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FGF13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HBW, 4DCK, 4JPZ
Identifiers
Aliases	FGF13, FGF-13, FGF2, FHF-2, FHF2, fibroblast growth factor 13
External IDs	OMIM: 300070; MGI: 109178; HomoloGene: 3036; GeneCards: FGF13; OMA:FGF13 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	139,222,777 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	58,613,431 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; spinal ganglia; ; Region I of hippocampus proper; ; pars reticulata; ; orbitofrontal cortex; ; trigeminal ganglion; ; middle temporal gyrus; ; Brodmann area 46; ; postcentral gyrus; ; superior frontal gyrus;
	Top expressed in
	ventral tegmental area; ; substantia nigra; ; subiculum; ; medial geniculate nucleus; ; medial dorsal nucleus; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex; ; anterior amygdaloid area; ; habenula; ; lateral geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activator activity; protein binding; growth factor activity; microtubule binding; sodium channel regulator activity; transmembrane transporter binding; beta-tubulin binding;
Cellular component	cell projection; filopodium; growth cone; extracellular region; dendrite; nucleolus; microtubule; nucleus; cytoplasm; cytosol; plasma membrane; intercalated disc; lateral plasma membrane; axon; neuron projection;
Biological process	cell-cell signaling; nervous system development; MAPK cascade; signal transduction; neuron migration; activation of protein kinase activity; establishment of neuroblast polarity; negative regulation of collateral sprouting; sodium ion transport; negative regulation of microtubule depolymerization; learning; memory; hippocampus development; cerebral cortex cell migration; microtubule polymerization; protein localization to plasma membrane; regulation of cardiac muscle cell action potential involved in regulation of contraction; response to odorant; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2258
	14168
	ENSG00000129682
	ENSMUSG00000031137
	Q92913
	P70377
NM_001139498; NM_001139500; NM_001139501; NM_001139502; NM_004114;
	NM_033642
	NM_001290414; NM_001290415; NM_010200; NM_001356335
NP_001132970; NP_001132972; NP_001132973; NP_001132974; NP_004105;
	NP_378668
	NP_001277343; NP_001277344; NP_034330; NP_001343264
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.^[5]^[6]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, invasion, and neuronal physiology. This gene is located to a region associated with Börjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked intellectual disability, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Several alternatively spliced transcripts encoding different isoforms have been described for this gene.^[6] FGF13 isoform 1 (FGF13A) binds to the leucine-rich repeats of the hominid-specific receptor LRRC37B.^[7] In human pyramidal neurons of the cerebral cortex, this interaction leads to a lower excitability,^[7] a divergent cellular property of human pyramidal neurons compared to other mammals.^[7]