He was elected federal representative, mayor of São Paulo City (1983–1985), senator and twice Governor of the state of São Paulo. He was governor from 1994 to 1998, defeating Francisco Rossi in the run-off, and from 1998, defeating Paulo Maluf in the run-off, to his death in 2001. He was a founder and member of PMDB (Party of the Brazilian Democratic Movement) and later PSDB (Brazilian Social Democracy Party). In 1989, he was the PSDB presidential candidate, receiving 11% of the votes. In the run-off of that election, he supported, like his party, Luiz Inácio Lula da Silva.
He took a medical leave of absence on 22 January 2001, due to bladder cancer found during an operation to remove a prostate tumor.[1] He died later the same year. His successor was his deputy, Geraldo Alckmin.