Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12gene.[5][6][7]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]
^Liu Y, Chiu IM (Nov 1997). "Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization". Cytogenet Cell Genet. 78 (1): 48–9. doi:10.1159/000134625. PMID9345906.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID7829101.
Kok LD, Tsui SK, Waye M, et al. (1999). "Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart". Biochem. Biophys. Res. Commun. 255 (3): 717–21. doi:10.1006/bbrc.1999.0178. PMID10049777.
