchocerciasis: Colombia (2013), Ecuador (2014), Mexico (2015), and Guatemala (2016). Continued monitoring ensures onchocerciasis cannot reinvade the area through the OCP.[29] Other effective prevention efforts include personal protection from black fly bites. Recommended protection measures from the CDC include using insect repellents and wearing long sleeves and pants to eliminate exposed skin. Using insect repellent that contains N,N-Diethyl-meta-toluamide (DEET) as well as clothing treated with permethrin.[30]

Elimination

In 1995, the African Programme for Onchocerciasis Control (APOC) was initiated to eliminate onchocerciasis in African countries where the disease was endemic.[31] The initiative relied primarily on the use of the antiparasitic drug ivermectin. The initiative was to set up community-directed treatment with ivermectin for those at risk of infection. Overall transmission has declined.[32] The APOC ended in 2015 and aspects of its work has been taken over by the WHO Expanded Special Programme for the Elimination of Neglected Tropical Diseases (ESPEN). As in the Americas, the objective of ESPEN has been to work with Government Health Ministries and partner non-governmental organizations, to eliminate the transmission of onchocerciasis. This requires consistent annual treatment of 80% of the population in endemic areas for at least 10–12 years, the life span of the adult worm. No African country has verified the elimination of onchocerciasis. Treatment has stopped in some areas (e.g. Nigeria), following epidemiological and entomological assessments that demonstrated no ongoing transmission could be detected.[33]

The Onchocerciasis Elimination Programme for the Americas (OEPA) was launched in 1992.[34] On July 29, 2013, the Pan American Health Organization (PAHO) announced that after 16 years of efforts, Colombia had become the first country in the world to eliminate onchocerciasis.[35] Countries that received verification of elimination were Colombia in 2013, Ecuador in 2015, and Guatemala in 2016.[36] The key factor in elimination was mass administration of ivermectin. The OEPA projection was that the disease would be eliminated from all remaining countries in the Americas by 2012.[37] In September 2015, the OEPA announced that onchocerciasis only remained in a remote region on the border of Brazil and Venezuela.[38] The area is home to the Yanomami indigenous people.

No vaccine to prevent onchocerciasis infection in humans is available. This is due to two potential target product profiles (TPPs) that must be considered when developing a vaccine for onchocerciasis, making vaccine development difficult.[39] The project to develop a vaccine for the disease has two goals. The first priority is a preventive vaccine for children five years or younger, as this population does not receive ivermectin. The second is a therapeutic vaccine to target adult worms, microfilariae, and the causative agents of pathology and transmission, or both, for children and adults with O. volvulus infection.[40]

Treatment

The burden of onchocerciasis: children leading blind adults in Africa

In mass drug administration (MDA) programmes, the treatment for onchocerciasis is ivermectin (trade name: Mectizan). Ivermectin is administered four times a year and will be continually administered for 10–14 years due to the lifespan of the adult worm.[25] Intense skin itching is eventually relieved, and the progression towards blindness is halted. The drug reduces larval release from the adult worm but does not kill it.[11] However the drug does not prevent transmission of Onchocerciasis.[41] It however reduces morbidity and has shown promising results to eliminate in some endemic areas of Africa[42]

Ivermectin treatment is particularly effective because it only needs to be taken once or twice a year, needs no refrigeration, and has a wide margin of safety, with the result that it has been widely given by minimally trained community health workers.[43] Patients taking the drug for the treatment of onchocerciasis may have adverse effects within 1–2 days after the drug is administered. Symptoms include urticaria, pruritus, fever, dermatitis, myalgia, swelling of the face and limbs, or postural hypotension.[25]

Antibiotics

For the treatment of individuals, doxycycline is used to kill the Wolbachia bacteria that live in adult worms. This adjunct therapy has been shown to significantly lower microfilarial loads in the host and may kill the adult worms, due to the symbiotic relationship between Wolbachia and the worm.[44][45][46] In four separate trials over ten years with various dosing regimens of doxycycline for individualized treatment, doxycycline was found to be effective in sterilizing the female worms and reducing their numbers over four to six weeks. Research on other antibiotics, such as rifampicin, has shown it to be effective in animal models at reducing Wolbachia both as an alternative and as an adjunct to doxycycline.[47] However, doxycycline treatment requires daily dosing for at least four to six weeks, making it more difficult to administer in the affected areas.[43]

Ivermectin

Ivermectin kills the parasite by interfering with the nervous system and muscle function, in particular, by enhancing inhibitory neurotransmission. The drug binds to and activates glutamate-gated chloride channels.[43] These channels, present in neurons and myocytes, are not invertebrate-specific, but are protected in vertebrates from the action of ivermectin by the blood–brain barrier.[43] Ivermectin is thought to irreversibly activate these channel receptors in the worm, eventually causing an inhibitory postsynaptic potential. The chance of a future action potential occurring in synapses between neurons decreases and the nematodes experience flaccid paralysis followed by death.[48][49][50]

Ivermectin is directly effective against the larval stage microfilariae of O. volvulus; they are paralyzed and can be killed by eosinophils and macrophages. It does not kill adult females (macrofilariae) but does cause them to cease releasing microfilariae, perhaps by paralyzing the reproductive tract.[43] Ivermectin is very effective in reducing microfilarial load and reducing number of punctate opacities in individuals with onchocerciasis.[51]

Moxidectin

After two decades of research, moxidectin was approved by the U.S. Food and Drug Administration in 2018 for use in ages 12 and older. Ongoing studies are looking to identify doses that will be safe for children ages 4–11.[52] The oral dosage for moxidectin in adults and children 12 and up is 8 mg in a single dose.[53] Moxidectin has been found to more strongly suppress the O. volvulus microfilariae for longer than ivermectin treatments, with peak clearance of microfilariae in the skin at one month after treatment. After six months post-treatment, many individuals treated with moxidectin have no detectable microfilariae in their skin.[54]

