Formed by the confluence of the Humffray River West Branch and Humffray River East Branch, the Humffray River rises below the Tea Tree Range within the Great Dividing Range, northeast of the Wonnangatta River Reference Area and flows generally south by east, joined by one minor tributary before reaching its confluence with the Wonnangatta River in remote country below Little Baldy within the Alpine National Park in the Alpine Shire. The river descends 133 metres (436 ft) over its 14-kilometre (8.7 mi) course.[2]