The Deddick River rises below Mount Little Bill in a remote alpine wilderness area within the Snowy River National Park, and flows generally north leaving the national park, then northwest through the locality of Tubbut, and then west southwest. The river is joined by the Bonang River and sixteen minor tributaries, before reaching its confluence with the Snowy River in the Snowy River National Park below Mount Bulla Bulla, a few hundred metres north of the McKillops Bridge in the Shire of East Gippsland. The river descends 693 metres (2,274 ft) over its 60-kilometre (37 mi) course.[2]
McKillops Road is located adjacent to much of the course of the river, and traverses the river on several occasions.[2][3]