Epidemiology

Disability-adjusted life year for onchocerciasis per 100,000 inhabitants
  not endemic
  less than 10
  10–50
  50–60
  60–70
  70–80
  80–90
  90–100
  100–150
  150–200
  200–300
  300–400
  >400

About 21 million people were infected with this parasite in 2017; about 1.2 million of those had vision loss.[55] As of 2017, about 99% of onchocerciasis cases occurred in Africa.[55] Onchocerciasis is currently relatively common in 31 African countries, Yemen, and isolated regions of South America.[56] Over 85 million people live in endemic areas, and half of these reside in Nigeria. Another 120 million people are at risk for contracting the disease. The Onchocerca volvulus main habitat is fast-flowing rivers, Onchocerciasis is more commonly found along the large rivers in northern and central regions of Africa, with cases decreasing with distance from the rivers.[citation needed] Multiple exposures to Simulium blackflies raise the number of adult worms and microfilariae that are present in the host.[citation needed] Risk of contracting Onchocerciasis for casual travelers is low, since it often takes several exposures, while travelers that stay for longer visits such as missionaries or long-term volunteers have a greater risk of contracting Onchocerciasis.[citation needed] Onchocerciasis was eliminated in the northern focus in Chiapas, Mexico,[57] and the focus in Oaxaca, Mexico, where Onchocerca volvulus existed, was determined, after several years of treatment with ivermectin, as free of the transmission of the parasite.[58] In April 2013, Colombia became the first country to achieve elimination of Onchocerciasis, verified by the World Health Organization. In the following three years, Ecuador, Guatemala, and Mexico eliminated Onchocerciasis with ivermectin.[59]

Cities in Nigeria, Cameroon, Ethiopia, Uganda, and the Congo have had the largest amounts of infected individuals.[11]

The efforts of CDTI (Community-Directed Treatment with Ivermectin) were conducted to study Onchocerciasis associations with epilepsy. The results do not go unnoticed as they decreased the number of microfilariae (larvae) loads. This was able to decrease the number of blind people due to onchocerciasis dramatically. However, another issue that arises is the fact that onchocerciasis can cause epilepsy, most likely because the level of microfilariae load required to develop epilepsy is much lower than to develop blindness.[60]

According to a 2002 WHO report, onchocerciasis has not caused a single death, but its global burden is 987,000 disability adjusted life years (DALYs). The severe itchiness alone accounts for 60% of the DALYs. Infection reduces the host's immunity and resistance to other diseases, which results in an estimated reduction in life expectancy of 13 years.[56] In 2017, the Global Burden of Disease study said that an estimated 220 million people needed preventive chemotherapy for onchocerciasis. Of those infected, 14.6 million had skin disease, and 1.15 million experienced vision loss.[61]

Onchocerciasis is the second leading cause of blindness from infectious causes. Main disease symptoms, such as blindness and itching, contribute to disease burden by limiting the infected individuals' ability to live and work. Individuals most at risk live or work in areas where Simulium blackflies are most common, mostly near rivers and streams. Rural agricultural areas in sub-Saharan Africa see the most disease burden by blackfly bites.[62] Onchocerciasis common to tropical environments, like that of sub-Saharan Africa, where more than 99% percent of infected individuals occupy the 31 countries.[61] Onchocerciasis can be linked to impoverished remote areas, as residents who experience symptoms can no longer tend to land or navigate the area.[63] Areas with high infection rates may experience up to one-third of residents affected by onchocerciasis symptoms.[63] The age group most impacted by the disease are individuals age 61+ years.[64]

History

Onchocerca originated in Africa and was exported to the Americas by the slave trade, as part of the Columbian exchange that introduced other old-world diseases such as yellow fever into the New World. The findings of a phylogenetic study in the mid-90s are consistent with an introduction to the New World in this manner. DNA sequences of savannah and rainforest strains in Africa differ, while American strains are identical to savannah strains in western Africa.[65] The microfilarial parasite that causes the disease was first identified in 1874 by an Irish naval surgeon, John O'Neill, who sought to identify the cause of a common skin disease along the west coast of Africa, known as "craw-craw".[66] Rudolf Leuckart, a German zoologist, later examined specimens of the same filarial worm sent from Africa by a German missionary doctor in 1890 and named the organism Filaria volvulus.[67]

Rodolfo Robles and Rafael Pacheco in Guatemala first mentioned the ocular form of the disease in the Americas in about 1915. They described a tropical worm infection with adult Onchocerca that included inflammation of the skin, especially the face ('erisipela de la costa'), and eyes.[68] The disease, commonly called the "filarial blinding disease", and later referred to as "Robles disease", was common among coffee plantation workers. Manifestations included subcutaneous nodules, anterior eye lesions, and dermatitis. Robles sent specimens to Émile Brumpt, a French parasitologist, who named it O. caecutiens in 1919, indicating the parasite caused blindness (Latin "caecus" meaning blind).[69] The disease was also reported as being common in Mexico.[70] By the early 1920s, it was generally agreed that the filaria in Africa and Central America were morphologically indistinguishable and the same as that described by O'Neill 50 years earlier.[citation needed]

