PHTPP

PHTPP
Identifiers
  • 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H11F6N3O
Molar mass423.318 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F
  • InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
  • Key:AEZPAUSGTAHLOQ-UHFFFAOYSA-N

PHTPP is a synthetic, nonsteroidal, and highly selective antagonist of ERβ that is used in scientific research to study the function of this receptor.[1][2] It possesses 36-fold selectivity for ERβ over ERα, and is a silent antagonist of ERβ.[3]

See also

References

  1. ^ Neurosteroids. Frontiers E-books. pp. 95–. ISBN 978-2-88919-078-2.
  2. ^ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9.
  3. ^ Compton DR, Sheng S, Carlson KE, Rebacz NA, Lee IY, Katzenellenbogen BS, Katzenellenbogen JA (November 2004). "Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity". Journal of Medicinal Chemistry. 47 (24): 5872–93. doi:10.1021/jm049631k. PMID 15537344.
Stub icon

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Read other articles:

Acep Purnama

Acep Purnama Bupati Kuningan ke-24Masa jabatan14 Juni 2016 – 4 Desember 2023PresidenJoko WidodoGubernurAhmad HeryawanIwa Karniwa (Plh.)Mochamad Iriawan (Pj.)Ridwan KamilBey Machmudin (Pj.)WakilDede Sembada (2016–2018)M. Ridho Suganda (2018–2023) PendahuluUtje Hamid SugandaPenggantiRaden Iip Hidajat (Pj.)Wakil Bupati Kuningan ke-3Masa jabatan4 Desember 2013 – 7 April 2016PresidenSusilo Bambang YudhoyonoJoko WidodoGubernurAhmad Heryawan PendahuluMomon RochmanaP...

 

Gedung kantor pusat HSBC Hong Kong

HSBC Main Building香港上海滙豐銀行總行大廈Gedung Utama HSBC, Juni 2008Location within Hong KongInformasi umumStatusSelesaiJenisKantor komersialGaya arsitekturStructural ExpressionismLokasi1 Queen's Road, Sentral, Hong KongMulai dibangun1983Rampung1985BiayaUS$780 jutaTinggiAtap1.788 m (5.866,1 ft)Data teknisJumlah lantai44Luas lantai99.000 m2 (1.065.627 sq ft)Lift28Desain dan konstruksiArsitekFoster and PartnersTeknisi strukturOve Arup & PartnersClevela...

 

Daftar perguruan tinggi swasta di Jakarta

Berikut adalah Daftar perguruan tinggi swasta di Jakarta, yang pembinaannya berada di bawah Kementerian Pendidikan dan Kebudayaan Republik Indonesia dan Perguruan Tinggi Swasta Keagamaan, yang pembinaannya berada di bawah Kementerian Agama. Daftar ini tidak termasuk Perguruan Tinggi Kedinasan yang pembinaannya berada dibawah masing-masing kementerian/lembaga. Universitas Universitas 17 Agustus 1945 Jakarta (UTA45), Jakarta Utara Universitas Agung Podomoro, Jakarta Barat Universitas Al Azhar I...

Orsolina della Penna

Orsolina della Penna (Perugia, 1500 – 1536?) è stata una nobildonna italiana ed amante dell'imperatore Carlo V. Stemma della Penna Indice 1 Biografia 2 Note 3 Bibliografia 4 Collegamenti esterni Biografia Orsolina della Penna, conosciuta come la bella di Perugia ,[1] fu una nobile ed amante[2] segreta dell'imperatore Carlo V, conosciuto durante un viaggio nelle Fiandre del marito Valentino de’ Cancellieri alla corte di Bruxelles. Qui il marito si ammalò e morì. Orsolina...

 

Move Ya Hips

2020 single by ASAP Ferg featuring Nicki Minaj and MadeinTYO Move Ya HipsSingle by ASAP Ferg featuring Nicki Minaj and MadeinTYOfrom the album Floor Seats II ReleasedJuly 30, 2020 (2020-07-30)GenreHip hopLength2:26Label RCA A$AP Worldwide Polo Grounds Songwriter(s) Darold Brown Onika Maraj Malcolm Davis Frank Parra Producer(s)Frankie PASAP Ferg singles chronology Square Bitch (2020) Move Ya Hips (2020) No Ceilings (2020) Nicki Minaj singles chronology Trollz(2020) Move ...

