Cyclodiol

Cyclodiol
Clinical data
Other namesZK-115194; Cycloestradiol; 14α,17α-Ethano-17β-estradiol; 14α,17α-Ethanoestra-1,3,5(10)-triene-3,17β-diol; 14,21-Cyclo-19-norpregna-1,3,5(10)-triene-3,17α-diol
Routes of
administration		By mouth[1]
Drug classEstrogen
Pharmacokinetic data
Bioavailability33 ± 19%[1]
Elimination half-life28.7 hours[1]
Identifiers
  • (8R,9S,13S)-13-Methyl-7,8,9,11,12,13,15,16-octahydro-14,17-ethanocyclopenta[a]phenanthrene-3,17(6H)-diol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H26O2
Molar mass298.426 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@H](C14CCC2(CC4)O)CCC5=C3C=CC(=C5)O
  • InChI=1S/C20H26O2/c1-18-7-6-16-15-4-3-14(21)12-13(15)2-5-17(16)19(18)8-10-20(18,22)11-9-19/h3-4,12,16-17,21-22H,2,5-11H2,1H3/t16-,17-,18+,19?,20?/m1/s1
  • Key:YGXXZMDWSWSCSI-UYUJGIFYSA-N

Cyclodiol (developmental code name ZK-115194; also known as 14α,17α-ethano-17β-estradiol) is a synthetic estrogen which was studied in the 1990s and was never marketed.[2][1][3] It is a derivative of estradiol with a bridge between the C14α and C17α positions.[2][1][3][4] Cyclodiol has 100% of the relative binding affinity of estradiol for the human ERα and similar transactivational capacity as estradiol at the receptor.[2] It has comparable potency to estradiol when administered by subcutaneous injection.[2] The drug shows genotoxicity similarly to estradiol.[2][4] Cyclodiol showed an absolute bioavailability of 33 ± 19% and an elimination half-life of 28.7 hours in pharmacokinetic studies in women.[1]

See also

References

  1. ^ a b c d e f Baumann A, Fuhrmeister A, Brudny-Klöppel M, Draeger C, Bunte T, Kuhnz W (October 1996). "Comparative pharmacokinetics of two new steroidal estrogens and ethinylestradiol in postmenopausal women". Contraception. 54 (4): 235–242. doi:10.1016/S0010-7824(96)00194-1. PMID 8922877.
  2. ^ a b c d e Oettel M, Schillinger E (6 December 2012). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. pp. 10, 15, 76, 329, 332. ISBN 978-3-642-60107-1.
  3. ^ a b Lang R, Reimann R (1993). "Studies for a genotoxic potential of some endogenous and exogenous sex steroids. I. Communication: examination for the induction of gene mutations using the Ames Salmonella/microsome test and the HGPRT test in V79 cells". Environmental and Molecular Mutagenesis. 21 (3): 272–304. doi:10.1002/em.2850210311. PMID 8462531. S2CID 39049586.
  4. ^ a b Hundal BS, Dhillon VS, Sidhu IS (March 1997). "Genotoxic potential of estrogens". Mutation Research. 389 (2–3): 173–181. doi:10.1016/S1383-5718(96)00144-1. PMID 9093381.
Stub icon

This article about a steroid is a stub. You can help Wikipedia by expanding it.

Stub icon

This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.

Read other articles:

Opération Compass

Opération Compass Carte de la région de l'opération Compass. Informations générales Date 9 décembre 1940 – 9 février 1941 Lieu Cyrénaïque, Libye italienne Issue Victoire alliée décisive Belligérants Empire britannique Royaume-Uni Raj britannique Australie Rhodésie du Sud  France libre Royaume d'Italie Libye italienne Commandants Archibald Wavell Henry Maitland Wilson Richard O'Connor Iven Mackay Rodolfo Graziani Giuseppe Tellera † Pietro Maletti † Annibale Ber...

 

Lipizzan

Seekor Lipizzan modern Lipizzan atau Lipizzaner (Kroasia: Lipicanaccode: hr is deprecated , Ceska: Lipicáncode: cs is deprecated , Hongaria: Lipicaicode: hu is deprecated , Italia: Lipizzanocode: it is deprecated , bahasa Slovenia: Lipicanec), adalah sebuah jenis kuda yang saat berkaitan dengan Aliran Menunggang Spanyol dari Wina, Austria, dimana mereka mendemonstrasikan haute école atau gerakan aliran tinggi dari cara menunggang klasik, yang meliputi lompatan khas yang sangat terkontro...

 

Rage (video game)

2011 video game For the game engine, see Rockstar Advanced Game Engine. 2011 video gameRageDeveloper(s)id Software[a]Publisher(s)Bethesda SoftworksDirector(s)Tim WillitsProducer(s)Hunter HynemanJason KimMatthew NelsonProgrammer(s)Robert DuffyJan Paul van WaverenWriter(s)Matthew J. CostelloComposer(s)Rod AbernethyEngineid Tech 5Platform(s)Microsoft WindowsPlayStation 3Xbox 360OS XReleaseWindows, PlayStation 3, Xbox 360NA: October 4, 2011AU: October 6, 2011EU: October 7, 2011OS XWW: Feb...