Robles hypothesized that the vector of the disease was the day-biting black fly, Simulium. Scottish physician Donald Blacklock of the Liverpool School of Tropical Medicine confirmed this mode of transmission in studies in Sierra Leone. Blacklock's experiments included the re-infection of Simulium flies exposed to portions of the skin of infected subjects on which nodules were present, which led to the elucidation of the life cycle of the Onchocerca parasite.[71] Blacklock and others could find no evidence of eye disease in Africa. Jean Hissette, a Belgian ophthalmologist, discovered in 1930 that the organism was the cause of a "river blindness" in the Belgian Congo.[72] Some of the patients reported seeing tangled threads or worms in their vision, which were microfilariae moving freely in the aqueous humor of the anterior chamber of the eye.[73] Blacklock and Strong had thought the African worm did not affect the eyes, but Hissette reported that 50% of patients with onchocerciasis near the Sankuru River in the Belgian Congo had eye disease and 20% were blind. Hisette Isolated the microfilariae from an enucleated eye and described the typical chorioretinal scarring, later called the "Hissette-Ridley fundus" after another ophthalmologist, Harold Ridley, who also made extensive observations on onchocerciasis patients in northwest Ghana, publishing his findings in 1945.[74] Ridley first postulated that the disease was brought by the slave trade. The international scientific community was initially skeptical of Hisette's findings, but they were confirmed by the Harvard African Expedition of 1934, led by Richard P. Strong, an American tropical medicine physician.[75]

Society and culture

Since 1987, ivermectin has been provided free of charge for use in humans by Merck through the Mectizan donation program (MDP). The MDP works together with ministries of health and nongovernmental development organisations, such as the World Health Organization, to provide free ivermectin to those who need it in endemic areas.[76] Due to the joint efforts of NGOs and WHO, onchocerciasis is no longer an obstacle in socio-economic development.[77]

In 2015 William C. Campbell and Satoshi Ōmura were co-awarded half of that year's Nobel Prize in Physiology or Medicine for the discovery of the avermectin family of compounds, the forerunner of ivermectin. The latter has come to decrease the occurrence of lymphatic filariasis and onchocerciasis.[78]

Uganda's government, working with the Carter Center river blindness program since 1996, switched strategies for the distribution of Mectizan. The male-dominated volunteer distribution system had failed to take advantage of traditional kinship structures and roles. In 2014, the program switched from village health teams to community distributors, primarily selecting women to assure that everyone in the circle of their family and friends received river blindness information and Mectizan.[79]

In 2021, Nigeria had the greatest prevalence of onchocerciasis infections globally and attributed the infection to 30.2% of blindness cases in the country. A study from western Nigeria found that residents believed that the parasitic effects of the disease were necessary to stimulate fertility and that the disease was thought to be carried by all residents.[80]

Research

Animal models for the disease are somewhat limited, as the parasite only lives in primates, but there are close parallels. Litomosoides sigmodontis , which will naturally infect cotton rats, has been found to fully develop in BALB/c mice. Onchocerca ochengi, the closest relative of O. volvulus, lives in intradermal cavities in cattle, and is also spread by black flies. Both systems are useful, but not exact, animal models.[81]

A study of 2501 people in Ghana showed the prevalence rate doubled between 2000 and 2005 despite treatment, suggesting the parasite is developing resistance to the drug.[47][82][83] A clinical trial of another anti-parasitic agent, moxidectin (manufactured by Wyeth), began on July 1, 2009 (NCT00790998).[84]

A Cochrane review compared outcomes of people treated with ivermectin alone versus doxycycline plus ivermectin. While there were no differences in most vision-related outcomes between the two treatments, there was low-quality evidence suggesting treatment with doxycycline plus ivermectin showed improvement in iridocyclitis and punctate keratitis, over those treated with ivermectin alone.[85]

In 2017, WHO set up the Onchocerciasis Technical Advisory Subgroup (OTS) to further research and establish areas that require drug administration. The OTS also identifies co-endemic areas with lymphatic filariasis to properly treat Onchocerciasis and lymphatic filariasis.[citation needed]

WHO prioritizes research to eliminate onchocerciasis. Research approaches include: improving outreach efforts to marginalized populations, expanding the mapping of endemic areas of onchocerciasis, improving and standardizing information on mass drug administration, develop diagnostic approaches, surveillance strategies, and therapeutic approaches.[citation needed]

