The Murrindal River rises below Butchers Ridge, and flows generally south, joined by one minor tributary, before reaching its confluence with the Buchan River west of Lucas Point in the Shire of East Gippsland. The river descends 647 metres (2,123 ft) over its 42-kilometre (26 mi) course.[2]
At the locality of Murrindal, the river is traversed by the Gelantipy Road.[2]