Chondroitin 6-sulfotransferase

chondroitin 6-sulfotransferase
Identifiers
EC no.2.8.2.17
CAS no.83589-04-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a chondroitin 6-sulfotransferase (EC 2.8.2.17) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + chondroitin adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and Chondroitin 6-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase. Other names in common use include chondroitin 6-O-sulfotransferase, 3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate, sulfotransferase, and terminal 6-sulfotransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1.

References

  • Habuchi O, Miyashita N (1982). "Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage". Biochim. Biophys. Acta. 717 (3): 414–21. doi:10.1016/0304-4165(82)90282-3. PMID 6957247.


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