See also

References

  1. ^ a b c d e f g h i j k "Onchocerciasis Fact sheet N°374". who.int. World Health Organization. March 2014. Archived from the original on 16 March 2014. Retrieved 20 March 2014.
  2. ^ a b c "Onchocerciasis (also known as River Blindness) Prevention & Control". CDC.gov. US: Centers for Disease Control and Prevention. May 21, 2013. Archived from the original on 19 April 2014. Retrieved 20 March 2014.
  3. ^ a b c Murray P (2013). Medical microbiology (7th ed.). Philadelphia: Elsevier Saunders. p. 792. ISBN 978-0-323-08692-9. Archived from the original on 2017-09-08.
  4. ^ a b c Brunette GW (2011). CDC Health Information for International Travel 2012: The Yellow Book. Oxford University Press. p. 258. ISBN 978-0-19-983036-7. Archived from the original on 2017-09-08.
  5. ^ Vos T, Allen C, Arora M, et al. (8 October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015". The Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282.
  6. ^ a b "Parasites: Onchocerciasis (also known as River Blindness)". CDC.gov. US: Centers for Disease Control and Prevention. 21 May 2013. Archived from the original on 26 February 2014. Retrieved 20 March 2014.
  7. ^ a b "Parasites – Onchocerciasis (also known as River Blindness) Epidemiology & Risk Factors". CDC.gov. US: Centers for Disease Control and Prevention. 21 May 2013. Archived from the original on 19 April 2014. Retrieved 20 March 2014.
  8. ^ "Onchocerciasis (also known as River Blindness) Diagnosis". CDC.gov. US: Centers for Disease Control and Prevention. 21 May 2013. Archived from the original on 19 April 2014. Retrieved 20 March 2014.
  9. ^ Lok, James B., Walker, Edward D., Scoles, Glen A. (2004). "9. Filariasis". In Eldridge, Bruce F., Edman, John D., Edman, J. (eds.). Medical entomology (Revised ed.). Dordrecht: Kluwer Academic. p. 301. ISBN 978-1-4020-1794-0. Archived from the original on 2017-09-08.
  10. ^ a b "Onchocerciasis (river blindness)". who.int. World Health Organization. 11 January 2022. Retrieved 2022-02-06.
  11. ^ a b c d e f Burnham G (May 1998). "Onchocerciasis". The Lancet. 351 (9112): 1341–1346. doi:10.1016/S0140-6736(97)12450-3. PMID 9643811. S2CID 265737560.
  12. ^ Dalton M (2001). "Onchocerca volvulus". Animal Diversity Web. Retrieved 2023-11-18.
  13. ^ "Parasites - Onchocerciasis (also known as River Blindness)". Centers for Disease Control and Prevention. 2019-04-19.
  14. ^ "Life Cycle". Stanford University. Archived from the original on 2020-08-06. Retrieved 2018-10-06.
  15. ^ "Onchocerciasis FAQs". Center for Disease Control. CDC. 17 September 2020. Retrieved 18 November 2023.
  16. ^ "Onchocerciasis FAQs". Center for Disease Control. 17 September 2020. Retrieved 18 November 2023.
  17. ^ Burnham G (May 2, 1998). "Onchocerciasis" (PDF). The Lancet. 351 (9112): 1341–1346. doi:10.1016/S0140-6736(97)12450-3. PMID 9643811. S2CID 265737560. Retrieved 18 November 2023.
  18. ^ "Defeating River Blindness - USF Magazine Summer 2013". dev.magazine.usf.edu. Retrieved 2023-12-11.
  19. ^ "Onchocerciasis (River Blindness)". Cleveland Clinic. Retrieved 18 November 2023.
  20. ^ a b Garcia-Zalisnak DE, Sheppard Jr JD (22 June 2018). Roy Sr H (ed.). "Ophthalmologic Manifestations of Onchocerciasis Clinical Presentation". Medscape. Retrieved 8 December 2024.
  21. ^ Khoo P, Cabrera-Aguas M, Watson SL (2022). "Parasitic Eye Infections". In Rezaei N, Iovino F (eds.). Encyclopedia of Infection and Immunity. Vol. 3, Section 7. Elsevier. pp. 246–258. doi:10.1016/B978-0-12-818731-9.00120-8. ISBN 978-0-12-818731-9.
  22. ^ Babalola O (2011). "Ocular onchocerciasis: current management and future prospects". Clinical Ophthalmology. 5: 1479–1491. doi:10.2147/OPTH.S8372. PMC 3206119. PMID 22069350.
  23. ^ "Mazzotti Reaction | MicrobLog: Microbiology Training". Archived from the original on 2010-12-20. Retrieved 2011-01-25.
  24. ^ Dowell SF, Sejvar JJ, Riek L, Vandemaele KA, Lamunu M, Kuesel AC, Schmutzhard E, Matuja W, Bunga S, Foltz J, Nutman TB, Winkler AS, Mbonye AK (2013). "Nodding syndrome". Emerg Infect Dis. 19 (9): 1374–3. doi:10.3201/eid1909.130401. PMC 3810928. PMID 23965548.
  25. ^ a b c Klarmann-Schulz U (2017-09-12). "Treatment of lymphatic filariasis and onchocerciasis – current and new therapeutic approaches". doi:10.26226/morressier.5991c409d462b80292388d01. {{cite journal}}: Cite journal requires |journal= (help)
  26. ^ a b c d e f g h James, William D., Berger, Timothy G., Elston, Dirk M, Odom, Richard B. (2006). Andrews' Diseases of the Skin: clinical dermatology (10th ed.). Saunders Elsevier. ISBN 978-0-7216-2921-6. OCLC 62736861.
  27. ^ Marty AM. "Filariasis". eMedicine. Archived from the original on 2009-09-27. Retrieved 2009-10-22.
  28. ^ "Onchocerciasis (river blindness)". www.who.int. Retrieved 2023-11-16.
  29. ^ "WHO | Onchocerciasis Control Programme (OCP)". 2009-11-24. Archived from the original on 2009-11-24. Retrieved 2023-12-10.
  30. ^ Prevention CC (2019-09-09). "CDC - Onchocerciasis - Prevention & Control". www.cdc.gov. Retrieved 2023-12-10.
  31. ^ Amazigo U (September 2008). "The African Programme for Onchocerciasis Control (APOC)". Annals of Tropical Medicine and Parasitology. 102: 19–22. doi:10.1179/136485908X337436. ISSN 0003-4983. PMID 18718149. S2CID 25432708.
  32. ^ "WHO | African Programme for Onchocerciasis Control (APOC)". 2009-08-28. Archived from the original on 2009-08-28. Retrieved 2023-12-10.
