The Caledonia River rises below Minogues Lookout within the Snowy Range of the Great Dividing Range. The river flows generally south then south by west and then south, joined by the five tributaries including the Caledonia River East Branch (which is also joined by the Caledonia River Middle Branch), before reaching its confluence with the Macalister River, near The Sisters, in the Shire of Wellington. The river descends 743 metres (2,438 ft) over its 34-kilometre (21 mi) course.[2]