 

Final Piala Raja Spanyol 1995

Final Piala Raja Spanyol 1995TurnamenPiala Raja Spanyol 1994–1995 Deportivo La Coruña Valencia 2 1 Tanggal24 Juni 1995Lanjutan: 27 Juni 1995StadionStadion Santiago Bernabéu, MadridWasitJosé María García-ArandaPenonton95.000Lanjutan: 81.000← 1994 1996 → Final Piala Raja Spanyol 1995 adalah pertandingan final ke-91 dari turnamen sepak bola Piala Raja Spanyol untuk menentukan juara musim 1994–1995. Pertandingan ini diikuti oleh Deportivo La Coruña dan Valencia dan diselengg...

Zapiekanka

Open-face sandwich made of half of a baguette or other long roll of bread ZapiekankaA typical zapiekanka served on a paper trayTypeStreet foodPlace of originPolandAssociated cuisinePolishInvented1970sServing temperatureHotMain ingredientsBaguette, button mushrooms, cheeseIngredients generally usedKetchup  Media: Zapiekanka A zapiekanka (Polish pronunciation: [zapʲɛˈkaŋka] ⓘ; plural: zapiekanki, pronounced [zapʲɛˈkaŋkʲi]) is a toasted open-face sandwich...

 

Jōshin Dentetsu Jōshin Line

Railway line in Gunma prefecture, Japan Joshin Dentetsu Joshin LineA Joshin Electric Railway 1000 series EMUOverviewOwnerJoshin Electric RailwayLocaleGunma PrefectureTerminiTakasakiShimonitaStations21HistoryOpened10 May 1897TechnicalLine length33.7 km (20.9 mi)Number of tracksSingleTrack gauge1,067 mm (3 ft 6 in)Minimum radius160 mElectrification1,500 V DC, overhead catenaryOperating speed85 km/h (55 mph)[1] The Joshin Line (上信線, Jōshin-s...

 

Anjanvel Fort

Fort in India Gopalgad Fortअंजनवेल चा किल्ला/ गोपाळगडPart of Malabar sea coastRatnagiri district, Maharashtra Anjanvel FortGopalgad FortCoordinates17°34′17.3″N 73°09′06.5″E / 17.571472°N 73.151806°E / 17.571472; 73.151806TypeSea fortHeight300 Ft.Site informationOwner India Government of IndiaControlled by Bijapur (–1660) Maratha (1660–1699)Janjira State (1699–1745) Maratha (1745–18...

Crédit agricole

Pour les articles homonymes, voir Crédit agricole (homonymie). Crédit agricole Création 1885 Dates clés 1920 : création de l'Office national de Crédit agricole, 1945 : création de la Fédération nationale de Crédit agricole,1991 : le Crédit agricole devient une banque universelle, 2001 : introduction en Bourse de Crédit agricole SA,2003 : rapprochement avec le Crédit lyonnais Forme juridique Société de groupe d’assurance mutuelle et société anonyme ...

 

M. K. Sanu

Indian writer (born 1928) M. K. SanuBorn (1926-10-27) 27 October 1926 (age 97)[1]Thumpoly, Kingdom of Travancore, British India(present day Alappuzha, Kerala, India)OccupationWriterCriticPoetBiographerJournalistLanguageMalayalamNationalityIndianGenrePoetry, essay, biographyWebsitewww.sanumash.com M. K. Sanu (born 27 October 1926) is an Indian Malayalam-language writer, critic, retired professor, biographer, journalist, orator, social activist, and human rights activist. He has au...

 

العلاقات الأرجنتينية النيكاراغوية

العلاقات الأرجنتينية النيكاراغوية الأرجنتين نيكاراغوا   الأرجنتين   نيكاراغوا تعديل مصدري - تعديل   العلاقات الأرجنتينية النيكاراغوية هي العلاقات الثنائية التي تجمع بين الأرجنتين ونيكاراغوا.[1][2][3][4][5] مقارنة بين البلدين هذه مقارنة عامة ...