  33. ^ Rebollo MP, Zoure H, Ogoussan K, Sodahlon Y, Ottesen EA, Cantey PT (March 2018). "Onchocerciasis: shifting the target from control to elimination requires a new first-step—elimination mapping". International Health. 10 (Suppl 1): i14 – i19. doi:10.1093/inthealth/ihx052. ISSN 1876-3413. PMC 5881272. PMID 29471341.
  34. ^ "WHO | Onchocerciasis Elimination Program for the Americas (OEPA)". 2011-04-16. Archived from the original on 2011-04-16. Retrieved 2023-12-10.
  35. ^ "News Scan for Jul 30, 2013 | CIDRAP". www.cidrap.umn.edu. 2013-07-30. Retrieved 2023-12-10.
  36. ^ "Onchocerciasis (river blindness)". www.who.int. Retrieved 2023-12-10.
  37. ^ Sauerbrey M (July 2013). "The Onchocerciasis Elimination Program for the Americas (OEPA)". Annals of Tropical Medicine & Parasitology. 102 (sup1): 25–29. doi:10.1179/136485908X337454. ISSN 0003-4983. PMID 18718151. S2CID 39612786.
  38. ^ Staff (2015-09-29). "Brazil and Venezuela border is the last place in the Americas with river blindness". Outbreak News Today. Retrieved 2023-12-10.
  39. ^ "Target product profiles". www.who.int. Retrieved 2023-12-10.
  40. ^ Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S (2015-01-29). "The Onchocerciasis Vaccine for Africa—TOVA—Initiative". PLOS Neglected Tropical Diseases. 9 (1): e0003422. doi:10.1371/journal.pntd.0003422. ISSN 1935-2727. PMC 4310604. PMID 25634641.
  41. ^ Borsboom GJ, Boatin BA, Nagelkerke NJ, Agoua H, Akpoboua KL, Alley EW, Bissan Y, Renz A, Yameogo L, Remme JH, Habbema JD (2003-03-24). "Impact of ivermectin on onchocerciasis transmission: assessing the empirical evidence that repeated ivermectin mass treatments may lead to elimination/eradication in West-Africa". Filaria Journal. 2 (1): 8. doi:10.1186/1475-2883-2-8. ISSN 1475-2883. PMC 156613. PMID 12769825.
  42. ^ Diawara L, Traoré MO, Badji A, Bissan Y, Doumbia K, Goita SF, Konaté L, Mounkoro K, Sarr MD, Seck AF, Toé L, Tourée S, Remme JH (2009-07-21). "Feasibility of Onchocerciasis Elimination with Ivermectin Treatment in Endemic Foci in Africa: First Evidence from Studies in Mali and Senegal". PLOS Neglected Tropical Diseases. 3 (7): e497. doi:10.1371/journal.pntd.0000497. ISSN 1935-2735. PMC 2710500. PMID 19621091. S2CID 2049325.
  43. ^ a b c d e Rea PA, Zhang V, Baras YS (2010). "Ivermectin and River Blindness". American Scientist. 98 (4): 294–303. Archived from the original on 2010-07-05. Retrieved 2010-06-20.
  44. ^ "CDC - Onchocerciasis - Treatment". Archived from the original on 2017-05-24. Retrieved 2017-05-15.
  45. ^ Trattler, Bill, Gladwin, Mark (2007). Clinical Microbiology Made Ridiculously Simple. Miami: MedMaster. ISBN 978-0-940780-81-1. OCLC 156907378.
  46. ^ Taylor MJ, Bandi C, Hoerauf A (2005). Wolbachia. Bacterial endosymbionts of filarial nematodes. Advances in Parasitology Vol. 60. Vol. 60. Academic Press. pp. 245–84. doi:10.1016/S0065-308X(05)60004-8. ISBN 978-0-12-031760-8. PMID 16230105. {{cite book}}: |journal= ignored (help)
  47. ^ a b Hoerauf A (2008). "Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis". Current Opinion in Infectious Diseases. 21 (6): 673–81. doi:10.1097/QCO.0b013e328315cde7. PMID 18978537. S2CID 26046513.
  48. ^ Yates DM, Wolstenholme AJ (August 2004). "An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis". International Journal for Parasitology. 34 (9): 1075–81. doi:10.1016/j.ijpara.2004.04.010. PMID 15313134.
  49. ^ Harder A (2002). "Chemotherapeutic approaches to nematodes: current knowledge and outlook". Parasitology Research. 88 (3): 272–7. doi:10.1007/s00436-001-0535-x. PMID 11954915. S2CID 41860363.
  50. ^ Wolstenholme AJ, Rogers AT (2005). "Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics". Parasitology. 131 (Suppl:S85–95): S85–95. doi:10.1017/S0031182005008218 (inactive 1 November 2024). PMID 16569295. S2CID 14474894.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  51. ^ Ejere HO, Schwartz E, Wormald R, Evans JR (2012). "Ivermectin for onchocercal eye disease (river blindness)". Cochrane Database Syst Rev. 8 (8): CD002219. doi:10.1002/14651858.CD002219.pub2. PMC 4425412. PMID 22895928.
  52. ^ "Progress on moxidectin for onchocerciasis elimination". tdr.who.int. Retrieved 2022-12-13.
  53. ^ "Moxidectin (Oral Route) Proper Use - Mayo Clinic". www.mayoclinic.org. Retrieved 2022-12-13.
  54. ^ Milton P, Hamley JI, Walker M, Basáñez MG (2020-11-01). "Moxidectin: an oral treatment for human onchocerciasis". Expert Review of Anti-infective Therapy. 18 (11): 1067–1081. doi:10.1080/14787210.2020.1792772. hdl:10044/1/81294. ISSN 1478-7210. PMID 32715787. S2CID 220798707.
  55. ^ a b "Onchocerciasis (river blindness)". www.who.int. Retrieved 15 March 2020.
  56. ^ a b "Epidemiology". Stanford University. 2006. Archived from the original on 2007-09-22.
  57. ^ Peña Flores G., Richards F., et al. (2010). "Lack of Onchocerca volvulus transmission in the northern focus in Chiapas". Am. J. Trop. Med. Hyg. 83 (1): 15–20. doi:10.4269/ajtmh.2010.09-0626. PMC 2912569. PMID 20595471.
  58. ^ Peña Flores G., Richards F., Domínguez A. (2010). "Interruption of transmission of Onchocerca volvulus in the Oaxaca focus". Am. J. Trop. Med. Hyg. 83 (1): 21–27. doi:10.4269/ajtmh.2010.09-0544. PMC 2912570. PMID 20595472.
  59. ^ "Onchocerciasis (river blindness)". www.who.int. Retrieved 2022-11-21.