The Passion: New Orleans

For other uses, see The Passion (disambiguation). American TV series or program The Passion: New OrleansCreated byJacco DoornbosBased onThe Passion franchiseWritten byPeter BarsocchiniDirected byDavid GrifhorstPresented byTyler PerryStarring Jencarlos Trisha Yearwood Prince Royce Chris Daughtry Seal ComposerAdam Anders Peer AstromCountry of originUnited StatesOriginal languageEnglishProductionExecutive producerRobert DeatonProducers Allen Shapiro Adam Anders Mike Mahan Mark Bracco David Arves...

 

Mansoor Khan

Halaman ini berisi artikel tentang sutradara India. Untuk pemain sepak bola Pakistan, lihat Mansoor Khan (pemain sepak bola). Mansoor KhanSutradara Mansoor Khan Hari Jadi ke-25 'Qayamat Se Qayamat Tak' 2013LahirHyderabad, IndiaPekerjaanProduser Film, Sutradara dan mansoorAyesha Hussain Mansoor Khan adalah seorang sutradara dan produser film India yang dikenal atas karya-karyanya dalam Bollywood. Putra dari pembuat film Nasir Hussain, Khan membuat debut penyutradaraannya dengan super-hit Qayam...

 

Anjing pelacak

Pelatihan anjing pelacak di angkatan laut Amerika Serikat untuk mendeteksi narkoba. Anjing pelacak atau anjing pengendus adalah anjing yang telah dilatih untuk menggunakan indranya (hampir selalu menggunakan indra penciuman) untuk mendeteksi substansi seperti bahan peledak, obat-obatan terlarang, selundupan hewan atau tumbuhan, uang, atau darah. Anjing berburu yang mencari buruan dan anjing pencari yang mencari orang yang hilang biasanya dianggap berbeda dengan anjing pelacak. Namun, terdapat...

Zoutpansberg

Zoutpansberg di peta tahun 1897. Zoutpansberg adalah divisi timur laut di Republik Transvaal, Afrika Selatan. Para pelopor Die Groot Trek, Louis Tregardt dan Lang Hans van Rensburg, berkelana di kawasan ini pada tahun 1835. Pada tahun 1845, Hendrik Potgieter yang merupakan salah satu pemimpin kelompok Voortrekker pindah ke kawasan ini. Kelompok Boer di Zoutpansberg kemudian membentuk komunitas semi-independen. Pada tahun 1857, komandan-jenderal Zoutpansberg yang bernama Stephanus Schoeman mem...

 

Hemsworth

Town and civil parish in West Yorkshire, England For other uses, see Hemsworth (disambiguation). Human settlement in EnglandHemsworthArchbishop Holgate AlmshouseHemsworthLocation within West YorkshirePopulation13,533 (2011 Census)[1]OS grid referenceSE430128Civil parishHemsworthMetropolitan boroughCity of WakefieldMetropolitan countyWest YorkshireRegionYorkshire and the HumberCountryEnglandSovereign stateUnited KingdomPost townPONTEFRACTPostcode dist...

 

Peppered moth

Species of moth This article is about the insect. For the Margaret Drabble novel, see The Peppered Moth. Peppered moth Male Female Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Arthropoda Class: Insecta Order: Lepidoptera Family: Geometridae Genus: Biston Species: B. betularia Binomial name Biston betulariaLinnaeus, 1758 Subspecies B. b. alexandrina (Wehrli, 1941) B. b. betularia B. b. cognataria (Guenée, 1857) B. b. contrasta (Barnes & Benjamin, 1923) B. b. ...

Musée du jouet de Colmar

Pour les articles homonymes, voir Musée du jouet. Musée du jouet de ColmarInformations généralesType Musée du jouetOuverture 1993Surface 400 m2Visiteurs par an 72 289 (2016)Site web www.museejouet.comLocalisationPays FranceDivision administrative Haut-RhinCommune ColmarAdresse 40 rue Vauban 68000 ColmarCoordonnées 48° 04′ 46″ N, 7° 21′ 44″ Emodifier - modifier le code - modifier Wikidata Le musée du jouet est un musée consacré aux jo...

 

British Basketball League 2007-2008

A questa voce o sezione va aggiunto il template sinottico {{Competizione cestistica nazionale}} Puoi aggiungere e riempire il template secondo le istruzioni e poi rimuovere questo avviso. Se non sei in grado di riempirlo in buona parte, non fare nulla; non inserire template vuoti. Classifica Squadra Partite Vinte Perse In casa Fuori casa Punti 1. Newcastle Eagles 33 29 4 16-1 13-3 58 2. Guildford Heat 33 24 9 11-5 13-4 48 3. Plymouth Raiders 33 24 9 14-2 10...