TPG Telecom

Australian Telecommunications Company Not to be confused with TPG (ISP) or Vodafone Australia. TPG Telecom LimitedCompany typePublic companyTraded asASX: TPGIndustryTelecommunicationsPredecessorsAAPTHutchison TelecommunicationsSP TelecomTotal Peripherals GroupVodafone Hutchinson AustraliaVodafone AustraliaFounded2009HeadquartersNorth Sydney, New South Wales, AustraliaKey peopleIñaki Berroeta (CEO)Canning Fok (Chairman)ProductsPrepaid and postpaid mobile phones, fixed-line and wireless b...

 

乔冠华

乔冠华 中华人民共和国外交部部长 中国人民对外友好协会顾问 任期1974年11月—1976年12月总理周恩来 → 华国锋前任姬鹏飞继任黄华 个人资料性别男出生(1913-03-28)1913年3月28日 中華民國江蘇省盐城县逝世1983年9月22日(1983歲—09—22)（70歲） 中华人民共和国北京市籍贯江蘇鹽城国籍 中华人民共和国政党 中国共产党配偶明仁（1940年病逝） 龚澎（1970年病逝） 章含�...

 

1820 in the United States

List of events ← 1819 1818 1817 1820 in the United States → 1821 1822 1823 Decades: 1800s 1810s 1820s 1830s 1840s See also: History of the United States (1789–1849) Timeline of United States history (1820–1859) List of years in the United States 1820 in the United States1820 in U.S. states States Alabama Connecticut Delaware Georgia Illinois Indiana Kentucky Louisiana Maine Maryland Massachusetts Mississippi New Hampshire New Jersey New York North Carolina Ohio Pennsylvania Rh...

National Register of Historic Places listings in Warren County, New York

Location of Warren County in New York Map all coordinates using OpenStreetMap Download coordinates as: KML GPX (all coordinates) GPX (primary coordinates) GPX (secondary coordinates) List of Registered Historic Places in Warren County, New York This is intended to be a complete list of properties and districts listed on the National Register of Historic Places in Warren County, New York. The locations of National Register properties and districts (at least for all showing latitude and longit...

 

Quassaick Creek

River in the United States of America Quassaick CreekQuassaic CreekCreek along the Newburgh city-town lineEtymologyAlgonquian for stony brook[1]LocationCountryUnited StatesStateNew YorkCountiesOrange, UlsterMunicipalityTown of Plattekill,Town of Newburgh,City of Newburgh,Town of New WindsorPhysical characteristicsSourceE of Tuckers Corner • coordinates41°39′45″N 74°01′34″W / 41.66250°N 74.02611°W / 41.66250; -74.02611 ̶...

 

جائزة إسبانيا الكبرى 1997

جائزة إسبانيا الكبرى 1997 السباق 6 من أصل 17 في بطولة العالم لسباقات الفورمولا واحد موسم 1997 السلسلة بطولة العالم لسباقات فورمولا 1 موسم 1997  البلد إسبانيا  التاريخ 25 مايو 1997 مكان التنظيم حلبة دي كاتلونيا، برشلونة، إسبانيا طول المسار 4.728 كيلومتر (2.938 ميل) المسافة 302.469 كيلو...

مقدمة في ميكانيكا الكم

هذا المقال هو مقدمة غير تقانية للوصول لهذا الموضوع، ولقراءة المقال الرئيسي راجع ميكانيكا الكم. جزء من سلسلة مقالات حولميكانيكا الكم i ℏ ∂ ∂ t | ψ ( t ) ⟩ = H ^ | ψ ( t ) ⟩ {\displaystyle i\hbar {\frac {\partial }{\partial t}}|\psi (t)\rangle ={\hat {H}}|\psi (t)\rangle } معادلة شرودنغر مقدمة معجم تاريخ ...

 

Ливрея

Экспонаты Метрополитен-музея. Начало XIX века Камердинер рейхспрезидента Гинденбурга в гала-ливрее по случаю новогоднего приёма для зарубежных дипломатов. 1931 Ливре́я (фр. livrée — отправленная, порученная) — в буржуазных домах и при дворах форменная одежда особого ...