  60. ^ Colebunders R, Nelson Siewe F, Hotterbeekx A (March 2018). "Onchocerciasis-Associated Epilepsy, an Additional Reason for Strengthening Onchocerciasis Elimination Programs". Trends in Parasitology. 34 (3): 208–216. doi:10.1016/j.pt.2017.11.009. PMID 29288080.
  61. ^ a b "Onchocerciasis (river blindness)". www.who.int. Retrieved 2022-12-13.
  62. ^ "CDC - Onchocerciasis - Epidemiology & Risk Factors". www.cdc.gov. 2019-09-09. Retrieved 2022-12-13.
  63. ^ a b Nyagang SM, Cumber SN, Cho JF, Keka EI, Nkfusai CN, Wepngong E, Tsoka-Gwegweni JM, Fokam EB (2020). "Prevalence of onchocerciasis, attitudes, and practices and the treatment coverage after 15 years of mass drug administration with ivermectin in the Tombel Health District, Cameroon". Pan African Medical Journal. 35: 107. doi:10.11604/pamj.2020.35.107.16036. PMC 7321683. PMID 32637005.
  64. ^ Nyagang SM, Cumber SN, Cho JF, Keka EI, Nkfusai CN, Wepngong E, Tsoka-Gwegweni JM, Fokam EB (2020-04-08). "Prevalence of onchocerciasis, attitudes and practices and the treatment coverage after 15 years of mass drug administration with ivermectin in the Tombel Health District, Cameroon". The Pan African Medical Journal. 35: 107. doi:10.11604/pamj.2020.35.107.16036. ISSN 1937-8688. PMC 7321683. PMID 32637005.
  65. ^ Zimmerman PA, Katholi CR, Wooten MC, Lang-Unnasch N, Unnasch TR (May 1994). "Recent evolutionary history of American Onchocerca volvulus, based on analysis of a tandemly repeated DNA sequence family". Molecular Biology and Evolution. 11 (3): 384–92. doi:10.1093/oxfordjournals.molbev.a040114. PMID 7516998.
  66. ^ O'Neill J (1875). "O'Neill J. On the presence of a filaria in craw-craw" (PDF). The Lancet. 105 (2686): 265–266. doi:10.1016/s0140-6736(02)30941-3. Archived (PDF) from the original on 2016-02-02.
  67. ^ "A Short History of Onchocerciasis". Archived from the original on 4 March 2016. Retrieved 18 October 2015.
  68. ^ Robles R (1917). "Enfermedad nueva en Guatemala". La Juventud Médica.
  69. ^ Strong R (1942). Stitt's Diagnosis, prevention and treatment of tropical diseases. The Blakiston.
  70. ^ Manson-Bahr PH (1943). Tropical diseases; a manual of the diseases of warm climates [Internet] (11th ed.). Williams & Wilkins Co.
  71. ^ Blacklock DB (22 January 1927). "The Insect Transmission of Onchocerca Volvulus (Leuckart, 1893): The Cause of Worm Nodules in Man in Africa". British Medical Journal. 1 (3446): 129–33. doi:10.1136/bmj.1.3446.129. PMC 2453973. PMID 20772951.
  72. ^ Kluxen G, Hoerauf A (2008). "The significance of some observations on African ocular onchocerciasis described by Jean Hissette (1888-1965)". Bull Soc Belge Ophtalmol. 307: 53–8.
  73. ^ Hisette J (1932). Mémoire sur l'Onchocerca volvulus Leuckart et ses manifestations oculaires au Congo belge. pp. 433–529.
  74. ^ Ridley H (1945). "OCULAR ONCHOCERCIASIS Including an Investigation in the Gold Coast". Br J Ophthalmol. 29 (Suppl): 3–58. doi:10.1136/bjo.29.suppl.3. PMC 513929. PMID 18170175.
  75. ^ Kluxen G. "Harvard African Expedition [Internet]". Archived from the original on 22 December 2015. Retrieved 18 October 2015.
  76. ^ Thylefors B, Alleman MM, Twum-Danso NA (May 2008). "Operational lessons from 20 years of the Mectizan Donation Program for the control of onchocerciasis". Trop Med Int Health. 13 (5): 689–96. doi:10.1111/j.1365-3156.2008.02049.x. PMID 18419585.
  77. ^ Organization WH (2002). "Onchocerciasis control in Niger: achievements and prospects after OCP". World Health Organization. hdl:10665/342987.
  78. ^ Jan Andersson, Hans Forssberg, Juleen R. Zierath (5 October 2015), Avermectin and Artemisinin - Revolutionary Therapies against Parasitic Diseases (PDF), The Nobel Assembly at Karolinska Institutet, archived (PDF) from the original on 5 October 2015, retrieved 5 October 2015
  79. ^ Kinship Powerful in River Blindness Fight. Carter Center Update, The Carter Center, Atlanta, Georgia. Summer, 2016. pp. 4-5.
  80. ^ Ajaegbu OO (March 2021). "Socio-cultural factors in onchocerciasis control: a study of rural Southeast Nigeria". Journal of Parasitic Diseases. 45 (1): 10–16. doi:10.1007/s12639-020-01269-7. ISSN 0971-7196. PMC 7921230. PMID 33746381.
  81. ^ Allen JE, Adjei O, Bain O, Hoerauf A, Hoffmann WH, Makepeace BL, Schulz-Key H, Tanya VN, Trees AJ, Wanji S, Taylor DW (April 2008). Lustigman S (ed.). "Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness". PLoS Negl Trop Dis. 2 (4): e217. doi:10.1371/journal.pntd.0000217. PMC 2323618. PMID 18446236.
  82. ^ "River blindness resistance fears". BBC News. 2007-06-14. Archived from the original on 2007-08-08. Retrieved 2007-06-15.
  83. ^ Osei-Atweneboana MY, Eng JK, Boakye DA, Gyapong JO, Prichard RK (June 2007). "Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study". Lancet. 369 (9578): 2021–9. doi:10.1016/S0140-6736(07)60942-8. PMID 17574093. S2CID 30650856.
  84. ^ Lancet T (2009-07-11). "Fighting river blindness and other ills". The Lancet. 374 (9684): 91. doi:10.1016/S0140-6736(09)61262-9. ISSN 0140-6736. PMID 19595328. S2CID 13401341.
  85. ^ Abegunde AT, Ahuja RM, Okafor NJ (2016). "Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis". Cochrane Database Syst Rev. 1 (1): CD011146. doi:10.1002/14651858.CD011146.pub2. PMC 5029467. PMID 26771164.
Look up onchocerciasis in Wiktionary, the free dictionary.