 

Athletics at the 1962 British Empire and Commonwealth Games – Men's 3 miles

Men's 3 miles at the 1962 British Empire and Commonwealth GamesVenuePerry Lakes StadiumDate26 November 1962 (1962-11-26)Competitors18 from 9 nationsWinning time13:34.2Medalists  Murray Halberg   New Zealand Ron Clarke   Australia Bruce Kidd   Canada← 19581966 → Athletics at the 1962 British Empireand Commonwealth GamesTrack events100 ydmenwomen220 ydmenwomen440 ydmen880 ydmenwomen1 mile...

2005 Florida Gators football team

American college football season 2005 Florida Gators footballOutback Bowl championOutback Bowl, W 31–24 vs. IowaConferenceSoutheastern ConferenceDivisionEastern DivisionRankingCoachesNo. 16APNo. 12Record9–3 (5–3 SEC)Head coachUrban Meyer (1st season)Offensive coordinatorDan Mullen (1st season)Offensive schemeSpread optionCo-defensive coordinatorCharlie Strong (3rd season)Co-defensive coordinatorGreg Mattison (1st season)Base defense4–3CaptainVer...

 

哈萨克斯坦总统

此条目序言章节没有充分总结全文内容要点。 (2019年3月21日)请考虑扩充序言，清晰概述条目所有重點。请在条目的讨论页讨论此问题。 哈萨克斯坦總統哈薩克總統旗現任Қасым-Жомарт Кемелұлы Тоқаев卡瑟姆若马尔特·托卡耶夫自2019年3月20日在任任期7年首任努尔苏丹·纳扎尔巴耶夫设立1990年4月24日（哈薩克蘇維埃社會主義共和國總統） 哈萨克斯坦 哈萨克斯坦政府...

 

ممدوح فرج

ممدوح فرج معلومات شخصية اسم الولادة ممدوح محمد فرج  الميلاد 16 أغسطس 1951   الإسكندرية  الوفاة 16 أغسطس 2014 (63 سنة)   المهندسين  سبب الوفاة نزف مخي  الجنسية المملكة المصرية (1951–1953) جمهورية مصر (1953–1958) الجمهورية العربية المتحدة (1958–1971) مصر (1971–2014) النمسا (1979–1996)  �...

Dream of the Rarebit Fiend

Dream of the Rarebit FiendEpisode Rarebit Fiend 28 Januari 1905PengarangWinsor McCayMulai10 September 1904 (1904-09-10)Selesaic. 1925Judul alternatif The Dream of a Lobster Fiend Midsummer Day Dreams It Was Only a Dream Rarebit Reveries PenerbitanNew York HeraldDidahului olehLittle Sammy SneezeDilanjutkan olehLittle Nemo Dream of the Rarebit Fiend adalah sebuah strip komik surat kabar karya kartunis Amerika Winsor McCay, yang dimulai pada 10 September 1904. Karua tersebut adalah st...

 

Tsu-Jae King Liu

American electrical engineer Tsu-Jae King LiuDean of the UC Berkeley College of EngineeringIncumbentAssumed office June 2018 Personal detailsBorn (1963-06-04) June 4, 1963 (age 61)Ithaca, New York, U.S.Alma materStanford University (BS, MS, PhD) Tsu-Jae King Liu is an American academic and engineer who serves as the Dean and the Roy W. Carlson Professor of Engineering at the UC Berkeley College of Engineering. Liu is an electrical engineer with extensive expertise and achievements in...

 

Concrete Plant Park

Public park in the Bronx, New York Concrete Plant ParkConcrete Plant Park, looking southTypePublic parkLocationThe Bronx, New York CityCoordinates40°49′31″N 73°53′06″W / 40.825201°N 73.885117°W / 40.825201; -73.885117Area7.39 acres (2.99 ha)Created2009Operated byNew York City Department of Parks and RecreationStatusOpen all yearWaterBronx RiverPublic transit accessNew York City Subway: Whitlock Avenue (), Simpson Street (​)New York City Bus:...

Mobile Servicing System

Mobile Servicing System (MSS), lebih dikenal dengan komponen utamanya Canadarm2, adalah sistem robot dan peralatan yang terkait di Stasiun Luar Angkasa Internasional (ISS). Diluncurkan ke ISS pada tahun 2001, alat ini memainkan peran kunci dalam perakitan stasiun dan pemeliharaan; peralatan dan perlengkapan bergerak di sekitar stasiun, mendukung astronaut bekerja di ruang angkasa, dan instrumen jasa dan muatan lain yang melekat pada ISS. Astronaut menerima pelatihan khusus untuk memungkinkan...

 

Aviron aux Jeux olympiques

Aviron aux Jeux olympiques Généralités Sport Aviron Création 1896 1re apparition Paris, 1900 Organisateur(s) CIO Éditions 29 (en 2024) Périodicité Tous les 4 ans Épreuves 14 (en 2024) Pour la compétition à venir voir : Aviron aux Jeux olympiques d'été de 2024 modifier L'aviron figure au programme des Jeux olympiques depuis 1900, les épreuves de 1896 étant annulées pour cause d'intempéries. Jusqu'en 1976, seuls les rameurs masculins étaient autorisés à participer ...