Read other articles:

Sejarah Gereja Katolik

Bagian dari seri tentangGereja KatolikBasilika Santo Petrus, Kota Vatikan Ikhtisar Paus (Fransiskus) Hierarki Sejarah (Lini Masa) Teologi Liturgi Sakramen Maria Latar Belakang Yesus Penyaliban Kebangkitan Kenaikan Gereja Perdana Petrus Paulus Bapa-Bapa Gereja Sejarah Gereja Katolik Sejarah Lembaga Kepausan Konsili Ekumene Magisterium Empat Ciri Gereja Satu Gereja Sejati Suksesi Apostolik Organisasi Takhta Suci Kuria Romawi Dewan Kardinal Konsili Ekumene Lembaga Keuskupan Gereja Latin Gereja-G...

 

7Q8

Naskah 7Q4, 7Q5, dan 7Q8. Diidentifikasi kemungkinan sebagai fragmen Perjanjian Baru. 7Q8 adalah suatu naskah kuno yang ditulis pada lembaran perkamen dalam bahasa Yunani yang ditemukan di gua 7 di Qumran, dan tergolong ke dalam kumpulan Naskah Laut Mati. Diperkirakan dibuat pada sekitar 100 tahun Sebelum Masehi. Teks naskah belum teridentifikasi pasti. Pada tahun 1972, José O'Callaghan mengidentifikasi fragmen ini berasal dari sekitar tahun 50 dan memuat salinan dari Surat Yakobus, yaitu Ya...

 

Langue agglutinante

Carte des langues agglutinantes en Europe En typologie morphologique, une langue agglutinante est une langue dont les traits grammaticaux sont marqués par l'assemblage d'éléments basiques appelés morphèmes, un morphème désignant ainsi le plus petit élément porteur d'un trait grammatical précis. Dans une langue agglutinante les mots sont formés par assemblage de ces morphèmes, qui sont hors exception invariables[1]. Les langues agglutinantes forment un sous-groupe des langues flexi...

Tadeusz Borowski

Polish writer and journalist Not to be confused with Tadeusz Bobrowski. Tadeusz BorowskiBorn(1922-11-12)12 November 1922Zhytomyr, Ukrainian SSR, Soviet UnionDied3 July 1951(1951-07-03) (aged 28)Warsaw, PolandOccupationwriter, journalistNationalityPolishGenrepoetry, short storiesNotable worksThis Way for the Gas, Ladies and GentlemenNotable awardsNational Literary Prize, Second Degree (Poland) Tadeusz Borowski (Polish pronunciation: [taˈdɛ.uʂ bɔˈrɔfskʲi]; 12 November 1922 �...

 

Mark Viduka

Australian soccer player (born 1975) Mark Viduka Viduka playing for Australia in 2005Personal informationFull name Mark Antony Viduka[1]Date of birth (1975-10-09) 9 October 1975 (age 48)Place of birth Melbourne, AustraliaHeight 1.88 m (6 ft 2 in)Position(s) ForwardYouth career1992–1993 AISSenior career*Years Team Apps (Gls)1993–1995 Melbourne Knights 48 (40)1995–1998 Dinamo Zagreb 84 (40)1998–2000 Celtic 37 (30)2000–2004 Leeds United 130 (59)2004–2007 M...

 

HAL (archive ouverte)

Pour les articles homonymes, voir HAL. HALHistoireFondation 2001CadreSigle HALType Archive ouverte, ressource continue, infrastructure de la science ouverte, bibliographic indexPays  FranceLangues Français, anglaisOrganisationFondateur Franck Laloë Marco Picco Daniel CharnayPropriétaire Centre pour la communication scientifique directeSite web hal.sciencemodifier - modifier le code - modifier Wikidata Ancien logo (2014–2021) HAL (HyperArticles en Ligne)[1] est une plateforme en lig...

Collins English Dictionary

This article may contain citations that do not verify the text. Please check for citation inaccuracies. (March 2023) (Learn how and when to remove this message) Printed and online dictionary of English, published by HarperCollins in Glasgow Collins English Dictionary Complete and Unabridged 13th edition The Collins English Dictionary is a printed and online dictionary of English. It is published by HarperCollins in Glasgow.[1] Corpus The dictionary uses language research based on the ...

 

ヨハネス12世 (ローマ教皇)

ヨハネス12世 第130代 ローマ教皇 教皇就任 955年12月16日教皇離任 964年5月14日先代 アガペトゥス2世次代 レオ8世個人情報出生 937年スポレート公国（中部イタリア）スポレート死去 964年5月14日 教皇領、ローマ原国籍 スポレート公国親 父アルベリーコ2世（スポレート公）、母アルダその他のヨハネステンプレートを表示 ヨハネス12世（Ioannes XII、937年 - 964年5月14日）は、ロ...

 

تشكيلات مخصوصة

المنظمة الخاصة في تركيا هي تنظيم سري تأسس داخل جمعية الاتحاد والترقي بناءاً على رغبة أنور باشا وكان يتضمن اَراء إسلاميين وأتراك جمعية الاتحاد والترقي داخل وخارج البلد ومكافحة التجسس والدعاية والتنظيم وحركات الاغتيال ووفقاً لتصريحات الشهود المختلفة فإن تأثيرها أصبح فعا�...

豪栄道豪太郎

豪栄道 豪太郎 場所入りする豪栄道基礎情報四股名 澤井 豪太郎→豪栄道 豪太郎本名 澤井 豪太郎愛称 ゴウタロウ、豪ちゃん、GAD[1][2]生年月日 (1986-04-06) 1986年4月6日（38歳）出身 大阪府寝屋川市身長 183cm体重 160kgBMI 47.26所属部屋 境川部屋得意技 右四つ・出し投げ・切り返し・外掛け・首投げ・右下手投げ成績現在の番付 引退最高位 東大関生涯戦歴 696勝493敗...

 

Realme 7

Smartphone by Chinese brand Realme 7 and Realme 7 ProBrandrealmeSloganEpic Power. Epic ChargeColorsMist Blue, Mist WhiteSeries7Compatible networks2G, 3G, 4G, 4G LTEPredecessorRealme 6SuccessorRealme 8Form factorSlateDimensions162.3 mm × 75.4 mm × 9.4 mm (6.39 in × 2.97 in × 0.37 in)Mass196.5 g (6.93 oz)Operating systemAndroidCPUMediatek Helio G95 Octa-core (2x2.05 GHz Cortex-A76 & 6x2.0 GHz Cortex-A55)BatteryLi-Po 5000 m...

 

Corruption in Bahrain

Institutional corruption in the country Political corruption Forms and concepts Bribery Cronyism Economics of corruption Electoral fraud Elite capture Influence peddling Kleptocracy Mafia state Nepotism Pyrrhic defeat theory Slush fund Simony State capture State-corporate crime Throffer Anti-corruption International Anti-Corruption Court Group of States Against Corruption International Anti-Corruption Academy International Anti-Corruption Day United Nations Convention against Corruption Corru...

Coscu

Argentine Twitch streamer (born 1991) In this Spanish name, the first or paternal surname is Pérez and the second or maternal family name is Disalvo. CoscuMartin in 2015Personal informationBornMartín Pérez Disalvo (1991-08-03) 3 August 1991 (age 32)[1]La Plata, Buenos Aires, ArgentinaOccupationTwitch streamerTwitch informationChannel coscu Years active2012–presentGenreGamingFollowers3.7 million[2]YouTube informationChannel Coscu Years active201...

 

Stadion Internasional Amman

Stadion Internasional Amman LokasiLokasiAmman, YordaniaKoordinat31°59′6.37″N 35°54′10.25″E / 31.9851028°N 35.9028472°E / 31.9851028; 35.9028472Data teknisPermukaanRumputKapasitas25.000Pemakai Tim nasional sepak bolaSunting kotak info • L • BBantuan penggunaan templat ini Stadion Internasional Amman (bahasa Arab: ستاد عمان الدولي) merupakan sebuah stadion yang terletak di Amman, Yordania. Stadion ini berkapasitas 25.000 orang,...

 

Territorial prelate

A Catholic prelate outside of a diocese This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Territorial prelate – news · newspapers · books · scholar · JSTOR (March 2017) (Learn how and when to remove this message) Part of a series on theHierarchy of theCatholic ChurchSaint Peter Ecclesiastical titles (order of ...

アメリカン・ロコモティブ

American Locomotive Company ALCOの製造銘板 (1945年)元の種類 民間企業業種 鉄道車両,発電機前身 リスト Brooks Locomotive Works Cooke Locomotive & Machine Works Dickson Manufacturing Company Manchester Locomotive Works Pittsburgh Locomotive and Car Works Rhode Island Locomotive Works Richmond Locomotive Works Schenectady Locomotive Works 設立 1901年 (123年前) (1901)解散 1969年 55年前 (1969)本社 ニューヨーク市、米国事業地�...

 

Chaplain of His Holiness

Ecclesiastical title in the Roman Catholic Church Generic coat of arms of a Chaplain of His Holiness Chaplain of His Holiness is a title of distinction given by the Pope in recognition of a priest’s service to the Church. They are addressed with the honorific of Monsignor and have certain privileges with respect to ecclesiastical dress and vestments. In 2013, Pope Francis amended common practice to require that all such priests be at least 65 years of age.[1] History The role of Cha...

 

Stradbroke

Barley Green redirects here. For the hamlet in Lancashire, see Barley, Lancashire. This article is about the village in Suffolk. For other uses, see Stradbroke (disambiguation). Stradbroke Village Sign Village in Mid-Suffolk, England Human settlement in EnglandStradbrokeChurch of All Saints, StradbrokeStradbrokeLocation within SuffolkArea15.35 km2 (5.93 sq mi)Population1,408 (2011)[1]• Density92/km2 (240/sq mi)OS grid referenceTM231739District...

De Cive

Book by Thomas Hobbes De Cive Frontispiece of De Cive, engraved by Jean Matheus. Between the state of nature and the civil life there is a large drape in the shape of amphora with the title of the work and a biblical quotation taken from Proverbs 8:15: Per me Reges regnant et legum conditores iusta decernunt; By me kings reign, and rulers decree what is just.[1][2]AuthorThomas HobbesCover artistJean MatheusLanguageLatin, EnglishPublication date1642, 1647Publication placeF...

 

Bartolomeo Cristofori

Italian maker of musical instruments Cristofori redirects here. For the surname, see Cristofori (surname). For other uses, see Cristofori (disambiguation). Bartolomeo CristoforiPhoto of a 1726 portrait of Bartolomeo Cristofori. The original was lost in the Second World War.BornBartolomeo Cristofori di Francesco(1655-05-04)May 4, 1655Padua, Republic of VeniceDiedJanuary 27, 1731(1731-01-27) (aged 75)Florence, Grand Duchy of TuscanyOccupation(s)Inventor, instrument makerKnown forInven...